GenomeNet

Database: UniProt
Entry: I0HEF0_ACTM4
LinkDB: I0HEF0_ACTM4
Original site: I0HEF0_ACTM4 
ID   I0HEF0_ACTM4            Unreviewed;       318 AA.
AC   I0HEF0;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   24-JAN-2024, entry version 51.
DE   RecName: Full=Histidine N-alpha-methyltransferase {ECO:0000256|HAMAP-Rule:MF_02037};
DE            EC=2.1.1.44 {ECO:0000256|HAMAP-Rule:MF_02037};
DE   AltName: Full=Histidine trimethyltransferase {ECO:0000256|HAMAP-Rule:MF_02037};
GN   Name=egtD {ECO:0000256|HAMAP-Rule:MF_02037};
GN   OrderedLocusNames=AMIS_61670 {ECO:0000313|EMBL:BAL91387.1};
OS   Actinoplanes missouriensis (strain ATCC 14538 / DSM 43046 / CBS 188.64 /
OS   JCM 3121 / NBRC 102363 / NCIMB 12654 / NRRL B-3342 / UNCC 431).
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Actinoplanes.
OX   NCBI_TaxID=512565 {ECO:0000313|EMBL:BAL91387.1, ECO:0000313|Proteomes:UP000007882};
RN   [1] {ECO:0000313|EMBL:BAL91387.1, ECO:0000313|Proteomes:UP000007882}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14538 / DSM 43046 / CBS 188.64 / JCM 3121 / NBRC 102363 /
RC   NCIMB 12654 / NRRL B-3342 / UNCC 431
RC   {ECO:0000313|Proteomes:UP000007882};
RA   Ohnishi Y., Ishikawa J., Sekine M., Hosoyama A., Harada T., Narita H.,
RA   Hata T., Konno Y., Tutikane K., Fujita N., Horinouchi S., Hayakawa M.;
RT   "Complete genome sequence of Actinoplanes missouriensis 431 (= NBRC
RT   102363).";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the SAM-dependent triple methylation of the alpha-
CC       amino group of histidine to form hercynine, a step in the biosynthesis
CC       pathway of ergothioneine. {ECO:0000256|HAMAP-Rule:MF_02037}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-histidine + 3 S-adenosyl-L-methionine = 3 H(+) + hercynine +
CC         3 S-adenosyl-L-homocysteine; Xref=Rhea:RHEA:38471, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:15781, ChEBI:CHEBI:57595, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789; EC=2.1.1.44; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_02037};
CC   -!- PATHWAY: Amino-acid biosynthesis; ergothioneine biosynthesis.
CC       {ECO:0000256|HAMAP-Rule:MF_02037}.
CC   -!- SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_02037}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. EgtD family.
CC       {ECO:0000256|HAMAP-Rule:MF_02037}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP012319; BAL91387.1; -; Genomic_DNA.
DR   RefSeq; WP_014446274.1; NC_017093.1.
DR   AlphaFoldDB; I0HEF0; -.
DR   STRING; 512565.AMIS_61670; -.
DR   KEGG; ams:AMIS_61670; -.
DR   PATRIC; fig|512565.3.peg.6162; -.
DR   eggNOG; COG4301; Bacteria.
DR   HOGENOM; CLU_049766_1_0_11; -.
DR   OMA; RVEMHLV; -.
DR   OrthoDB; 5289726at2; -.
DR   UniPathway; UPA01014; -.
DR   Proteomes; UP000007882; Chromosome.
DR   GO; GO:0030745; F:dimethylhistidine N-methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008276; F:protein methyltransferase activity; IEA:InterPro.
DR   GO; GO:0052699; P:ergothioneine biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   HAMAP; MF_02037; EgtD; 1.
DR   InterPro; IPR035094; EgtD.
DR   InterPro; IPR032888; EgtD_Actinobacteria.
DR   InterPro; IPR019257; MeTrfase_dom.
DR   InterPro; IPR017804; MeTrfase_EgtD-like.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   NCBIfam; TIGR03438; egtD_ergothio; 1.
DR   PANTHER; PTHR43397; ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1; 1.
DR   PANTHER; PTHR43397:SF1; ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1; 1.
DR   Pfam; PF10017; Methyltransf_33; 1.
DR   PIRSF; PIRSF018005; UCP018005; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|HAMAP-
KW   Rule:MF_02037}; Reference proteome {ECO:0000313|Proteomes:UP000007882};
KW   S-adenosyl-L-methionine {ECO:0000256|HAMAP-Rule:MF_02037};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW   Rule:MF_02037}.
FT   DOMAIN          15..316
FT                   /note="Histidine-specific methyltransferase SAM-dependent"
FT                   /evidence="ECO:0000259|Pfam:PF10017"
FT   BINDING         52
FT                   /ligand="L-histidine"
FT                   /ligand_id="ChEBI:CHEBI:57595"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02037"
FT   BINDING         82
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02037"
FT   BINDING         88
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02037"
FT   BINDING         109
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02037"
FT   BINDING         137..138
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02037"
FT   BINDING         162
FT                   /ligand="L-histidine"
FT                   /ligand_id="ChEBI:CHEBI:57595"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02037"
FT   BINDING         202
FT                   /ligand="L-histidine"
FT                   /ligand_id="ChEBI:CHEBI:57595"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02037"
FT   BINDING         278..280
FT                   /ligand="L-histidine"
FT                   /ligand_id="ChEBI:CHEBI:57595"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_02037"
SQ   SEQUENCE   318 AA;  34735 MW;  8584E970DEF06AD0 CRC64;
     MINLIDDDDI ARALRSDVRT GLTASPKSLP PKWFYDARGS ELFEEITRLP EYYPTRTERA
     VLTEAAPAIA RITEAKTLVE LGSGSSEKTR LLLDAMLGRG TLGSFVPLDV SSSFLAESVA
     RLQADYPGLT VTGVAGDFAR HLGHLPDGDN RVIAFLGGTI GNLAPAERAA FLASVRQTLH
     PGEWLLLGAD LVKDPAVLVP AYDDAAGVTA AFNRNVLQVV NRELGADFDP AAFAHVALWD
     PDREWIEMRL RAGAAQRVRI PALDLTVEFA AGEEMRTEIS AKFRRAGLRD ELGVAGFELS
     HWWTDPREWF GVMLAQAR
//
DBGET integrated database retrieval system