ID   I0H948_ACTM4            Unreviewed;       641 AA.
AC   I0H948;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   27-MAR-2024, entry version 47.
DE   RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
GN   OrderedLocusNames=AMIS_43150 {ECO:0000313|EMBL:BAL89535.1};
OS   Actinoplanes missouriensis (strain ATCC 14538 / DSM 43046 / CBS 188.64 /
OS   JCM 3121 / NBRC 102363 / NCIMB 12654 / NRRL B-3342 / UNCC 431).
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Actinoplanes.
OX   NCBI_TaxID=512565 {ECO:0000313|EMBL:BAL89535.1, ECO:0000313|Proteomes:UP000007882};
RN   [1] {ECO:0000313|EMBL:BAL89535.1, ECO:0000313|Proteomes:UP000007882}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14538 / DSM 43046 / CBS 188.64 / JCM 3121 / NBRC 102363 /
RC   NCIMB 12654 / NRRL B-3342 / UNCC 431
RC   {ECO:0000313|Proteomes:UP000007882};
RA   Ohnishi Y., Ishikawa J., Sekine M., Hosoyama A., Harada T., Narita H.,
RA   Hata T., Konno Y., Tutikane K., Fujita N., Horinouchi S., Hayakawa M.;
RT   "Complete genome sequence of Actinoplanes missouriensis 431 (= NBRC
RT   102363).";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; AP012319; BAL89535.1; -; Genomic_DNA.
DR   RefSeq; WP_014444429.1; NC_017093.1.
DR   AlphaFoldDB; I0H948; -.
DR   STRING; 512565.AMIS_43150; -.
DR   KEGG; ams:AMIS_43150; -.
DR   PATRIC; fig|512565.3.peg.4299; -.
DR   eggNOG; COG2304; Bacteria.
DR   HOGENOM; CLU_426789_0_0_11; -.
DR   OrthoDB; 491589at2; -.
DR   Proteomes; UP000007882; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd00198; vWFA; 1.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   Pfam; PF13531; SBP_bac_11; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007882};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        40..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        84..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          441..637
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
SQ   SEQUENCE   641 AA;  67453 MW;  C2294A5397142121 CRC64;
     MPDETGESEK GHRLHTIVAG LIAMVIVGVS LFALERANNI YVLAVSATVL AAVTLWTFAI
     LASISKAVEA GFSLPQRLPR RARLILIGGT VIAIVTVSGV VFEATRPDIC PQALELRILA
     SPDGAQATRE LAHEYTRATA LGNDGCPAVY PYVYAAGTSV ASGALARMWT GAKQDRPLEH
     LGPRPDIWLP DSMLDVRQVE EIVVKGTLPS PLAGVTSIGS SPIVLAGTRV TGVPESTDNT
     LPKLVSAVLD RPGFAPALAA ADPQSSTAGL LAADVYLRDA EGEMVGADVA RRRTQIVADS
     APPAGSETRL LCAYLREGRL PETALTSLRT WKRYLKGKPL GTPGCTTPRT PPSNLPEPVV
     LASAPALDLP FVQFTWTSTR HRAEVERFRA WLLGEDADPY LREAGLGEPH SACADLALNA
     CLPRDPKKTL SLYERAKRPG RVLLAVDTSG SMADPAGPGK ATRFSVAARG VGEALGQIGA
     RDEFGLWSFP TVKGRTSPEL VSIGPGTPQH RTTVVDTLRT VKPAGATPLY TTVVAGMREL
     AEPGGGDRIR AMVVLTDGEN TSGDLSLERT VAEVKRAAGA DVRLYVIATG EASCDDGGGG
     AADPGPLYQL ARAGRGACLP AGAQELPETM TRLFETLWSG K
//