ID HPS3_STAS1 Reviewed; 210 AA.
AC Q49VB7;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 27-MAR-2024, entry version 110.
DE RecName: Full=3-hexulose-6-phosphate synthase 3;
DE Short=HPS 3;
DE EC=4.1.2.43;
DE AltName: Full=D-arabino-3-hexulose-6-phosphate formaldehyde lyase 3;
GN OrderedLocusNames=SSP2148;
OS Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS 20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=342451;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT pathogenesis of uncomplicated urinary tract infection.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC -!- FUNCTION: Catalyzes the condensation of ribulose 5-phosphate with
CC formaldehyde to form 3-hexulose 6-phosphate. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-ribulose 5-phosphate + formaldehyde = D-arabino-hex-3-ulose
CC 6-phosphate; Xref=Rhea:RHEA:25201, ChEBI:CHEBI:16842,
CC ChEBI:CHEBI:58121, ChEBI:CHEBI:58542; EC=4.1.2.43;
CC -!- PATHWAY: One-carbon metabolism; formaldehyde assimilation via RuMP
CC pathway; D-fructose 6-phosphate from D-ribulose 5-phosphate and
CC formaldehyde: step 1/2.
CC -!- SIMILARITY: Belongs to the HPS/KGPDC family. HPS subfamily.
CC {ECO:0000305}.
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DR EMBL; AP008934; BAE19293.1; -; Genomic_DNA.
DR RefSeq; WP_011303783.1; NZ_MTGA01000039.1.
DR AlphaFoldDB; Q49VB7; -.
DR SMR; Q49VB7; -.
DR KEGG; ssp:SSP2148; -.
DR PATRIC; fig|342451.11.peg.2139; -.
DR eggNOG; COG0269; Bacteria.
DR HOGENOM; CLU_081825_1_0_9; -.
DR OrthoDB; 43475at2; -.
DR UniPathway; UPA00294; UER00434.
DR Proteomes; UP000006371; Chromosome.
DR GO; GO:0043801; F:hexulose-6-phosphate synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:InterPro.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0019647; P:formaldehyde assimilation via ribulose monophosphate cycle; IEA:UniProtKB-UniPathway.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR CDD; cd04726; KGPDC_HPS; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR017553; 3-hexulose-6-phosphate_synth.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR041710; HPS/KGPDC.
DR InterPro; IPR001754; OMPdeCOase_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR NCBIfam; TIGR03128; RuMP_HxlA; 1.
DR PANTHER; PTHR35039; 3-KETO-L-GULONATE-6-PHOSPHATE DECARBOXYLASE SGBH-RELATED; 1.
DR PANTHER; PTHR35039:SF3; 3-KETO-L-GULONATE-6-PHOSPHATE DECARBOXYLASE SGBH-RELATED; 1.
DR Pfam; PF00215; OMPdecase; 1.
DR SMART; SM00934; OMPdecase; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE 3: Inferred from homology;
KW Carbohydrate metabolism; Lyase; One-carbon metabolism; Reference proteome.
FT CHAIN 1..210
FT /note="3-hexulose-6-phosphate synthase 3"
FT /id="PRO_0000269529"
SQ SEQUENCE 210 AA; 22271 MW; D0A2A8076CCF01FD CRC64;
MELQLAIDLL NKEEAAELAN KVKDYVDIVE IGTPIVINEG LPAVQYLNDN IDGVKVLADL
KIMDAADYEV SQAVKFGADV VTILGVAEDA SIKGAVEEAH KNGKELLVDM IAVQDLQKRA
KELDELGADY IAVHTGYDLQ AEGESPLESL RQVKSVINNS KVAVIGGIKP DTIKEVVAEE
PDLVVVGGGI ANADDPVAAA KACKDAIEGR
//
