ID HELI_HHV6Z Reviewed; 824 AA.
AC P52450;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 24-JAN-2024, entry version 87.
DE RecName: Full=DNA replication helicase {ECO:0000255|HAMAP-Rule:MF_04030};
DE EC=3.6.4.- {ECO:0000255|HAMAP-Rule:MF_04030};
GN Name=HELI {ECO:0000255|HAMAP-Rule:MF_04030}; OrderedLocusNames=CB4R, U77;
OS Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic
OS virus).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Betaherpesvirinae; Roseolovirus;
OC Roseolovirus humanbeta6b; Human herpesvirus 6B.
OX NCBI_TaxID=36351;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8634027; DOI=10.1007/bf01718406;
RA Lindquester G.J., Inoue N., Allen R.D., Castelli J.W., Stamey F.R.,
RA Dambaugh T.R., O'Brian J.J., Danovich R.M., Frenkel N., Pellett P.E.;
RT "Restriction endonuclease mapping and molecular cloning of the human
RT herpesvirus 6 variant B strain Z29 genome.";
RL Arch. Virol. 141:367-379(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10482553; DOI=10.1128/jvi.73.10.8040-8052.1999;
RA Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N.,
RA Pellett P.E.;
RT "Human herpesvirus 6B genome sequence: coding content and comparison with
RT human herpesvirus 6A.";
RL J. Virol. 73:8040-8052(1999).
CC -!- FUNCTION: Component of the helicase/primase complex. Unwinds the DNA at
CC the replication forks and generates single-stranded DNA for both
CC leading and lagging strand synthesis. The primase synthesizes short RNA
CC primers on the lagging strand that the polymerase elongates using
CC dNTPs. Possesses helicase-like motifs and therefore may act as the
CC helicase subunit of the complex. {ECO:0000255|HAMAP-Rule:MF_04030}.
CC -!- SUBUNIT: Associates with the primase and the primase-associated factor
CC to form the helicase-primase complex. {ECO:0000255|HAMAP-
CC Rule:MF_04030}.
CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000255|HAMAP-Rule:MF_04030}.
CC -!- SIMILARITY: Belongs to the herpesviridae helicase family.
CC {ECO:0000255|HAMAP-Rule:MF_04030}.
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DR EMBL; AF157706; AAB06360.1; -; Genomic_DNA.
DR PIR; T44222; T44222.
DR RefSeq; NP_050256.1; NC_000898.1.
DR DNASU; 1497077; -.
DR GeneID; 1497077; -.
DR KEGG; vg:1497077; -.
DR Proteomes; UP000006930; Segment.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0039686; P:bidirectional double-stranded viral DNA replication; IEA:UniProtKB-UniRule.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_04030; HSV_HELI; 1.
DR InterPro; IPR003840; DNA_helicase_dom.
DR InterPro; IPR034711; HSV_HELI.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF02689; Herpes_Helicase; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding; DNA replication; Helicase; Host nucleus; Hydrolase;
KW Nucleotide-binding; Reference proteome.
FT CHAIN 1..824
FT /note="DNA replication helicase"
FT /id="PRO_0000115850"
FT BINDING 90..97
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_04030"
SQ SEQUENCE 824 AA; 93363 MW; ABD0EF62BAA7FBA4 CRC64;
MSISSLFGGR YDNKFLLNMS SAPKIELIVD KVASLSERRL EGRLPEDWFR HIMDPETEFN
GEFADALCIG IDEFAQPLPF LPFKALLVTG TAGAGKTNSI QTLAANLDCI VTATTSIAAQ
NLSVVLNRSK SAQVKTIFKT FGFNSSHVSM SERQSYIAND ERSIQIQQKQ DLSIYWNVIS
DIAERALGAV ACKTKELPDL CESSVIVIDE AGVILRHILH TVVFFYWFYN ALYKTPLYEN
GIVPCIVCVG SPTQSNALVT SFNPLTQNKD VKRGIDVLSA LICDDVLSKY CEVDNNWIIF
VNNKRCADHA FGDFLKHIEF GLPLKPELIE YVDQFVKPAS YIRNPMNEIE TTRLFLSHNE
VKNYFRSLHE QVEVTNRNNL FVFPVYFLIK NKTFEDYKSE IGNFSLEIEP WFKSNIHRLN
TYSQFADQDL SKTVQLEEIV LEDGSVEETL ITCHLKHIRN SSIGVTSKIK ASTVGFSGTY
EKFVELLQSD LFIEKTSCEQ TIHAYSFLSG LMFGGMYSFC CSEFTTPEVL MEIKNIKMPS
IEFLESEMSR MSRDVQTVET DERYDFGLVD DGLSDMDLLE IDPCGDPFFT RYSKLPLTNS
LSFEEISLLY TTFKDIFISR FAILQKHTKG KFGKTLLVTY NRNNVSRKQC GEIYSHLKSF
YGMLTYAIPA NNYTLEGYTN DNVVHLGTDK QLPQILYKKG LPRLVIKDEM GFISVLDNNV
SKFVDVVNGQ SFHLCTTVDY ATVSKVSMTI TKSQGLSIQK VAIDFGSDPK NLKLSSIYVG
MSRVTDPNNL IMNVNPLRLN YENDNFIAPH IVKALKNENT MLIF
//
