ID HAF2_ARCFU Reviewed; 67 AA.
AC O28779;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE RecName: Full=Probable archaeal histone A1-2;
GN Name=hpyA1-2; OrderedLocusNames=AF_1493;
OS Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC
OS 100126 / VC-16).
OC Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae;
OC Archaeoglobus.
OX NCBI_TaxID=224325;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16;
RX PubMed=9389475; DOI=10.1038/37052;
RA Klenk H.-P., Clayton R.A., Tomb J.-F., White O., Nelson K.E., Ketchum K.A.,
RA Dodson R.J., Gwinn M.L., Hickey E.K., Peterson J.D., Richardson D.L.,
RA Kerlavage A.R., Graham D.E., Kyrpides N.C., Fleischmann R.D.,
RA Quackenbush J., Lee N.H., Sutton G.G., Gill S.R., Kirkness E.F.,
RA Dougherty B.A., McKenney K., Adams M.D., Loftus B.J., Peterson S.N.,
RA Reich C.I., McNeil L.K., Badger J.H., Glodek A., Zhou L., Overbeek R.,
RA Gocayne J.D., Weidman J.F., McDonald L.A., Utterback T.R., Cotton M.D.,
RA Spriggs T., Artiach P., Kaine B.P., Sykes S.M., Sadow P.W., D'Andrea K.P.,
RA Bowman C., Fujii C., Garland S.A., Mason T.M., Olsen G.J., Fraser C.M.,
RA Smith H.O., Woese C.R., Venter J.C.;
RT "The complete genome sequence of the hyperthermophilic, sulphate-reducing
RT archaeon Archaeoglobus fulgidus.";
RL Nature 390:364-370(1997).
CC -!- FUNCTION: Binds and compact DNA (95 to 150 base pairs) to form
CC nucleosome-like structures that contain positive DNA supercoils.
CC Increases the resistance of DNA to thermal denaturation (in vitro).
CC {ECO:0000250|UniProtKB:P19267}.
CC -!- SUBUNIT: Homodimer or heterodimer with another histone. Dimers then
CC assemble into higher oligomers, with the DNA wrapped around the protein
CC core (By similarity). {ECO:0000250|UniProtKB:P19267}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Chromosome
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the archaeal histone HMF family. {ECO:0000305}.
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DR EMBL; AE000782; AAB89751.1; -; Genomic_DNA.
DR PIR; D69436; D69436.
DR RefSeq; WP_010878990.1; NC_000917.1.
DR AlphaFoldDB; O28779; -.
DR SMR; O28779; -.
DR STRING; 224325.AF_1493; -.
DR PaxDb; 224325-AF_1493; -.
DR EnsemblBacteria; AAB89751; AAB89751; AF_1493.
DR GeneID; 24795240; -.
DR KEGG; afu:AF_1493; -.
DR eggNOG; arCOG02144; Archaea.
DR HOGENOM; CLU_192667_0_0_2; -.
DR OrthoDB; 7514at2157; -.
DR PhylomeDB; O28779; -.
DR Proteomes; UP000002199; Chromosome.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR InterPro; IPR003958; CBFA_NFYB_domain.
DR InterPro; IPR009072; Histone-fold.
DR PANTHER; PTHR47828:SF1; ARCHAEAL HISTONE 2-RELATED; 1.
DR PANTHER; PTHR47828; ARCHAEAL HISTONE A; 1.
DR Pfam; PF00808; CBFD_NFYB_HMF; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
PE 3: Inferred from homology;
KW Chromosome; Cytoplasm; DNA-binding; Reference proteome.
FT CHAIN 1..67
FT /note="Probable archaeal histone A1-2"
FT /id="PRO_0000154981"
SQ SEQUENCE 67 AA; 7253 MW; 52FA010E696ECD69 CRC64;
MAELPMAPVD RLIRKAGAER VSADAVEKMV EVLEDYAITV AKKAVEIAKH SGRKTVTADD
IKLALSM
//
