ID HRCA_EXISA Reviewed; 340 AA.
AC C4L427;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 07-JUL-2009, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=EAT1b_0618;
OS Exiguobacterium sp. (strain ATCC BAA-1283 / AT1b).
OC Bacteria; Bacillota; Bacilli; Bacillales;
OC Bacillales Family XII. Incertae Sedis; Exiguobacterium.
OX NCBI_TaxID=360911;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1283 / AT1b;
RX PubMed=21460088; DOI=10.1128/jb.00303-11;
RA Vishnivetskaya T.A., Lucas S., Copeland A., Lapidus A., Glavina del Rio T.,
RA Dalin E., Tice H., Bruce D.C., Goodwin L.A., Pitluck S., Saunders E.,
RA Brettin T., Detter C., Han C., Larimer F., Land M.L., Hauser L.J.,
RA Kyrpides N.C., Ovchinnikova G., Kathariou S., Ramaley R.F., Rodrigues D.F.,
RA Hendrix C., Richardson P., Tiedje J.M.;
RT "Complete genome sequence of the Thermophilic Bacterium Exiguobacterium sp.
RT AT1b.";
RL J. Bacteriol. 193:2880-2881(2011).
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC Rule:MF_00081}.
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DR EMBL; CP001615; ACQ69549.1; -; Genomic_DNA.
DR RefSeq; WP_012726668.1; NC_012673.1.
DR AlphaFoldDB; C4L427; -.
DR SMR; C4L427; -.
DR STRING; 360911.EAT1b_0618; -.
DR KEGG; eat:EAT1b_0618; -.
DR eggNOG; COG1420; Bacteria.
DR HOGENOM; CLU_050019_1_0_9; -.
DR OrthoDB; 9783139at2; -.
DR Proteomes; UP000000716; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR NCBIfam; TIGR00331; hrcA; 1.
DR PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR Pfam; PF01628; HrcA; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Repressor; Stress response; Transcription; Transcription regulation.
FT CHAIN 1..340
FT /note="Heat-inducible transcription repressor HrcA"
FT /id="PRO_1000202550"
SQ SEQUENCE 340 AA; 38779 MW; DFD78678E05FA776 CRC64;
MLTDRQLLIL RAIIDDYIQT AQPVGSRTLS KRDDLTFSSA TIRNDMADLE DMGLIEKPHT
SAGRIPSEVG YRYYVDHLVE KQIIDERETG RLEERLKQSS KESEILIRQA ADLLSDLTNY
TTVALGPNSQ METLARVDFM PLDERRGVVL IVTDQGHVEH RTVMFESRVA PDVIEETIRL
LNDRLVGTPI GQLKIRIGEE VAKLQLAQRQ QYENMMQLIQ STVGIQTPSS LYLGGKKKIF
NQPEFQTLDT LRPFLEWIDE QERLTHWLES LPNREIYVSI GSENGIVALQ NCSVITSDYT
LDGKTFGTIA MIGPTRMNYR HGVQMMGQII EALRRTKLDE
//
