ID HYPC_HELHP Reviewed; 86 AA.
AC Q7VJB9;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE RecName: Full=Hydrogenase maturation factor HypC {ECO:0000250|UniProtKB:P0AAM3};
GN Name=hypC; OrderedLocusNames=HH_0324;
OS Helicobacter hepaticus (strain ATCC 51449 / 3B1).
OC Bacteria; Campylobacterota; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=235279;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51449 / 3B1;
RX PubMed=12810954; DOI=10.1073/pnas.1332093100;
RA Suerbaum S., Josenhans C., Sterzenbach T., Drescher B., Brandt P., Bell M.,
RA Droege M., Fartmann B., Fischer H.-P., Ge Z., Hoerster A., Holland R.,
RA Klein K., Koenig J., Macko L., Mendz G.L., Nyakatura G., Schauer D.B.,
RA Shen Z., Weber J., Frosch M., Fox J.G.;
RT "The complete genome sequence of the carcinogenic bacterium Helicobacter
RT hepaticus.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7901-7906(2003).
RN [2]
RP DISRUPTION PHENOTYPE.
RC STRAIN=ATCC 51449 / 3B1;
RX PubMed=17975083; DOI=10.1099/mic.0.2007/010520-0;
RA Benoit S.L., Zbell A.L., Maier R.J.;
RT "Nickel enzyme maturation in Helicobacter hepaticus: roles of accessory
RT proteins in hydrogenase and urease activities.";
RL Microbiology 153:3748-3756(2007).
CC -!- FUNCTION: Involved in the maturation of [NiFe] hydrogenases. Involved
CC in the biosynthesis of the Fe(CN)(2)CO cofactor.
CC {ECO:0000250|UniProtKB:P0AAM3}.
CC -!- PATHWAY: Protein modification; [NiFe] hydrogenase maturation.
CC {ECO:0000250|UniProtKB:P0AAM3}.
CC -!- DISRUPTION PHENOTYPE: Strains missing this gene do not produce
CC hydrogenase; addition of Ni(2+) to cell cultures does not compensate
CC this loss of function. Interestingly higher than usual urease activity
CC was produced in this strain; this effect was increased by increasing
CC amount of Ni(2+) in cell cultures. {ECO:0000269|PubMed:17975083}.
CC -!- SIMILARITY: Belongs to the HupF/HypC family. {ECO:0000305}.
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DR EMBL; AE017125; AAP76921.1; -; Genomic_DNA.
DR RefSeq; WP_011115167.1; NC_004917.1.
DR AlphaFoldDB; Q7VJB9; -.
DR SMR; Q7VJB9; -.
DR STRING; 235279.HH_0324; -.
DR GeneID; 82134932; -.
DR KEGG; hhe:HH_0324; -.
DR eggNOG; COG0298; Bacteria.
DR HOGENOM; CLU_159381_2_0_7; -.
DR OrthoDB; 9806017at2; -.
DR UniPathway; UPA00335; -.
DR Proteomes; UP000002495; Chromosome.
DR Gene3D; 2.30.30.140; -; 1.
DR InterPro; IPR019812; Hydgase_assmbl_chp_CS.
DR InterPro; IPR001109; Hydrogenase_HupF/HypC.
DR NCBIfam; TIGR00074; hypC_hupF; 1.
DR PANTHER; PTHR35177; HYDROGENASE MATURATION FACTOR HYBG; 1.
DR PANTHER; PTHR35177:SF2; HYDROGENASE MATURATION FACTOR HYBG; 1.
DR Pfam; PF01455; HupF_HypC; 1.
DR PRINTS; PR00445; HUPFHYPC.
DR SUPFAM; SSF159127; HupF/HypC-like; 1.
DR PROSITE; PS01097; HUPF_HYPC; 1.
PE 3: Inferred from homology;
KW Reference proteome.
FT CHAIN 1..86
FT /note="Hydrogenase maturation factor HypC"
FT /id="PRO_0000372091"
SQ SEQUENCE 86 AA; 9765 MW; BBED713560D768CA CRC64;
MCLAIPSKVV EIKDNNMAVV DTLGVSREAS LDLLNESVNI GDWVLLHIGY VMSKIDEESA
RESLRLYEQI LQSMQEEENE RIEANK
//
