ID HXD9_ORYLA Reviewed; 271 AA.
AC Q9PVR2;
DT 27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 24-JAN-2024, entry version 111.
DE RecName: Full=Homeobox protein Hox-D9;
GN Name=hoxd9; Synonyms=hoxd9a;
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Kondo S., Naruse K., Shima A.;
RT "Hox genes of the medakafish Oryzias latipes.";
RL Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC developmental regulatory system that provides cells with specific
CC positional identities on the anterior-posterior axis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- SIMILARITY: Belongs to the Abd-B homeobox family. {ECO:0000305}.
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DR EMBL; AB026967; BAA86250.1; -; mRNA.
DR RefSeq; NP_001188420.1; NM_001201491.1.
DR AlphaFoldDB; Q9PVR2; -.
DR SMR; Q9PVR2; -.
DR GeneID; 100529156; -.
DR KEGG; ola:100529156; -.
DR CTD; 30350; -.
DR eggNOG; KOG0487; Eukaryota.
DR InParanoid; Q9PVR2; -.
DR OrthoDB; 728401at2759; -.
DR Proteomes; UP000001038; Unplaced.
DR Proteomes; UP000265180; Chromosome 9.
DR Proteomes; UP000265200; Chromosome 9.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR GO; GO:0006351; P:DNA-templated transcription; IEA:InterPro.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IBA:GO_Central.
DR GO; GO:0009954; P:proximal/distal pattern formation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR006711; Hox9_activation_N.
DR InterPro; IPR017112; HXA9/HXB9/HXC9.
DR PANTHER; PTHR45970; AGAP004664-PA; 1.
DR PANTHER; PTHR45970:SF4; HOMEOBOX PROTEIN HOX-D9; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF04617; Hox9_act; 1.
DR PIRSF; PIRSF037109; Homeobox_Hox9; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..271
FT /note="Homeobox protein Hox-D9"
FT /id="PRO_0000200225"
FT DNA_BIND 203..262
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 161..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..187
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 271 AA; 30810 MW; 72E0BF3546616478 CRC64;
MSRKRSKMSS SGTISNYYVD GVMAQEPEDV YAPRLIQASH TVTPRPSGAG DNADFSSCNF
APKPGVFSSS WSSVHPQGIY HPYVHHHHQP HLSATDGRYV GVRPWMEPIS NHVSFAGFHP
SNTRPYGAKP DVLPAKVPEC DTLEPEARPV PAEFSCGGAL GAEKVTKEQR RASEISSHGE
PKDEKQQLDP NNPAANWIHA RSTRKKRCPY TKYQTLELEK EFLYNMYLTR DRRFEVARIL
SLTERQVKIW FQNRRMKMKK MNREKGGKDQ L
//
