ID H9ULE2_SPIAZ Unreviewed; 252 AA.
AC H9ULE2;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Anaerobic ribonucleoside-triphosphate reductase activating protein {ECO:0000313|EMBL:AFG38335.1};
GN OrderedLocusNames=Spiaf_2302 {ECO:0000313|EMBL:AFG38335.1};
OS Spirochaeta africana (strain ATCC 700263 / DSM 8902 / Z-7692).
OC Bacteria; Spirochaetota; Spirochaetia; Spirochaetales; Spirochaetaceae;
OC Spirochaeta.
OX NCBI_TaxID=889378 {ECO:0000313|EMBL:AFG38335.1, ECO:0000313|Proteomes:UP000007383};
RN [1] {ECO:0000313|Proteomes:UP000007383}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ATCC 700263 / DSM 8902 / Z-7692
RC {ECO:0000313|Proteomes:UP000007383};
RX PubMed=23991249; DOI=10.4056/sigs.3607108;
RA Liolos K., Abt B., Scheuner C., Teshima H., Held B., Lapidus A., Nolan M.,
RA Lucas S., Deshpande S., Cheng J.F., Tapia R., Goodwin L.A., Pitluck S.,
RA Pagani I., Ivanova N., Mavromatis K., Mikhailova N., Huntemann M., Pati A.,
RA Chen A., Palaniappan K., Land M., Rohde M., Tindall B.J., Detter J.C.,
RA Goker M., Bristow J., Eisen J.A., Markowitz V., Hugenholtz P., Woyke T.,
RA Klenk H.P., Kyrpides N.C.;
RT "Complete genome sequence of the halophilic bacterium Spirochaeta africana
RT type strain (Z-7692(T)) from the alkaline Lake Magadi in the East African
RT Rift.";
RL Stand. Genomic Sci. 8:165-176(2013).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP003282; AFG38335.1; -; Genomic_DNA.
DR RefSeq; WP_014456317.1; NC_017098.1.
DR AlphaFoldDB; H9ULE2; -.
DR STRING; 889378.Spiaf_2302; -.
DR KEGG; sfc:Spiaf_2302; -.
DR PATRIC; fig|889378.3.peg.2274; -.
DR eggNOG; COG1180; Bacteria.
DR HOGENOM; CLU_078147_2_1_12; -.
DR OrthoDB; 9782387at2; -.
DR Proteomes; UP000007383; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR012840; NrdG2.
DR InterPro; IPR034457; Organic_radical-activating.
DR InterPro; IPR007197; rSAM.
DR NCBIfam; TIGR02495; NrdG2; 1.
DR PANTHER; PTHR30352; PYRUVATE FORMATE-LYASE-ACTIVATING ENZYME; 1.
DR Pfam; PF13353; Fer4_12; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SFLD; SFLDG01094; Uncharacterised_Radical_SAM_Su; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007383};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 22..243
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 252 AA; 27286 MW; 99B12B2A4FA377D9 CRC64;
MGRRGPEVSL KRLGLQATTL LDYPGKVAAM VFTMGCPLRC PYCHNPQLVH GSPPAGFLAR
EEVLRRLARR RHLLQGVVIT GGEPLRHHDI GGLLDDVHAL GLPVKLDTCG WYPAALAGVL
EHPGLQYVAM DIKTLPEHYG RVAAGRGLGG TVLSRSPAIR ESVAVLRNWR DAQPERGLEY
RTVCAPGVVD PGDLAGIARM LQPGDRWRLS QFQPGSCLDP TWNARTPFDT AVLEQAAAAA
CRRGVDAWTV GV
//
