ID HXA7_PANTR Reviewed; 230 AA.
AC A2T7F3;
DT 01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-MAR-2007, sequence version 1.
DT 08-NOV-2023, entry version 80.
DE RecName: Full=Homeobox protein Hox-A7;
GN Name=HOXA7;
OS Pan troglodytes (Chimpanzee).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Pan.
OX NCBI_TaxID=9598;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Nickel G.C., Tefft D.L., Trevarthen K., Funt J., Adams M.D.;
RT "Positive selection in transcription factor genes on the human lineage.";
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; DQ977437; ABM92108.1; -; Genomic_DNA.
DR RefSeq; NP_001129067.1; NM_001135595.1.
DR STRING; 9598.ENSPTRP00000032500; -.
DR PaxDb; 9598-ENSPTRP00000032500; -.
DR GeneID; 745634; -.
DR KEGG; ptr:745634; -.
DR CTD; 3204; -.
DR eggNOG; KOG0489; Eukaryota.
DR InParanoid; A2T7F3; -.
DR OrthoDB; 728401at2759; -.
DR Proteomes; UP000002277; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017995; Homeobox_antennapedia.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR45659; HOMEOBOX PROTEIN HOX; 1.
DR PANTHER; PTHR45659:SF12; HOMEOBOX PROTEIN HOX-A7; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00025; ANTENNAPEDIA.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..230
FT /note="Homeobox protein Hox-A7"
FT /id="PRO_0000285421"
FT DNA_BIND 130..189
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 187..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 119..124
FT /note="Antp-type hexapeptide"
FT COMPBIAS 215..230
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 230 AA; 25294 MW; 4284CF2D0ECEC564 CRC64;
MSSSYYVNAL FSKYTAGASL FQNAEPTSCS FAPNSQRSGY GAGAGAFAST VPGLYNVNSP
LYXSPFASGY GLGADAYGNL PCASYDQNIP GLCSDLAKGA CDKADEGALH GAAEANFRIY
PWMRSSGPDR KRGRQTYTRY QTLELEKEFH FNRYLTRRRR IEIAHALCLT ERQIKIWFQN
RRMKWKKEHK DDGPTAAAAP EGAVPSAAAT AAADKADEED DDEEEEDEEE
//
