GenomeNet

Database: UniProt
Entry: I0IDY7_PHYMF
LinkDB: I0IDY7_PHYMF
Original site: I0IDY7_PHYMF 
ID   I0IDY7_PHYMF            Unreviewed;       216 AA.
AC   I0IDY7;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   24-JAN-2024, entry version 48.
DE   RecName: Full=Ribonuclease H {ECO:0000256|PIRNR:PIRNR037839};
DE            EC=3.1.26.4 {ECO:0000256|PIRNR:PIRNR037839};
GN   Name=rnhA {ECO:0000313|EMBL:BAM03475.1};
GN   OrderedLocusNames=PSMK_13160 {ECO:0000313|EMBL:BAM03475.1};
OS   Phycisphaera mikurensis (strain NBRC 102666 / KCTC 22515 / FYK2301M01).
OC   Bacteria; Planctomycetota; Phycisphaerae; Phycisphaerales;
OC   Phycisphaeraceae; Phycisphaera.
OX   NCBI_TaxID=1142394 {ECO:0000313|EMBL:BAM03475.1, ECO:0000313|Proteomes:UP000007881};
RN   [1] {ECO:0000313|EMBL:BAM03475.1, ECO:0000313|Proteomes:UP000007881}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NBRC 102666 / KCTC 22515 / FYK2301M01
RC   {ECO:0000313|Proteomes:UP000007881};
RA   Ankai A., Hosoyama A., Terui Y., Sekine M., Fukai R., Kato Y., Nakamura S.,
RA   Yamada-Narita S., Kawakoshi A., Fukunaga Y., Yamazaki S., Fujita N.;
RT   "Complete genome sequence of Phycisphaera mikurensis NBRC 102666.";
RL   Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Endonuclease that specifically degrades the RNA of RNA-DNA
CC       hybrids. {ECO:0000256|PIRNR:PIRNR037839}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.4;
CC         Evidence={ECO:0000256|PIRNR:PIRNR037839};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR037839-1};
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR037839-1};
CC       Note=Binds 2 metal ions per subunit. Manganese or magnesium.
CC       {ECO:0000256|PIRSR:PIRSR037839-1};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037839}.
CC   -!- SIMILARITY: Belongs to the RNase H family.
CC       {ECO:0000256|PIRNR:PIRNR037839}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AP012338; BAM03475.1; -; Genomic_DNA.
DR   RefSeq; WP_014436694.1; NC_017080.1.
DR   AlphaFoldDB; I0IDY7; -.
DR   STRING; 1142394.PSMK_13160; -.
DR   GeneID; 80847734; -.
DR   KEGG; phm:PSMK_13160; -.
DR   eggNOG; COG3341; Bacteria.
DR   HOGENOM; CLU_080985_1_0_0; -.
DR   OrthoDB; 9811552at2; -.
DR   Proteomes; UP000007881; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   Gene3D; 3.40.970.10; Ribonuclease H1, N-terminal domain; 1.
DR   InterPro; IPR009027; Ribosomal_bL9/RNase_H1_N.
DR   InterPro; IPR011320; RNase_H1_N.
DR   InterPro; IPR037056; RNase_H1_N_sf.
DR   InterPro; IPR017290; RNase_H_bac.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF01693; Cauli_VI; 1.
DR   PIRSF; PIRSF037839; Ribonuclease_H; 1.
DR   SUPFAM; SSF55658; L9 N-domain-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR037839};
KW   Endonuclease {ECO:0000256|PIRNR:PIRNR037839};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR037839, ECO:0000313|EMBL:BAM03475.1};
KW   Magnesium {ECO:0000256|PIRNR:PIRNR037839, ECO:0000256|PIRSR:PIRSR037839-1};
KW   Manganese {ECO:0000256|PIRSR:PIRSR037839-1};
KW   Metal-binding {ECO:0000256|PIRNR:PIRNR037839,
KW   ECO:0000256|PIRSR:PIRSR037839-1}; Nuclease {ECO:0000256|PIRNR:PIRNR037839};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007881}.
FT   DOMAIN          5..48
FT                   /note="Ribonuclease H1 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01693"
FT   REGION          52..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         89
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037839-1"
FT   BINDING         127
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037839-1"
FT   BINDING         148
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037839-1"
FT   BINDING         211
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037839-1"
SQ   SEQUENCE   216 AA;  22792 MW;  82558D1C5265A2C6 CRC64;
     MAKKKAYVVW SGRETGVFDA WAPVLAATRG FPGARQNGYA TRAQAEAAFA AGDPDAGGAA
     PRTAAESAGL ASRSAAPGGR PTGPATCVDA ACDTTRWVME YRGVDLQTGE VLFAEGPFTG
     ANANFGEFLA IVDALRRPGG EERTLYSDSL TARAWVRKRA LNSAFLRDGK AGSRVAARLE
     DALAWLKSQP SGAKPDIRVW DTRAWGEIPA DFGRKG
//
DBGET integrated database retrieval system