ID I0HNJ2_RUBGI Unreviewed; 723 AA.
AC I0HNJ2;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=methylmalonyl-CoA mutase {ECO:0000256|ARBA:ARBA00012398};
DE EC=5.4.99.2 {ECO:0000256|ARBA:ARBA00012398};
GN OrderedLocusNames=RGE_12380 {ECO:0000313|EMBL:BAL94579.1};
OS Rubrivivax gelatinosus (strain NBRC 100245 / IL144).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sphaerotilaceae; Rubrivivax.
OX NCBI_TaxID=983917 {ECO:0000313|EMBL:BAL94579.1, ECO:0000313|Proteomes:UP000007883};
RN [1] {ECO:0000313|EMBL:BAL94579.1, ECO:0000313|Proteomes:UP000007883}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 100245 / IL144 {ECO:0000313|Proteomes:UP000007883};
RX PubMed=22689232; DOI=10.1128/JB.00511-12;
RA Nagashima S., Kamimura A., Shimizu T., Nakamura-isaki S., Aono E.,
RA Sakamoto K., Ichikawa N., Nakazawa H., Sekine M., Yamazaki S., Fujita N.,
RA Shimada K., Hanada S., Nagashima K.V.P.;
RT "Complete genome sequence of phototrophic betaproteobacterium Rubrivivax
RT gelatinosus IL144.";
RL J. Bacteriol. 194:3541-3542(2012).
CC -!- COFACTOR:
CC Name=adenosylcob(III)alamin; Xref=ChEBI:CHEBI:18408;
CC Evidence={ECO:0000256|ARBA:ARBA00001922};
CC -!- SIMILARITY: Belongs to the methylmalonyl-CoA mutase family.
CC {ECO:0000256|ARBA:ARBA00008465}.
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DR EMBL; AP012320; BAL94579.1; -; Genomic_DNA.
DR RefSeq; WP_014427450.1; NC_017075.1.
DR AlphaFoldDB; I0HNJ2; -.
DR STRING; 983917.RGE_12380; -.
DR KEGG; rge:RGE_12380; -.
DR PATRIC; fig|983917.3.peg.1205; -.
DR eggNOG; COG1884; Bacteria.
DR eggNOG; COG2185; Bacteria.
DR HOGENOM; CLU_009523_3_1_4; -.
DR Proteomes; UP000007883; Chromosome.
DR GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004494; F:methylmalonyl-CoA mutase activity; IEA:UniProtKB-EC.
DR CDD; cd02071; MM_CoA_mut_B12_BD; 1.
DR CDD; cd03679; MM_CoA_mutase_alpha_like; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.20.20.240; Methylmalonyl-CoA mutase; 1.
DR InterPro; IPR006159; Acid_CoA_mut_C.
DR InterPro; IPR016176; Cbl-dep_enz_cat.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR006099; MeMalonylCoA_mutase_a/b_cat.
DR InterPro; IPR006098; MMCoA_mutase_a_cat.
DR NCBIfam; TIGR00640; acid_CoA_mut_C; 1.
DR NCBIfam; TIGR00641; acid_CoA_mut_N; 1.
DR PANTHER; PTHR48101:SF4; METHYLMALONYL-COA MUTASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR48101; METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF01642; MM_CoA_mutase; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF51703; Cobalamin (vitamin B12)-dependent enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS00544; METMALONYL_COA_MUTASE; 1.
PE 3: Inferred from homology;
KW Cobalamin {ECO:0000256|ARBA:ARBA00022628};
KW Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:BAL94579.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007883}.
FT DOMAIN 593..723
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
SQ SEQUENCE 723 AA; 78315 MW; 35A0EA165B069549 CRC64;
MSNSPDPLKS GEFAPSSLEQ WQKAAAKSAP GGDVEALNWQ TPEGLTVKPL YTAADTAELP
YADTLPGFEP FIRGPQATMY AVRPWTIRQY AGFSTAEESN AFYRKALAAG GQGVSVAFDL
ATHRGYDSDH PRVTGDVGKA GVAIDSVEDM KILFDAIPLD KVSVSMTMNG AVLPVLAGYV
VAAEEQGVAQ ELLSGTIQND ILKEFMVRNT YIYPPEPSMR IVADIIEYTA RHMPKFNSIS
ISGYHMQEAG ANQALELAFT LADGKEYVKT AIARGLDVDE FAGRLSFFWA IGMNFYLEIA
KMRAARLLWC RIMKGFNAKK PKSLMLRTHC QTSGWSLTEQ DPYNNIVRTT VEAMAAVFGG
TQSLHTNSFD EAIALPTEFS SRIARNTQLI IQEETHITKV VDPWAGSYLM EKLTQDMADK
AWAIIEEVEA MGGMTRAVDS GWAKLKIEAS AAEKQARIDS GQDVIVGVNK YRNSKQDKVE
ILEVDNVKVR DAQIARLAQV RAARDGAKVQ AALEALTAAA HSGEGNLLGL AIDAMRVRAT
VGEVSDALEK IFGRHRADIQ KVTGVYAAAY DSAEGWDKLK AEIDEFAEQQ GRRPRVMIAK
LGQDGHDRGA KVVATAFADL GFDVDIGALF QTPEECARQA IENDVHAVGV STLAAGHKTL
VPAIIKALKD QGADDIVVFA GGVIPQQDYD FLFEAGVKGI YGPGTPVPAS AKDVLEQIKK
AVG
//
