ID I0K306_9BACT Unreviewed; 963 AA.
AC I0K306;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156};
GN ORFNames=FAES_0498 {ECO:0000313|EMBL:CCG98509.1};
OS Fibrella aestuarina BUZ 2.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Spirosomataceae;
OC Fibrella.
OX NCBI_TaxID=1166018 {ECO:0000313|EMBL:CCG98509.1, ECO:0000313|Proteomes:UP000011058};
RN [1] {ECO:0000313|EMBL:CCG98509.1, ECO:0000313|Proteomes:UP000011058}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BUZ 2T {ECO:0000313|Proteomes:UP000011058};
RX PubMed=22689241; DOI=10.1128/JB.00550-12;
RA Filippini M., Qi W., Blom J., Goesmann A., Smits T.H., Bagheri H.C.;
RT "Genome Sequence of Fibrella aestuarina BUZ 2T, a Filamentous Marine
RT Bacterium.";
RL J. Bacteriol. 194:3555-3555(2012).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000256|ARBA:ARBA00038000}.
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DR EMBL; HE796683; CCG98509.1; -; Genomic_DNA.
DR AlphaFoldDB; I0K306; -.
DR STRING; 1166018.FAES_0498; -.
DR KEGG; fae:FAES_0498; -.
DR PATRIC; fig|1166018.3.peg.506; -.
DR eggNOG; COG0178; Bacteria.
DR HOGENOM; CLU_001370_0_2_10; -.
DR Proteomes; UP000011058; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR CDD; cd03271; ABC_UvrA_II; 1.
DR Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 1.
DR Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 2.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR NCBIfam; TIGR00630; uvra; 1.
DR PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR PANTHER; PTHR43152:SF3; UVRABC SYSTEM PROTEIN A; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA excision {ECO:0000256|ARBA:ARBA00022769};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Excision nuclease {ECO:0000256|ARBA:ARBA00022881};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000011058};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 625..957
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 963 AA; 106822 MW; 32D087920DCA7FD4 CRC64;
MIQEQQTTHT EPIAAGSPLS DVQLTGYEQI DVLGAREHNL KNIDVSIPRN KLVVVTGISG
SGKSSLAFDT IYAEGQRRYM ESFSAYARSF LGDMERPDVD KINGLSPVIS IEQKTTSKNP
RSTVGTTTEI FDFLRLLYAR AGEAFSYATG RKMTRQSQDQ IVDALLDQNA GRKTVLLAPV
VRGRKGHYRE LFVQIAKMGY TKVRVDGTVQ DIVPKMQVDR YKVHDIEIVI DRLVPSADDR
FRLSQSVQTA LKQGKGAIQV LDQDNKLHYF SQNLMDPESG ISYDEPSPNS FSFNSPYGWC
PTCQGLGVVE EITEESVIPD KSLSVSRGAI APLGEYRELW FFKEVEVILK KHKLSLTTPV
SKYPPELLHV LLHGSEEETP IPSKKYPGET YYTTKFEGII NFLKKQQETG SEKIQEWLRD
FLVINTCPEC NGARLKKESL YFRIADKNIA ELASMDIAVL AAWFVGIEDR LSDRQNVIAK
EILKEIRKRI GFLVDIGLDY LTLDRSLKTL SGGEAQRIRL ATQIGTQLVG VLYIMDEPSI
GLHQRDNVKL IESLKNLRDL GNTVLVVEHD KDMMLESDYI LDIGPGAGRH GGQVVGAGTP
EEFLKNGSTT ANYLSGRTAI DVPGERRKGS GKFLQIKGAT GHNLKNVTLK LPLGRMVSIT
GVSGSGKSSL IHETLFPILN HHFYKSKREP LAFKNVEGLE FIDKVIEVDQ SPIGRTPRSN
PATYTGMFSE IRTLFAELPE AKIRGYKPGR FSFNVKGGRC EECEGAGMKK IEMEFLPDVH
VPCEVCKGKR FNRETLEVRF KGKSIADVLD MTVEQALDFF QSQPKILRKV QTLNDVGLGY
ITLGQHATTL SGGEAQRVKL AEELSKKDTG KTLYILDEPT TGLHFQDIAH LLDVLNKLAD
KGNTVLIIEH NLDVIKVSDY VIDLGPEGGS KGGQIIAEGT PEKVAKVAGS YTGKFLAMEL
AGA
//
