ID I0JLH8_HALH3 Unreviewed; 497 AA.
AC I0JLH8;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE SubName: Full=Nucleobase/cation symporter-1 family protein (Probable substrate cytosine/purines, uracil, thiamine,allantoin) {ECO:0000313|EMBL:CCG44998.1};
GN OrderedLocusNames=HBHAL_2648 {ECO:0000313|EMBL:CCG44998.1};
OS Halobacillus halophilus (strain ATCC 35676 / DSM 2266 / JCM 20832 / KCTC
OS 3685 / LMG 17431 / NBRC 102448 / NCIMB 2269) (Sporosarcina halophila).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Halobacillus.
OX NCBI_TaxID=866895 {ECO:0000313|EMBL:CCG44998.1, ECO:0000313|Proteomes:UP000007397};
RN [1] {ECO:0000313|EMBL:CCG44998.1, ECO:0000313|Proteomes:UP000007397}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35676 / DSM 2266 / JCM 20832 / KCTC 3685 / LMG 17431 /
RC NBRC 102448 / NCIMB 2269 {ECO:0000313|Proteomes:UP000007397};
RX PubMed=22583374; DOI=10.1111/j.1462-2920.2012.02770.x;
RA Saum S.H., Pfeiffer F., Palm P., Rampp M., Schuster S.C., Muller V.,
RA Oesterhelt D.;
RT "Chloride and organic osmolytes: a hybrid strategy to cope with elevated
RT salinities by the moderately halophilic, chloride-dependent bacterium
RT Halobacillus halophilus.";
RL Environ. Microbiol. 15:1619-1633(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the purine-cytosine permease (2.A.39) family.
CC {ECO:0000256|ARBA:ARBA00008974}.
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DR EMBL; HE717023; CCG44998.1; -; Genomic_DNA.
DR RefSeq; WP_014642892.1; NC_017668.1.
DR AlphaFoldDB; I0JLH8; -.
DR STRING; 866895.HBHAL_2648; -.
DR KEGG; hhd:HBHAL_2648; -.
DR PATRIC; fig|866895.3.peg.1666; -.
DR eggNOG; COG1953; Bacteria.
DR HOGENOM; CLU_021555_0_0_9; -.
DR Proteomes; UP000007397; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd10323; SLC-NCS1sbd; 1.
DR Gene3D; 1.10.4160.10; Hydantoin permease; 1.
DR InterPro; IPR001248; Pur-cyt_permease.
DR InterPro; IPR045225; Uracil/uridine/allantoin_perm.
DR PANTHER; PTHR30618; NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER; 1.
DR PANTHER; PTHR30618:SF0; PURINE-URACIL PERMEASE NCS1; 1.
DR Pfam; PF02133; Transp_cyt_pur; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007397};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 23..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 54..76
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 128..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..277
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 289..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 330..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 355..380
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 401..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 497 AA; 53835 MW; 21E3FE87A2C88B82 CRC64;
MDKKDNHLKS PDLMPIPHHE KKIGTLGFTF MWIGMAVVLA AFAIGGAGVQ SISLIWVVLG
TLLGTLLIGF AITLTADIGI EHGISFPVYM RAPFGTLGTH FPSVVRGLAA SMWFGINTFF
GSTAINGILN ILTGFDNWFV CYVLFALFQL FNTALGIKAV EKFADLAAPI IILIGIWMYF
NLAGEASAQN KDIWGWVESP VTGGAAFTAF VIVVVSNMGY WATLAADISS ISRFIKAPKH
ERNWVKRNKG ALVGSLVGLP LTQTFIVVLG AVSYIAVSNF DPVVALQESA SGLVLGILLL
MIVLAQWSTN VSANIVPAAT IFSNVGGPKL PFWAGVFIAG LIGTVIQPWS IFNLLIPVLL
IAAAILSVIV GIIFADYYLL RKRRMNVHDL YKSGGQYRYD GGINWAGVIS WAIGSVAAYT
FSTYSFFVGF GVGALLYYLL AKHWYFKKHP QAEIENPSDE EYLGITVGRD WNIGEGFAEE
KIGRKTGTES APAKVDV
//
