ID HRTB_STAA8 Reviewed; 351 AA.
AC Q2FVR0;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2006, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=Putative hemin transport system permease protein HrtB;
GN Name=hrtB; OrderedLocusNames=SAOUHSC_02641;
OS Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC Bacteria; Bacillota; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=93061;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC 8325 / PS 47;
RA Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT "The Staphylococcus aureus NCTC 8325 genome.";
RL (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL D.C. (2006).
CC -!- FUNCTION: Part of the ABC transporter complex hrt involved in hemin
CC import. Responsible for the translocation of the substrate across the
CC membrane (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (HrtA),
CC two transmembrane proteins (HrtB) and a solute-binding protein.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC-4 integral membrane protein family. HrtB
CC subfamily. {ECO:0000305}.
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DR EMBL; CP000253; ABD31650.1; -; Genomic_DNA.
DR RefSeq; WP_000761395.1; NZ_LS483365.1.
DR RefSeq; YP_501104.1; NC_007795.1.
DR AlphaFoldDB; Q2FVR0; -.
DR SMR; Q2FVR0; -.
DR STRING; 93061.SAOUHSC_02641; -.
DR PaxDb; 1280-SAXN108_2612; -.
DR GeneID; 3921418; -.
DR KEGG; sao:SAOUHSC_02641; -.
DR PATRIC; fig|93061.5.peg.2389; -.
DR eggNOG; COG0577; Bacteria.
DR HOGENOM; CLU_060907_1_0_9; -.
DR OrthoDB; 384327at2; -.
DR PRO; PR:Q2FVR0; -.
DR Proteomes; UP000008816; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR003838; ABC3_permease_dom.
DR PANTHER; PTHR43738; ABC TRANSPORTER, MEMBRANE PROTEIN; 1.
DR PANTHER; PTHR43738:SF1; HEMIN TRANSPORT SYSTEM PERMEASE PROTEIN HRTB-RELATED; 1.
DR Pfam; PF02687; FtsX; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..351
FT /note="Putative hemin transport system permease protein
FT HrtB"
FT /id="PRO_0000270522"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 281..301
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 351 AA; 39482 MW; 2409D3B9BF82ADC8 CRC64;
MKLAIKEIMF YKFRYILITL IILLLSIMVL FISGLAQGLG RENISLFEHF DNDEYVVQKM
KEPQIEKSQL SDTQQNQIKK VIHQEPYKMN IQTLKLSNKE QDVITMNDVK QQRIQLKKGD
YPKNAHEVAI NDKLAADNIR VGDRLHFKNN STSYRVSGIL NDTMYAHSSI VLLNDNGFNA
LNKVNTAFYP VKNLTQQQRD ELNKINDVQV VSEKDLTGNI ASYQAEQAPL NMMIVSLFAI
TAIVLSAFFY VMTIQKISQI GILKAIGIKT RHLLSALVLQ ILTLTIIGVG IAVIIIVGLS
FMMPVTMPFY LTTQNILLMV GIFILVAILG ASLSFIKLFK VDPIEAIGGA E
//
