ID HRCA_SYNE7 Reviewed; 353 AA.
AC Q31QM1;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE RecName: Full=Heat-inducible transcription repressor HrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN Name=hrcA {ECO:0000255|HAMAP-Rule:MF_00081};
GN OrderedLocusNames=Synpcc7942_0616;
OS Synechococcus elongatus (strain ATCC 33912 / PCC 7942 / FACHB-805)
OS (Anacystis nidulans R2).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales; Synechococcaceae;
OC Synechococcus.
OX NCBI_TaxID=1140;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 33912 / PCC 7942 / FACHB-805;
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M.,
RA Kyrpides N., Lykidis A., Golden S., Richardson P.;
RT "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942.";
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Negative regulator of class I heat shock genes (grpE-dnaK-
CC dnaJ and groELS operons). Prevents heat-shock induction of these
CC operons. {ECO:0000255|HAMAP-Rule:MF_00081}.
CC -!- SIMILARITY: Belongs to the HrcA family. {ECO:0000255|HAMAP-
CC Rule:MF_00081}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000100; ABB56648.1; -; Genomic_DNA.
DR RefSeq; WP_011243220.1; NZ_JACJTX010000006.1.
DR AlphaFoldDB; Q31QM1; -.
DR SMR; Q31QM1; -.
DR STRING; 1140.Synpcc7942_0616; -.
DR PaxDb; 1140-Synpcc7942_0616; -.
DR GeneID; 76399364; -.
DR KEGG; syf:Synpcc7942_0616; -.
DR eggNOG; COG1420; Bacteria.
DR HOGENOM; CLU_050019_2_0_3; -.
DR OrthoDB; 9783139at2; -.
DR BioCyc; SYNEL:SYNPCC7942_0616-MONOMER; -.
DR Proteomes; UP000889800; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR HAMAP; MF_00081; HrcA; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR002571; HrcA.
DR InterPro; IPR021153; HrcA_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR023120; WHTH_transcript_rep_HrcA_IDD.
DR NCBIfam; TIGR00331; hrcA; 1.
DR PANTHER; PTHR34824; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR PANTHER; PTHR34824:SF1; HEAT-INDUCIBLE TRANSCRIPTION REPRESSOR HRCA; 1.
DR Pfam; PF01628; HrcA; 1.
DR PIRSF; PIRSF005485; HrcA; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome; Repressor; Stress response; Transcription;
KW Transcription regulation.
FT CHAIN 1..353
FT /note="Heat-inducible transcription repressor HrcA"
FT /id="PRO_1000010470"
SQ SEQUENCE 353 AA; 38806 MW; 54379761C9C48F98 CRC64;
MLVSRLTARQ QTILSATVRH YVRTAEPVGS KALAEQYGLS VSAATIRNAM GVLERAGLLY
QPHTSAGRVP SEGGYRLYVD QLMEPDRALQ RQTEQQLSQQ LPDRRQSLEA LLRGAAQILA
SLSGYLSLIT FPLGLEFQVR HLQLVAIAPH QVLLIVVNDS YETQSALLTL PELDRDLEAD
QLDRQLLLLS NFLNQELQGR SLQALANLDW PVLGSELQSL AGILQQGLQD LEKRWQPTPA
TSLLVCGLAD LLRQPEFNEL QQVQALLELL EGEQTQLLPL MLADPAADQV RVRIGSELPL
APIRSCSLVS AFYCREQQPV GSVSLIGPTR MLYENAVAAV EATASYLSEA IAS
//
