GenomeNet

Database: UniProt
Entry: I0JSX8_HALH3
LinkDB: I0JSX8_HALH3
Original site: I0JSX8_HALH3 
ID   I0JSX8_HALH3            Unreviewed;       350 AA.
AC   I0JSX8;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   10-APR-2019, entry version 41.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|RuleBase:RU000579};
DE            EC=1.1.1.3 {ECO:0000256|RuleBase:RU000579};
GN   Name=hom2 {ECO:0000313|EMBL:CCG47250.1};
GN   OrderedLocusNames=HBHAL_4913 {ECO:0000313|EMBL:CCG47250.1};
OS   Halobacillus halophilus (strain ATCC 35676 / DSM 2266 / JCM 20832 /
OS   NBRC 102448/ NCIMB 2269) (Sporosarcina halophila).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Halobacillus.
OX   NCBI_TaxID=866895 {ECO:0000313|EMBL:CCG47250.1, ECO:0000313|Proteomes:UP000007397};
RN   [1] {ECO:0000313|EMBL:CCG47250.1, ECO:0000313|Proteomes:UP000007397}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35676 / DSM 2266 / JCM 20832 / NBRC 102448/ NCIMB 2269
RC   {ECO:0000313|Proteomes:UP000007397};
RX   PubMed=22583374; DOI=10.1111/j.1462-2920.2012.02770.x;
RA   Saum S.H., Pfeiffer F., Palm P., Rampp M., Schuster S.C., Muller V.,
RA   Oesterhelt D.;
RT   "Chloride and organic osmolytes: a hybrid strategy to cope with
RT   elevated salinities by the moderately halophilic, chloride-dependent
RT   bacterium Halobacillus halophilus.";
RL   Environ. Microbiol. 15:1619-1633(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU004171}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   -----------------------------------------------------------------------
DR   EMBL; HE717023; CCG47250.1; -; Genomic_DNA.
DR   RefSeq; WP_014645134.1; NC_017668.1.
DR   STRING; 866895.HBHAL_4913; -.
DR   EnsemblBacteria; CCG47250; CCG47250; HBHAL_4913.
DR   KEGG; hhd:HBHAL_4913; -.
DR   PATRIC; fig|866895.3.peg.3951; -.
DR   KO; K00003; -.
DR   OrthoDB; 1464088at2; -.
DR   BioCyc; HHAL866895:G1H8W-4105-MONOMER; -.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000007397; Chromosome.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR022697; HDH_short.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF036497; HDH_short; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|RuleBase:RU000579};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007397};
KW   Isoleucine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|PIRSR:PIRSR036497-2, ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000579,
KW   ECO:0000313|EMBL:CCG47250.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007397};
KW   Threonine biosynthesis {ECO:0000256|RuleBase:RU000579}.
FT   DOMAIN        9    150       NAD_binding_3. {ECO:0000259|Pfam:
FT                                PF03447}.
FT   DOMAIN      162    339       Homoserine_dh. {ECO:0000259|Pfam:
FT                                PF00742}.
FT   NP_BIND       9     14       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   ACT_SITE    229    229       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR036497-1}.
FT   BINDING     130    130       NADP. {ECO:0000256|PIRSR:PIRSR036497-2}.
FT   BINDING     214    214       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR036497-2}.
SQ   SEQUENCE   350 AA;  37969 MW;  43728BBCDF900D16 CRC64;
     MTMKIAFIGF GGVGQSLAKI MKERQENLNT VNGLDFSIVA VADMRLGAVY HPDGLNLDLL
     FEGISEHATV ETYPEDHQTV KGWSSLETIR HSNADVIVEV TFTDVKTGEP AISHCRTAFA
     HGKSVVTTNK GPVALAYEEL VQLAEDQGVF FGFEGTVMSG TPALRMPETT LAGNQITEIK
     GILNGTTNYM ITEMEKGLSY NEALEKAQKL GYAEADPTSD VEGYDARYKV SILSSHVMRS
     PIPPYEVECE GISGLNLEKI KDAWKDGEKY RLIARVEKSS GSVKASVKPE RIPMDDPLAG
     VTGATNAIVY ECDLAGSIML TGAGAGLTET GYSLLIDLIH YHKQRTPTKI
//
DBGET integrated database retrieval system