ID HXT14_YEAST Reviewed; 540 AA.
AC P42833; D6W0M7;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 2.
DT 27-MAR-2024, entry version 168.
DE RecName: Full=Hexose transporter HXT14;
GN Name=HXT14; Synonyms=HXT9; OrderedLocusNames=YNL318C; ORFNames=N0345;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=S288c / FY1676;
RX PubMed=7502583; DOI=10.1002/yea.320111109;
RA Maftahi M., Nicaud J.-M., Levesque H., Gaillardin C.;
RT "Sequencing analysis of a 24.7 kb fragment of yeast chromosome XIV
RT identifies six known genes, a new member of the hexose transporter family
RT and ten new open reading frames.";
RL Yeast 11:1077-1085(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169873;
RA Philippsen P., Kleine K., Poehlmann R., Duesterhoeft A., Hamberg K.,
RA Hegemann J.H., Obermaier B., Urrestarazu L.A., Aert R., Albermann K.,
RA Altmann R., Andre B., Baladron V., Ballesta J.P.G., Becam A.-M.,
RA Beinhauer J.D., Boskovic J., Buitrago M.J., Bussereau F., Coster F.,
RA Crouzet M., D'Angelo M., Dal Pero F., De Antoni A., del Rey F., Doignon F.,
RA Domdey H., Dubois E., Fiedler T.A., Fleig U., Floeth M., Fritz C.,
RA Gaillardin C., Garcia-Cantalejo J.M., Glansdorff N., Goffeau A.,
RA Gueldener U., Herbert C.J., Heumann K., Heuss-Neitzel D., Hilbert H.,
RA Hinni K., Iraqui Houssaini I., Jacquet M., Jimenez A., Jonniaux J.-L.,
RA Karpfinger-Hartl L., Lanfranchi G., Lepingle A., Levesque H., Lyck R.,
RA Maftahi M., Mallet L., Maurer C.T.C., Messenguy F., Mewes H.-W., Moestl D.,
RA Nasr F., Nicaud J.-M., Niedenthal R.K., Pandolfo D., Pierard A.,
RA Piravandi E., Planta R.J., Pohl T.M., Purnelle B., Rebischung C.,
RA Remacha M.A., Revuelta J.L., Rinke M., Saiz J.E., Sartorello F.,
RA Scherens B., Sen-Gupta M., Soler-Mira A., Urbanus J.H.M., Valle G.,
RA Van Dyck L., Verhasselt P., Vierendeels F., Vissers S., Voet M.,
RA Volckaert G., Wach A., Wambutt R., Wedler H., Zollner A., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its
RT evolutionary implications.";
RL Nature 387:93-98(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- FUNCTION: Probable glucose transporter.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000305}.
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DR EMBL; Z46259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Z71595; CAA96250.1; -; Genomic_DNA.
DR EMBL; BK006947; DAA10243.1; -; Genomic_DNA.
DR PIR; S63299; S63299.
DR RefSeq; NP_014081.1; NM_001183156.1.
DR AlphaFoldDB; P42833; -.
DR SMR; P42833; -.
DR BioGRID; 35521; 21.
DR DIP; DIP-8115N; -.
DR IntAct; P42833; 2.
DR MINT; P42833; -.
DR STRING; 4932.YNL318C; -.
DR TCDB; 2.A.1.1.109; the major facilitator superfamily (mfs).
DR PaxDb; 4932-YNL318C; -.
DR TopDownProteomics; P42833; -.
DR EnsemblFungi; YNL318C_mRNA; YNL318C; YNL318C.
DR GeneID; 855398; -.
DR KEGG; sce:YNL318C; -.
DR AGR; SGD:S000005262; -.
DR SGD; S000005262; HXT14.
DR VEuPathDB; FungiDB:YNL318C; -.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_001265_30_1_1; -.
DR InParanoid; P42833; -.
DR OMA; IFGWDVG; -.
DR OrthoDB; 1058279at2759; -.
DR BioCyc; YEAST:G3O-33304-MONOMER; -.
DR BioGRID-ORCS; 855398; 0 hits in 10 CRISPR screens.
DR PRO; PR:P42833; -.
DR Proteomes; UP000002311; Chromosome XIV.
DR RNAct; P42833; Protein.
DR GO; GO:0071944; C:cell periphery; HDA:SGD.
DR GO; GO:0000324; C:fungal-type vacuole; HDA:SGD.
DR GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005351; F:carbohydrate:proton symporter activity; IBA:GO_Central.
DR GO; GO:0005354; F:galactose transmembrane transporter activity; IMP:SGD.
DR GO; GO:0008643; P:carbohydrate transport; IBA:GO_Central.
DR GO; GO:0008645; P:hexose transmembrane transport; IMP:SGD.
DR CDD; cd17356; MFS_HXT; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR NCBIfam; TIGR00879; SP; 1.
DR PANTHER; PTHR48022:SF50; HEXOSE TRANSPORTER HXT14; 1.
DR PANTHER; PTHR48022; PLASTIDIC GLUCOSE TRANSPORTER 4; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Repeat; Sugar transport; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..540
FT /note="Hexose transporter HXT14"
FT /id="PRO_0000050403"
FT TOPO_DOM 1..56
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 57..76
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..119
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 120..140
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 141..146
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 168..177
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 178..198
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 199..204
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 205..225
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 226..243
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..357
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 358..374
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 375..380
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..398
FT /note="Helical; Name=8"
FT /evidence="ECO:0000255"
FT TOPO_DOM 399..405
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 406..426
FT /note="Helical; Name=9"
FT /evidence="ECO:0000255"
FT TOPO_DOM 427..440
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 441..461
FT /note="Helical; Name=10"
FT /evidence="ECO:0000255"
FT TOPO_DOM 462..478
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 479..499
FT /note="Helical; Name=11"
FT /evidence="ECO:0000255"
FT TOPO_DOM 500
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 501..521
FT /note="Helical; Name=12"
FT /evidence="ECO:0000255"
FT TOPO_DOM 522..540
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 540 AA; 60979 MW; 91A68BA27099EEF8 CRC64;
MTAQIPYQHS SGYISHFHNN ELDAGRGRDY NVTIKYLDDK EENIEGQAAK ISHNASLHIP
VLLCLVISLG GFIFGWDIGT IGGMTNMVSF QEKFGTTNII HDDETIFVST KKLTDLQIGL
IISIFNISCG VGALTLSKIG DWIGRKGGIW FALVVYCIGI TIQILSYGRW YFLTLGRAVT
GIGVGVTTVL VPMFLSENSP LKIRGSMVST YQLIVTFGIL MGNILNFICE RCYKDPTQNI
AWQLPLFLGY IWAIIIGMSL VYVPESPQYL AKIKNDVPSA KYSFARMNGI PATDSMVIEF
IDDLLENNYN NEETNNESKK QSLVKRNTFE FIMGKPKLWL RLIIGMMIMA FQQLSGINYF
FYYGTSVFKG VGIKDPYITS IILSSVNFLS TILGIYYVEK WGHKTCLLYG STNLLFYMMT
YATVGTFGRE TDFSNIVLII VTCCFIFWFA ITLGPVTFVL VSELFPLRTR AISMAICTFI
NWMFNFLISL LTPMIVSKID FKLGYIFAAC LLALIIFSWI LVPETRKKNE QEINKIFEPE
//
