ID HRCA_SINFN Reviewed; 359 AA.
AC C3MEJ2;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081}; OrderedLocusNames=NGR_c00110;
OS Sinorhizobium fredii (strain NBRC 101917 / NGR234).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX NCBI_TaxID=394;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 101917 / NGR234;
RX PubMed=19376903; DOI=10.1128/aem.00515-09;
RA Schmeisser C., Liesegang H., Krysciak D., Bakkou N., Le Quere A.,
RA Wollherr A., Heinemeyer I., Morgenstern B., Pommerening-Roeser A.,
RA Flores M., Palacios R., Brenner S., Gottschalk G., Schmitz R.A.,
RA Broughton W.J., Perret X., Strittmatter A.W., Streit W.R.;
RT "Rhizobium sp. strain NGR234 possesses a remarkable number of secretion
RT systems.";
RL Appl. Environ. Microbiol. 75:4035-4045(2009).
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC Rule:MF_00081}.
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DR EMBL; CP001389; ACP23815.1; -; Genomic_DNA.
DR RefSeq; WP_012706600.1; NC_012587.1.
DR RefSeq; YP_002824568.1; NC_012587.1.
DR AlphaFoldDB; C3MEJ2; -.
DR SMR; C3MEJ2; -.
DR STRING; 394.NGR_c00110; -.
DR KEGG; rhi:NGR_c00110; -.
DR PATRIC; fig|394.7.peg.2801; -.
DR eggNOG; COG1420; Bacteria.
DR HOGENOM; CLU_050019_0_0_5; -.
DR OrthoDB; 9783139at2; -.
DR Proteomes; UP000001054; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR NCBIfam; TIGR00331; hrcA; 1.
DR PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR Pfam; PF01628; HrcA; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome; Repressor; Stress response; Transcription;
KW Transcription regulation.
FT CHAIN 1..359
FT /note="Heat-inducible transcription repressor HrcA"
FT /id="PRO_1000118312"
SQ SEQUENCE 359 AA; 39413 MW; 6296EE27CE3B3D19 CRC64;
MVLRNPEKKG IASTLDERSG EIFRRIVETY LESGEPLGSR NLSRLLPMSL SPASVRNVMS
DLEDLGLIYS PHVSAGRLPT QTGLRFFVDA FMQVGNLSAE ERTSIERQVR RADRDQPIDS
LLAEASQMLS GMSRGAGLVI TTKSDPVLKH VEFIRLAPTK ALAVLVGDHD QVENRIIELP
AGITSAQLTE AANFVNAHLA GQTIPELRSQ LEKVKETVRG ELDALSQDLV ERGLAIWSGS
EGDEKPARLI VRGRANLLEG LEGTEDIERL RMLFDDLEKK DSLIELLDLA ESGPGVRIFI
GSENKLFSLS GSSLIVAPYR DSDDRIVGAV GVIGPTRLNY SRIVPMVDYT AQLMSRLSR
//
