ID H9YAG8_9CAUD Unreviewed; 166 AA.
AC H9YAG8;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 03-MAY-2023, entry version 32.
DE RecName: Full=Thymidine kinase {ECO:0000256|ARBA:ARBA00012118, ECO:0000256|RuleBase:RU000544};
DE EC=2.7.1.21 {ECO:0000256|ARBA:ARBA00012118, ECO:0000256|RuleBase:RU000544};
GN ORFNames=VP3_0020 {ECO:0000313|EMBL:AFH14420.1};
OS Vibrio phage VP3.
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Autographiviridae; Studiervirinae; Chatterjeevirus; Chatterjeevirus VP4.
OX NCBI_TaxID=588068 {ECO:0000313|EMBL:AFH14420.1, ECO:0000313|Proteomes:UP000007396};
RN [1] {ECO:0000313|EMBL:AFH14420.1, ECO:0000313|Proteomes:UP000007396}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23543142; DOI=10.1007/s00705-013-1676-9;
RA Li W., Zhang J., Chen Z., Zhang Q., Zhang L., Du P., Chen C., Kan B.;
RT "The genome of VP3, a T7-like phage used for the typing of Vibrio
RT cholerae.";
RL Arch. Virol. 158:1865-1876(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + thymidine = ADP + dTMP + H(+); Xref=Rhea:RHEA:19129,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17748, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:63528, ChEBI:CHEBI:456216; EC=2.7.1.21;
CC Evidence={ECO:0000256|RuleBase:RU000544};
CC -!- SIMILARITY: Belongs to the thymidine kinase family.
CC {ECO:0000256|ARBA:ARBA00007587, ECO:0000256|RuleBase:RU004165}.
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DR EMBL; JQ780163; AFH14420.1; -; Genomic_DNA.
DR Proteomes; UP000007396; Genome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001267; Thymidine_kinase.
DR PANTHER; PTHR11441; THYMIDINE KINASE; 1.
DR PANTHER; PTHR11441:SF0; THYMIDINE KINASE, CYTOSOLIC; 1.
DR Pfam; PF00265; TK; 1.
DR PIRSF; PIRSF035805; TK_cell; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU000544};
KW DNA synthesis {ECO:0000256|ARBA:ARBA00022634,
KW ECO:0000256|RuleBase:RU000544};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU000544};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU000544};
KW Reference proteome {ECO:0000313|Proteomes:UP000007396};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000544}.
FT ACT_SITE 76
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR035805-1"
SQ SEQUENCE 166 AA; 19118 MW; 879DB90B4E564E5B CRC64;
MGKLVYHFGA MKAGKSAKLL QMAYQIDGKK SMGIYTTQDS CNHIESRLGI SRSCKHIDEL
FLKPHNKYVK FIFIDECQWL KAHHIKKLRE IADRNETEIH CFGLRSDFKG DTFPASNLLF
LLADEFEHLP SYCDHCDCAA ILHNKQQGEG KEAFESVCYE HFKGEI
//
