ID   I0HE05_ACTM4            Unreviewed;       731 AA.
AC   I0HE05;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN   OrderedLocusNames=AMIS_60220 {ECO:0000313|EMBL:BAL91242.1};
OS   Actinoplanes missouriensis (strain ATCC 14538 / DSM 43046 / CBS 188.64 /
OS   JCM 3121 / NBRC 102363 / NCIMB 12654 / NRRL B-3342 / UNCC 431).
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Actinoplanes.
OX   NCBI_TaxID=512565 {ECO:0000313|EMBL:BAL91242.1, ECO:0000313|Proteomes:UP000007882};
RN   [1] {ECO:0000313|EMBL:BAL91242.1, ECO:0000313|Proteomes:UP000007882}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14538 / DSM 43046 / CBS 188.64 / JCM 3121 / NBRC 102363 /
RC   NCIMB 12654 / NRRL B-3342 / UNCC 431
RC   {ECO:0000313|Proteomes:UP000007882};
RA   Ohnishi Y., Ishikawa J., Sekine M., Hosoyama A., Harada T., Narita H.,
RA   Hata T., Konno Y., Tutikane K., Fujita N., Horinouchi S., Hayakawa M.;
RT   "Complete genome sequence of Actinoplanes missouriensis 431 (= NBRC
RT   102363).";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   EMBL; AP012319; BAL91242.1; -; Genomic_DNA.
DR   AlphaFoldDB; I0HE05; -.
DR   STRING; 512565.AMIS_60220; -.
DR   KEGG; ams:AMIS_60220; -.
DR   PATRIC; fig|512565.3.peg.6017; -.
DR   eggNOG; COG0210; Bacteria.
DR   eggNOG; COG2026; Bacteria.
DR   HOGENOM; CLU_023846_0_0_11; -.
DR   Proteomes; UP000007882; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000007882}.
FT   DOMAIN          235..525
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   BINDING         256..263
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   731 AA;  81056 MW;  CF536A8E71533C4C CRC64;
     MRTEATLRIM NRAHKEMTAL PRQEQGAVYE FMNRFRANHR DPVLHVRAAG ADSDLLAARV
     DGAYRALLLP VGECDYLLVA VKHRDQVADT LTRQAFRVNR VSGGIEVIDL AQAAQTSAPR
     SPRRPLFGAY TDEQLLGLGI AELLLPQVRT LSSEEELTEL VGRAPQLTAD VLVALAAGNS
     YAEVYAQITE PVAAEEPVDP DDFATAVNSP ATQVFSDDEA LQAVLVKDFA QWQVFLHPTQ
     RKLAEKPTTG PTRVGGGPGT GKTIVALHRV AHLVKQLPPG KDKPILLTTF NRNLAADLRT
     RLVALGGQEL TARVDIVNID KLAGRVVSEA KVGTGRRIVD DNRVPDLWQT FLLEVGEKGW
     DADFLYAEWT QVILGQVLNS RSDYFRARRP NRGRSLTRGE RDQVWQLTEQ FTNWLDGQGM
     WTWRQVAERA ARLEMDRAAR AVAAAEESSG SLLRHRYRHV VVDEAQDLSA AHWKMLRAMV
     PTTGDDMFLA GDTHQRIYDN HVTLGSLGIN IRGRSSRLTL SYRTTRQILA AALEIMSGEV
     YDDLNGGEEN LAGYRSLLRG EQPVFRAAAT WNQELDLIFE QVKGWGSPAD GSVAICVPTR
     ELAAAVAARL QQDGVPVTEI GPDGPKGAGG VHIGTMHRFK GLEYQRMIIA GVSHDLIPRG
     MIDRYETVDP KRYQRERQRD RSLLFVAATR ARDELAVFWH GTPSPFLTAR LTQQRLSEDP
     AARLGLDRQA L
//