ID HSP88_NEUCR Reviewed; 707 AA.
AC O74225; Q7RVE6; V5IPJ6;
DT 01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 24-JAN-2024, entry version 122.
DE RecName: Full=Heat shock protein hsp88;
GN Name=hsp88; ORFNames=NCU05269;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 431-436; 439-445; 536-549;
RP 575-586; 596-602 AND 689-697, AND CHARACTERIZATION.
RX PubMed=9556627; DOI=10.1074/jbc.273.18.11335;
RA Plesofsky-Vig N., Brambl R.;
RT "Characterization of an 88-kDa heat shock protein of Neurospora crassa that
RT interacts with Hsp30.";
RL J. Biol. Chem. 273:11335-11341(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- SUBUNIT: Binds hsp30 independent of temperature or substrate.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- INDUCTION: By heat shock.
CC -!- PTM: The N-terminus is blocked.
CC -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR EMBL; AF069523; AAC23862.1; -; mRNA.
DR EMBL; CM002239; ESA43073.1; -; Genomic_DNA.
DR EMBL; CM002239; ESA43074.1; -; Genomic_DNA.
DR RefSeq; XP_011394150.1; XM_011395848.1.
DR RefSeq; XP_011394151.1; XM_011395849.1.
DR AlphaFoldDB; O74225; -.
DR SMR; O74225; -.
DR STRING; 367110.O74225; -.
DR PaxDb; 5141-EFNCRP00000005028; -.
DR EnsemblFungi; ESA43073; ESA43073; NCU05269.
DR EnsemblFungi; ESA43074; ESA43074; NCU05269.
DR GeneID; 3877907; -.
DR KEGG; ncr:NCU05269; -.
DR VEuPathDB; FungiDB:NCU05269; -.
DR HOGENOM; CLU_005965_5_1_1; -.
DR InParanoid; O74225; -.
DR OrthoDB; 276440at2759; -.
DR Proteomes; UP000001805; Chromosome 4, Linkage Group IV.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000774; F:adenyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR CDD; cd10228; HSPA4_like_NDB; 1.
DR Gene3D; 1.20.1270.10; -; 1.
DR Gene3D; 3.30.30.30; -; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018181; Heat_shock_70_CS.
DR InterPro; IPR029048; HSP70_C_sf.
DR InterPro; IPR029047; HSP70_peptide-bd_sf.
DR InterPro; IPR013126; Hsp_70_fam.
DR PANTHER; PTHR45639:SF4; HSC70CB, ISOFORM G; 1.
DR PANTHER; PTHR45639; HSC70CB, ISOFORM G-RELATED; 1.
DR Pfam; PF00012; HSP70; 1.
DR PRINTS; PR00301; HEATSHOCK70.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR SUPFAM; SSF100934; Heat shock protein 70kD (HSP70), C-terminal subdomain; 1.
DR SUPFAM; SSF100920; Heat shock protein 70kD (HSP70), peptide-binding domain; 1.
DR PROSITE; PS01036; HSP70_3; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Cytoplasm; Direct protein sequencing; Nucleotide-binding;
KW Reference proteome; Stress response.
FT CHAIN 1..707
FT /note="Heat shock protein hsp88"
FT /id="PRO_0000078373"
FT REGION 662..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 707 AA; 78674 MW; 8B077E8CC08BB4C1 CRC64;
MSVVGVDFGA LNTVIAVARN RGVDVITNEV SNRATPSLVG FGPKSRYIGE PAKTQEISNL
KNTVGCLKRL AGRTLDDPDV AIEQQFISAT LVDVNGEVGA EVTYLGEKRK FSATELIAMF
MSKIKQTTQA EVKVAVQELV LSVPAWFTDK QRRSILDAAE IAGLRPLRLI NDTTAAALGW
GITKLDLPGP EEKPRRVAFV DVGYSNYTCS IVEFKKGELS VKSTACDRHF GGRNFDKALL
DHLHKEFLGK YKIDIFTNPK AVCRVLAAAE KLKKILSANQ QAPLNIESLM NDIDVRAMIT
RQEFEAMVEP LLAKVHVPLE QALADAKLTK DDIDIIEVVG GGSRVPSVKE RIQAFFGKQL
SFTMNQDEAI ARGCAFSCAI LSPVFKVRDF QVQDIINYPI EFTWEKDADI PDEDTSLVVF
NKGNVLPSTK ILTFYRKQPF DLEARYTNPE ELPGKTSPFI GRFSIKGVHA TEGPEDFMIC
KLKARINIHG ILNVESAYYV EDQEVEEEVK DENGDVVMEG DKPKTRKVKK QVRKGELPVV
SATPSLDPAA KNAAIEREQA MIMEDKLVAD TEEKKNELET YIYDLRNKLD DQYADLASEE
EKEKIRAKLM EVEDWLYDEG DDATKAVYVA KIEEIRALAG PVVQRYFDKV EAERQALQEK
LEAEKAAKKA EEEARKAKEA AEKAAQEGAK DDEMTDADAP KPVVEEA
//
