ID I0INQ5_LEPFC Unreviewed; 751 AA.
AC I0INQ5;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE SubName: Full=GTP pyrophosphokinase {ECO:0000313|EMBL:BAM06904.1};
GN OrderedLocusNames=LFE_1219 {ECO:0000313|EMBL:BAM06904.1};
OS Leptospirillum ferrooxidans (strain C2-3).
OC Bacteria; Nitrospirota; Nitrospiria; Nitrospirales; Nitrospiraceae;
OC Leptospirillum.
OX NCBI_TaxID=1162668 {ECO:0000313|EMBL:BAM06904.1, ECO:0000313|Proteomes:UP000007382};
RN [1] {ECO:0000313|EMBL:BAM06904.1, ECO:0000313|Proteomes:UP000007382}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C2-3 {ECO:0000313|EMBL:BAM06904.1,
RC ECO:0000313|Proteomes:UP000007382};
RX PubMed=22815442; DOI=10.1128/JB.00696-12;
RA Fujimura R., Sato Y., Nishizawa T., Oshima K., Kim S.-W., Hattori M.,
RA Kamijo T., Ohta H.;
RT "Complete Genome Sequence of Leptospirillum ferrooxidans Strain C2-3,
RT Isolated from a Fresh Volcanic Ash Deposit on the Island of Miyake,
RT Japan.";
RL J. Bacteriol. 194:4122-4123(2012).
RN [2] {ECO:0000313|Proteomes:UP000007382}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C2-3 {ECO:0000313|Proteomes:UP000007382};
RA Fujimura R., Sato Y., Nishizawa T., Nanba K., Oshima K., Hattori M.,
RA Kamijo T., Ohta H.;
RT "The complete genome sequence of the pioneer microbe on fresh volcanic
RT deposit, Leptospirillum ferrooxidans strain C2-3.";
RL Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- PATHWAY: Purine metabolism. {ECO:0000256|ARBA:ARBA00025704}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
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DR EMBL; AP012342; BAM06904.1; -; Genomic_DNA.
DR AlphaFoldDB; I0INQ5; -.
DR STRING; 1162668.LFE_1219; -.
DR KEGG; lfc:LFE_1219; -.
DR PATRIC; fig|1162668.3.peg.1417; -.
DR eggNOG; COG0317; Bacteria.
DR HOGENOM; CLU_012300_3_0_0; -.
DR OMA; DWISSPK; -.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000007382; Chromosome.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; GTP PYROPHOSPHOKINASE; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:BAM06904.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000007382};
KW Transferase {ECO:0000313|EMBL:BAM06904.1}.
FT DOMAIN 68..168
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 411..472
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 665..739
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
SQ SEQUENCE 751 AA; 85215 MW; 030E5EECC39E4B03 CRC64;
MNNHDVSDLK ETTVIPISSI VHTVTIDQLI EETSKYNLPE ESQAKIRQAY ELSAKAHEGQ
FRRSGESYVE HPLNVAWILA SMKVDATCLI TALLHDTLED TTLSSEQIES LFGSKVVSLI
DGVTKIGKFH FQATKAEKQA ENFRKMLLSM SEDIRVILVK LADRLHNMRT ISSLNIDRQR
AIAQETLEIY APLANRLGIG WIKSELEDLS FSVQDRETYL DLKVKVSNRR RERKNYISTI
VKTVQEALIA NNLQGEVQGR YKHIYSIYRK MTIQEIPFEE IYDLMGIRII TDTKLNCYAI
LGLLHSLWKP MAGRIKDFIA VPKSNMYQSL HTTVIGSEGI PVEFQIRTEE MHRVAEEGIA
AHWNYKENAD GSPAEGERKV VAWLRQLVEW QKELPDNREF MDSVKVNLFP DEVYVFTPKG
QVKEMIKGST AIDFAYSIHT ELGHHCMGAR INGRWSPIKT ELQSGDIVEI ISSPSQSPSK
DWLRFVATPR ARARVRHWLK EEEDRQSAEI GRKSLENEFR KARLNLSDYL KSPYLEVILS
YSDQPAPTLE NVYSRIGFGQ LSPNVVLRKL VPVTQETPEQ ELPHESFPVS NHPVVVRGGG
KDLLISLARC CSPVPGEEII GYISRGRGVV IHSRDCPNLV HLSIQKERLI QSTWDNDPNN
LFEVQIRVLM EDKPGMLAGV SAAISEKGAN INHAEVKQDR HKMAVIEIAL GVKNTSDLES
IMEAIRRVKG VISVQRLKRM TGENSRRSEP A
//