ID HBAP1_MOUSE Reviewed; 483 AA.
AC Q8BK58; E9QML8;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 24-JAN-2024, entry version 128.
DE RecName: Full=HSPB1-associated protein 1;
DE AltName: Full=27 kDa heat shock protein-associated protein 1;
DE AltName: Full=Protein associated with small stress protein 1;
GN Name=Hspbap1; Synonyms=Pass1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP INTERACTION WITH CRYAB AND HSPB1.
RX PubMed=10751411; DOI=10.1074/jbc.m001981200;
RA Liu C., Gilmont R.R., Benndorf R., Welsh M.J.;
RT "Identification and characterization of a novel protein from Sertoli cells,
RT PASS1, that associates with mammalian small stress protein hsp27.";
RL J. Biol. Chem. 275:18724-18731(2000).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May play a role in cellular stress response. {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CRYAB and HSPB1. {ECO:0000269|PubMed:10751411}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR EMBL; AK076189; BAC36242.1; -; mRNA.
DR EMBL; AC129574; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS28142.1; -.
DR RefSeq; NP_780320.2; NM_175111.3.
DR AlphaFoldDB; Q8BK58; -.
DR SMR; Q8BK58; -.
DR BioGRID; 211634; 1.
DR STRING; 10090.ENSMUSP00000156217; -.
DR GlyGen; Q8BK58; 1 site, 1 O-linked glycan (1 site).
DR PhosphoSitePlus; Q8BK58; -.
DR SwissPalm; Q8BK58; -.
DR EPD; Q8BK58; -.
DR MaxQB; Q8BK58; -.
DR PaxDb; 10090-ENSMUSP00000023555; -.
DR PeptideAtlas; Q8BK58; -.
DR ProteomicsDB; 269718; -.
DR Pumba; Q8BK58; -.
DR Antibodypedia; 16790; 273 antibodies from 31 providers.
DR DNASU; 66667; -.
DR Ensembl; ENSMUST00000231579.2; ENSMUSP00000156217.2; ENSMUSG00000022849.6.
DR GeneID; 66667; -.
DR KEGG; mmu:66667; -.
DR UCSC; uc007zbq.1; mouse.
DR AGR; MGI:1913917; -.
DR CTD; 79663; -.
DR MGI; MGI:1913917; Hspbap1.
DR VEuPathDB; HostDB:ENSMUSG00000022849; -.
DR eggNOG; KOG2132; Eukaryota.
DR GeneTree; ENSGT00940000159893; -.
DR HOGENOM; CLU_016785_5_1_1; -.
DR InParanoid; Q8BK58; -.
DR OMA; QRMMSKS; -.
DR OrthoDB; 5401772at2759; -.
DR PhylomeDB; Q8BK58; -.
DR TreeFam; TF315056; -.
DR BioGRID-ORCS; 66667; 2 hits in 78 CRISPR screens.
DR ChiTaRS; Hspbap1; mouse.
DR PRO; PR:Q8BK58; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q8BK58; Protein.
DR Bgee; ENSMUSG00000022849; Expressed in ectoplacental cone and 130 other cell types or tissues.
DR ExpressionAtlas; Q8BK58; baseline and differential.
DR Genevisible; Q8BK58; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016706; F:2-oxoglutarate-dependent dioxygenase activity; IBA:GO_Central.
DR Gene3D; 2.60.120.650; Cupin; 1.
DR InterPro; IPR041667; Cupin_8.
DR InterPro; IPR013296; HSPB1-associated_protein_1.
DR InterPro; IPR003347; JmjC_dom.
DR PANTHER; PTHR12461:SF43; HSPB1-ASSOCIATED PROTEIN 1; 1.
DR PANTHER; PTHR12461; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED; 1.
DR Pfam; PF13621; Cupin_8; 1.
DR PRINTS; PR01886; PASS1.
DR SMART; SM00558; JmjC; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 1.
DR PROSITE; PS51184; JMJC; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..483
FT /note="HSPB1-associated protein 1"
FT /id="PRO_0000284114"
FT DOMAIN 124..288
FT /note="JmjC"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00538"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 88..208
FT /note="Interaction with HSPB1"
FT /evidence="ECO:0000250"
FT REGION 388..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 268
FT /note="S -> G (in Ref. 1; BAC36242)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 483 AA; 54395 MW; 520906E6F7F73EBB CRC64;
MAAGCEGIAP PTLGERTVGE EGEPVKPFTP EKAKEIIMSL QQPAIFCNMV FDWPSRHWTA
KHLSKVLEGK QIRFRMGLRG TGTVPQYETE CSYVDATLEE FLTWNCDQSS ISGPFKDYEH
SKFWAYADYK YFVTLFEDKT DVFQEVVWSD FGFPGRNGQE STLWIGSFGA HTPCHLDSYG
CNLVFQVQGR KRWHLFPPED TPFLYPTRIP YEESSVFSKI NVVNPDLKCF PQFQKARRHM
VTLSPGQVLF VPRHWWHYVE SLDPVTVSIN SWIELEEDHL ARVEEAITRM LVCTLKTAED
PHHPRTWLNP TEVEETSHEV NSCYLNSAVC AFFDHCEKAK AVELQVLSAN GAEPRVQEEH
MEVEQAQGPS LTSRAEKQEA VSLFGPDLIP VTPASEERGG ALEGDSEESV SSNGGHFAEL
PCARRQQTSK GASALTEPLA PRGPMAHSRV FVSTDDLLDC LVNPQVTRMV AQLLIQGKSC
DTF
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