ID HXD3_ORYLA Reviewed; 395 AA.
AC Q3V5Z9;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 22-FEB-2023, entry version 99.
DE RecName: Full=Homeobox protein Hox-D3;
GN Name=hoxd3a;
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Hd-rR;
RX PubMed=16472944; DOI=10.1016/j.gene.2005.11.015;
RA Kurosawa G., Takamatsu N., Takahashi M., Sumitomo M., Sanaka E., Yamada K.,
RA Nishii K., Matsuda M., Asakawa S., Ishiguro H., Miura K., Kurosawa Y.,
RA Shimizu N., Kohara Y., Hori H.;
RT "Organization and structure of hox gene loci in medaka genome and
RT comparison with those of pufferfish and zebrafish genomes.";
RL Gene 370:75-82(2006).
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR EMBL; AB208013; BAE44287.1; -; Genomic_DNA.
DR EMBL; AB232923; BAE53501.1; -; Genomic_DNA.
DR AlphaFoldDB; Q3V5Z9; -.
DR SMR; Q3V5Z9; -.
DR STRING; 8090.ENSORLP00000021951; -.
DR eggNOG; KOG0489; Eukaryota.
DR InParanoid; Q3V5Z9; -.
DR Proteomes; UP000001038; Unplaced.
DR Proteomes; UP000265180; Chromosome 9.
DR Proteomes; UP000265200; Chromosome 9.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR025281; DUF4074.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR PANTHER; PTHR45664:SF5; HOMEOBOX PROTEIN HOX-D3; 1.
DR PANTHER; PTHR45664; PROTEIN ZERKNUELLT 1-RELATED; 1.
DR Pfam; PF13293; DUF4074; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00032; ANTENNAPEDIA; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..395
FT /note="Homeobox protein Hox-D3"
FT /id="PRO_0000363947"
FT DNA_BIND 160..219
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 135..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 217..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 128..133
FT /note="Antp-type hexapeptide"
FT COMPBIAS 66..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..387
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 395 AA; 42794 MW; A7E44CE171E912A5 CRC64;
MQKATYYDNS GLFGGYSYPK PDSYSYGPAH QSYPTANIES DYQGPVCPIQ TPAVRPPALK
DTDLNGDCMR QSSSQSSNSG TQAGSISEQQ APPLSASPPS SNSSASQKKK SPSGGASGAA
TPALTKQIFP WMKETRQNSK QKSNNCGEVS DEKSPPGPAS KRVRTAYTSA QLVELEKEFH
FNRYLCRPRR VEMANLLNLT ERQIKIWFQN RRMKYKKDQK SKGLAHSPLG HSPDRSPPLS
GPNHVGYSGQ LQNVNSLSYD APSPPSFAKP QQNMYGLAAY TAPLGGCIPQ QKRYPGSEYE
HHGMQSNGGF ANANLQGSPV YVGGNFVDSM PASGPMFNLG HLPHPSSTSV DYSCAAQIPG
NHHHGPCDPH PTYTDLTSHQ ASQGRIQEAP KLTHL
//
