ID HUTM_BACSU Reviewed; 475 AA.
AC P42087;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 28-JUL-2009, sequence version 2.
DT 27-MAR-2024, entry version 134.
DE RecName: Full=Putative histidine permease;
GN Name=hutM; OrderedLocusNames=BSU39390; ORFNames=EE57D;
OS Bacillus subtilis (strain 168).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / BGSC1A1;
RX PubMed=7704263; DOI=10.1099/13500872-141-2-337;
RA Yoshida K., Sano H., Seki S., Oda M., Fujimura M., Fujita Y.;
RT "Cloning and sequencing of a 29 kb region of the Bacillus subtilis genome
RT containing the hut and wapA loci.";
RL Microbiology 141:337-343(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP SEQUENCE REVISION TO 74-75.
RX PubMed=19383706; DOI=10.1099/mic.0.027839-0;
RA Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A.,
RA Vallenet D., Wang T., Moszer I., Medigue C., Danchin A.;
RT "From a consortium sequence to a unified sequence: the Bacillus subtilis
RT 168 reference genome a decade later.";
RL Microbiology 155:1758-1775(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 360-475.
RC STRAIN=168;
RX PubMed=8550462; DOI=10.1128/jb.178.2.424-434.1996;
RA Saxild H.H., Andersen L.N., Hammer K.;
RT "Dra-nupC-pdp operon of Bacillus subtilis: nucleotide sequence, induction
RT by deoxyribonucleosides, and transcriptional regulation by the deoR-encoded
RT DeoR repressor protein.";
RL J. Bacteriol. 178:424-434(1996).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 361-475.
RC STRAIN=168 / BGSC1A1;
RX PubMed=8867804; DOI=10.1093/dnares/2.6.295;
RA Yoshida K., Fujimyra M., Yanai N., Fujita Y.;
RT "Cloning and sequencing of a 23-kb region of the Bacillus subtilis genome
RT between the iol and hut operons.";
RL DNA Res. 2:295-301(1995).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC superfamily. {ECO:0000305}.
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DR EMBL; D31856; BAA06640.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB15975.2; -; Genomic_DNA.
DR EMBL; X82174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; D45912; BAA08340.1; -; Genomic_DNA.
DR PIR; E69643; E69643.
DR RefSeq; NP_391818.2; NC_000964.3.
DR RefSeq; WP_003227134.1; NZ_JNCM01000034.1.
DR AlphaFoldDB; P42087; -.
DR SMR; P42087; -.
DR STRING; 224308.BSU39390; -.
DR PaxDb; 224308-BSU39390; -.
DR EnsemblBacteria; CAB15975; CAB15975; BSU_39390.
DR GeneID; 938565; -.
DR KEGG; bsu:BSU39390; -.
DR PATRIC; fig|224308.179.peg.4264; -.
DR eggNOG; COG0833; Bacteria.
DR InParanoid; P42087; -.
DR OrthoDB; 9780162at2; -.
DR PhylomeDB; P42087; -.
DR BioCyc; BSUB:BSU39390-MONOMER; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015171; F:amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR004840; Amoino_acid_permease_CS.
DR PANTHER; PTHR43495; GABA PERMEASE; 1.
DR PANTHER; PTHR43495:SF5; GAMMA-AMINOBUTYRIC ACID PERMEASE; 1.
DR Pfam; PF00324; AA_permease; 1.
DR PIRSF; PIRSF006060; AA_transporter; 1.
DR PROSITE; PS00218; AMINO_ACID_PERMEASE_1; 1.
PE 3: Inferred from homology;
KW Amino-acid transport; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..475
FT /note="Putative histidine permease"
FT /id="PRO_0000054203"
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 127..147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 162..182
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 341..361
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 363..383
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 434..454
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 74..75
FT /note="MP -> NA (in Ref. 1; BAA06640)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 475 AA; 51624 MW; CD686DE3B71CA7FF CRC64;
MNLQENSSQQ LKRTMKSRHL FMISLGGVIG TGLFLSTGYT LHQAGPGGTI LAYVIGGLMM
YLVMQCLGEL SVAMPVTGSF QKYATTFIGP STGFMVGIMY WINWVVTVGS EFTASGILMQ
RWFPDSSVWM WSAIFAALLF ICNAFSVKLF AETEFWFSSV KIVTIILFII LGGAAMFGLI
SLNGTADAPM LSNFTDHGGL FPNGFLAVFI AMISVSFAFS GTELIGVTAG ESANPQKDIP
RSIRNVAWRT VIFFIGAVFI LSGLISWKDA GVIESPFVAV FAEIGIPYAA DIMNFVILTA
LLSVANSGLY ASTRMMWSLA NENMISSRFK KVTSKGIPLN ALMISMAVSC LSLVSSIVAP
GTVYVVMVAI AGFAGVVVWM SIALSQLLFR KRFLKKGGDV KDLTFRTPLY PLMPIAALLL
CSASCIGLAF DPNQRIALFC GVPCIILCYL IYHFKRNVTK AKKISQEEYP ADHIL
//
