ID HRCA_BURCJ Reviewed; 340 AA.
AC B4EDZ7;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN OrderedLocusNames=BceJ2315_32150; ORFNames=BCAL3275;
OS Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 /
OS NCTC 13227 / J2315 / CF5610) (Burkholderia cepacia (strain J2315)).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; Burkholderia cepacia complex.
OX NCBI_TaxID=216591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610;
RX PubMed=18931103; DOI=10.1128/jb.01230-08;
RA Holden M.T., Seth-Smith H.M., Crossman L.C., Sebaihia M., Bentley S.D.,
RA Cerdeno-Tarraga A.M., Thomson N.R., Bason N., Quail M.A., Sharp S.,
RA Cherevach I., Churcher C., Goodhead I., Hauser H., Holroyd N., Mungall K.,
RA Scott P., Walker D., White B., Rose H., Iversen P., Mil-Homens D.,
RA Rocha E.P., Fialho A.M., Baldwin A., Dowson C., Barrell B.G., Govan J.R.,
RA Vandamme P., Hart C.A., Mahenthiralingam E., Parkhill J.;
RT "The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of
RT cystic fibrosis patients.";
RL J. Bacteriol. 191:261-277(2009).
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC Rule:MF_00081}.
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DR EMBL; AM747720; CAR53599.1; -; Genomic_DNA.
DR RefSeq; WP_006484956.1; NC_011000.1.
DR AlphaFoldDB; B4EDZ7; -.
DR SMR; B4EDZ7; -.
DR GeneID; 56557184; -.
DR KEGG; bcj:BCAL3275; -.
DR eggNOG; COG1420; Bacteria.
DR HOGENOM; CLU_050019_0_0_4; -.
DR BioCyc; BCEN216591:G1G1V-3647-MONOMER; -.
DR Proteomes; UP000001035; Chromosome 1.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR NCBIfam; TIGR00331; hrcA; 1.
DR PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR Pfam; PF01628; HrcA; 1.
DR Pfam; PF03444; HrcA_DNA-bdg; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Repressor; Stress response; Transcription; Transcription regulation.
FT CHAIN 1..340
FT /note="Heat-inducible transcription repressor HrcA"
FT /id="PRO_1000092797"
SQ SEQUENCE 340 AA; 37381 MW; 7D810408C815467D CRC64;
MLDPRARTLL KTLIERYIAD GQPVGSRTLS RYSGLELSPA TIRNVMSDLE ELGLVSSPHT
SAGRIPTPRG YRLFVDTMLT VEAPIDAEAV ARQVQNTLQA GEPQQRVVAA AASVLSNLSQ
FAGVVLTPRR SHVFKQIEFM RLSDKRILLI IVTPEGDVQN RMLATPRDYS PSQLTEASNY
INAHFAGLSF DEVRRRLRDE IDQLRGDMTT LMHAAVTAST EVPDTEDTVL ISGERNLLEV
ADLSSDMARL RKLFDVFDQK TGLLQLLDVS SHAQGVQIFI GGESTLVPIE EMSVVTAPYE
VNGKIVGTLG VIGPTRMAYN RVIPIVDITA RLLSLTLSQQ
//
