ID HRCA_LACLA Reviewed; 347 AA.
AC Q9CGZ0;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 27-APR-2001, sequence version 1.
DT 27-MAR-2024, entry version 118.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=LL0952;
GN ORFNames=L0212;
OS Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus.
OX NCBI_TaxID=272623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL1403;
RX PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA Ehrlich S.D., Sorokin A.;
RT "The complete genome sequence of the lactic acid bacterium Lactococcus
RT lactis ssp. lactis IL1403.";
RL Genome Res. 11:731-753(2001).
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC Rule:MF_00081}.
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DR EMBL; AE005176; AAK05050.1; -; Genomic_DNA.
DR PIR; H86743; H86743.
DR RefSeq; NP_267108.1; NC_002662.1.
DR RefSeq; WP_010905650.1; NC_002662.1.
DR AlphaFoldDB; Q9CGZ0; -.
DR SMR; Q9CGZ0; -.
DR PaxDb; 272623-L0212; -.
DR EnsemblBacteria; AAK05050; AAK05050; L0212.
DR KEGG; lla:L0212; -.
DR PATRIC; fig|272623.7.peg.1019; -.
DR eggNOG; COG1420; Bacteria.
DR HOGENOM; CLU_050019_1_0_9; -.
DR OrthoDB; 9783139at2; -.
DR Proteomes; UP000002196; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR005104; WHTH_HrcA_DNA-bd.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR NCBIfam; TIGR00331; hrcA; 1.
DR PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR Pfam; PF01628; HrcA; 1.
DR Pfam; PF03444; HrcA_DNA-bdg; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome; Repressor; Stress response; Transcription;
KW Transcription regulation.
FT CHAIN 1..347
FT /note="Heat-inducible transcription repressor HrcA"
FT /id="PRO_0000182487"
SQ SEQUENCE 347 AA; 39863 MW; 04F2E19C1D300430 CRC64;
MITERQRQIL NLIVSLYAKE HTPIGSKSLL DSIQASSATI RNDMKVLEKL GLIQKEHTSS
GRVPSVSGYK YFVENVIQLD EFSQNDLFKV MKAFDGDFYR LSDLFKTAAK SLSGLTGLTS
FVLNAPQRDQ QLVSFEMVML DSHSVLSVIT LGTGEVRTNQ FILPKSMTEA DLAVFSNLVK
ERLVGKKVID IHYTLRTEIP QIVQRYFKVT SEVLQLFESI FDDLFKERLT VAGRKNIFDY
ATDNLAELYK LFSDDERMLH EIREITNNDE MRAVKFDNDE KYMKNLTIIS QKFVIPYRGF
GTLTVVGPVE MDYQRTLSVL DLVAKVLTMK LSDYYRYLDG NHYEISK
//
