ID HXCDA_DANRE Reviewed; 306 AA.
AC Q6JIY5; Q4PR83; Q9YGS9;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE RecName: Full=Homeobox protein Hox-C13a;
GN Name=hoxc13a;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo;
RX PubMed=15385162; DOI=10.1016/j.ydbio.2004.07.018;
RA Thummel R., Li L., Tanase C., Sarras M.P. Jr., Godwin A.R.;
RT "Differences in expression pattern and function between zebrafish hoxc13
RT orthologs: recruitment of Hoxc13b into an early embryonic role.";
RL Dev. Biol. 274:318-333(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 116-235.
RC STRAIN=Tuebingen;
RX PubMed=16174031; DOI=10.1111/j.1525-142x.2005.05042.x;
RA Corredor-Adamez M., Welten M.C.M., Spaink H.P., Jeffery J.E., Schoon R.T.,
RA de Bakker M.A.G., Bagowski C.P., Meijer A.H., Verbeek F.J.,
RA Richardson M.K.;
RT "Genomic annotation and transcriptome analysis of the zebrafish (Danio
RT rerio) hox complex with description of a novel member, hoxb13a.";
RL Evol. Dev. 7:362-375(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 236-306.
RX PubMed=9831563; DOI=10.1126/science.282.5394.1711;
RA Amores A., Force A., Yan Y.-L., Joly L., Amemiya C., Fritz A., Ho R.K.,
RA Langeland J., Prince V.E., Wang Y.-L., Westerfield M., Ekker M.,
RA Postlethwait J.H.;
RT "Zebrafish hox clusters and vertebrate genome evolution.";
RL Science 282:1711-1714(1998).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- DEVELOPMENTAL STAGE: First detected in the posterior tail bud at around
CC 16.5 hours post-fertilization (hpf), expression continuing through to
CC 36 hpf. Expressed in the developing fin fold and neural tube from 48-72
CC hpf. {ECO:0000269|PubMed:15385162}.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR EMBL; AY452737; AAS16937.1; -; mRNA.
DR EMBL; DQ060560; AAY67938.1; -; mRNA.
DR EMBL; AF071261; AAD15954.1; -; Genomic_DNA.
DR RefSeq; NP_571618.1; NM_131543.1.
DR AlphaFoldDB; Q6JIY5; -.
DR SMR; Q6JIY5; -.
DR STRING; 7955.ENSDARP00000093923; -.
DR PaxDb; 7955-ENSDARP00000093923; -.
DR GeneID; 58059; -.
DR KEGG; dre:58059; -.
DR AGR; ZFIN:ZDB-GENE-000822-4; -.
DR CTD; 58059; -.
DR ZFIN; ZDB-GENE-000822-4; hoxc13a.
DR eggNOG; KOG0487; Eukaryota.
DR InParanoid; Q6JIY5; -.
DR OrthoDB; 728401at2759; -.
DR PhylomeDB; Q6JIY5; -.
DR PRO; PR:Q6JIY5; -.
DR Proteomes; UP000000437; Chromosome 23.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0031101; P:fin regeneration; IMP:ZFIN.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR022067; HoxA13_N.
DR PANTHER; PTHR45804:SF5; HOMEOBOX PROTEIN HOX-C13; 1.
DR PANTHER; PTHR45804; SEGMENTATION PROTEIN FUSHI TARAZU-LIKE PROTEIN; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF12284; HoxA13_N; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..306
FT /note="Homeobox protein Hox-C13a"
FT /id="PRO_0000200199"
FT DNA_BIND 236..295
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT CONFLICT 154
FT /note="L -> F (in Ref. 2; AAY67938)"
FT /evidence="ECO:0000305"
FT CONFLICT 175
FT /note="V -> A (in Ref. 2; AAY67938)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 306 AA; 34701 MW; FAB3B422EACDCC78 CRC64;
MTTSQVLHPR WADTLMYVYE KSPNENNQNK SQIMEGLSGN CPATHCRELI SHPALGRHSG
TIATHQGSVY SDISSPETGR QCPAPQTSSS ASLSYGYPFG NPYYGCRLSH SHNVNLQQKP
CSYHPAEKYA ETSSALPTEE LSSRAKEFAF YPSLASSYQA VPGYLDMSVV PSISVHPEPR
HDALIPMEGY QHWALSNGWD GQVYCSKEQT QSSHLWKSPF PDVVPLQPEV SSYRRGRKKR
VPYTKIQLKE LEKEYAASKF ITKDKRRRIS ATTNLSERQV TIWFQNRRVK EKKFVSKSKT
NNHMHT
//
