ID I0JMM9_HALH3 Unreviewed; 677 AA.
AC I0JMM9;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE RecName: Full=Flagellar biosynthesis protein FlhA {ECO:0000256|RuleBase:RU364093};
GN Name=flhA {ECO:0000256|RuleBase:RU364093,
GN ECO:0000313|EMBL:CCG45399.1};
GN OrderedLocusNames=HBHAL_3052 {ECO:0000313|EMBL:CCG45399.1};
OS Halobacillus halophilus (strain ATCC 35676 / DSM 2266 / JCM 20832 / KCTC
OS 3685 / LMG 17431 / NBRC 102448 / NCIMB 2269) (Sporosarcina halophila).
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Halobacillus.
OX NCBI_TaxID=866895 {ECO:0000313|EMBL:CCG45399.1, ECO:0000313|Proteomes:UP000007397};
RN [1] {ECO:0000313|EMBL:CCG45399.1, ECO:0000313|Proteomes:UP000007397}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35676 / DSM 2266 / JCM 20832 / KCTC 3685 / LMG 17431 /
RC NBRC 102448 / NCIMB 2269 {ECO:0000313|Proteomes:UP000007397};
RX PubMed=22583374; DOI=10.1111/j.1462-2920.2012.02770.x;
RA Saum S.H., Pfeiffer F., Palm P., Rampp M., Schuster S.C., Muller V.,
RA Oesterhelt D.;
RT "Chloride and organic osmolytes: a hybrid strategy to cope with elevated
RT salinities by the moderately halophilic, chloride-dependent bacterium
RT Halobacillus halophilus.";
RL Environ. Microbiol. 15:1619-1633(2013).
CC -!- FUNCTION: Required for formation of the rod structure of the flagellar
CC apparatus. Together with FliI and FliH, may constitute the export
CC apparatus of flagellin. {ECO:0000256|RuleBase:RU364093}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU364093};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU364093}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FHIPEP (flagella/HR/invasion proteins export
CC pore) family. {ECO:0000256|ARBA:ARBA00008835,
CC ECO:0000256|RuleBase:RU364093}.
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DR EMBL; HE717023; CCG45399.1; -; Genomic_DNA.
DR RefSeq; WP_014643291.1; NC_017668.1.
DR AlphaFoldDB; I0JMM9; -.
DR STRING; 866895.HBHAL_3052; -.
DR KEGG; hhd:HBHAL_3052; -.
DR PATRIC; fig|866895.3.peg.2072; -.
DR eggNOG; COG1298; Bacteria.
DR HOGENOM; CLU_015346_3_0_9; -.
DR Proteomes; UP000007397; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0044780; P:bacterial-type flagellum assembly; IEA:InterPro.
DR GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR Gene3D; 3.40.30.60; FHIPEP family, domain 1; 1.
DR Gene3D; 1.10.8.540; FHIPEP family, domain 3; 1.
DR Gene3D; 3.40.50.12790; FHIPEP family, domain 4; 1.
DR InterPro; IPR042194; FHIPEP_1.
DR InterPro; IPR042193; FHIPEP_3.
DR InterPro; IPR042196; FHIPEP_4.
DR InterPro; IPR025505; FHIPEP_CS.
DR InterPro; IPR006301; FlhA.
DR InterPro; IPR001712; T3SS_FHIPEP.
DR NCBIfam; TIGR01398; FlhA; 1.
DR PANTHER; PTHR30161:SF1; FLAGELLAR BIOSYNTHESIS PROTEIN FLHA-RELATED; 1.
DR PANTHER; PTHR30161; FLAGELLAR EXPORT PROTEIN, MEMBRANE FLHA SUBUNIT-RELATED; 1.
DR Pfam; PF00771; FHIPEP; 1.
DR PIRSF; PIRSF005419; FlhA; 1.
DR PRINTS; PR00949; TYPE3IMAPROT.
DR PROSITE; PS00994; FHIPEP; 1.
PE 3: Inferred from homology;
KW Bacterial flagellum biogenesis {ECO:0000256|RuleBase:RU364093};
KW Bacterial flagellum protein export {ECO:0000256|RuleBase:RU364093};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU364093};
KW Cell projection {ECO:0000313|EMBL:CCG45399.1};
KW Cilium {ECO:0000313|EMBL:CCG45399.1};
KW Flagellum {ECO:0000313|EMBL:CCG45399.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU364093};
KW Protein transport {ECO:0000256|RuleBase:RU364093};
KW Reference proteome {ECO:0000313|Proteomes:UP000007397};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU364093};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU364093}; Transport {ECO:0000256|RuleBase:RU364093}.
FT TRANSMEM 6..23
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 30..47
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 53..72
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 103..120
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 188..210
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 230..251
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
FT TRANSMEM 272..305
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU364093"
SQ SEQUENCE 677 AA; 74298 MW; DFD2EB39091C3E68 CRC64;
MSARDLSVLL GVILIIVMLV IPLPGWLLSF FILINITLAL IVILVSMNME EALQFAVFPT
LLLLLTLFRL GLNVSTTRSI LSEAEAGGVI ATFGTFVIGG NPLVGFVVFV ILVIIQFLVI
TKGAERVSEV AARFTLDAMP GKQMSIDADL NAGMINEHQA KERREKIENE SDFYGAMDGA
SKFVKGDAIA GIIIVLINIV FGLIIGMVQM GMSFSEAIDT YMRLTIGDGL VSQIPALLIS
TATGIVVTRV ASQGNLSTDV TSQLLRYPKL LYIAAGTIFL LGLTPIPFFL TTLIASVLGF
GAYWLSREVE EPVENESEEL DETESDQMKS PENVVNLISM DPIEFEFGYA LIPIADSNQG
GDLLDRIVMI RRQLAIELGI VIPVVRIRDN IQLHPNEYRL KIKGNEAARG ELLLDHYLAM
SPGDEDEELE GIETQEPAFG LPAKWVTEDL KDEAELSGYT VVDPPSVVST HITEVIKQHA
HSLLGRQETQ QLIDHLKESH PILVAEVTPE PLSVGDVQKV LAKLLRENVS VHNLPVIFET
LADFGRMTTD TDLLAEYARQ SLAAQLTRQY MKEDQSVKVI TVSGKVEKII ADNIQQTEHG
NYLALDPESQ QSIISAVAAQ VEQISLQEET AVLLCSPAVR MYIKQLLERF LPQVVVLSYN
ELEPTVEVQS VGVVNVA
//
