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Database: UniProt
Entry: I0K6N9_9BACT
LinkDB: I0K6N9_9BACT
Original site: I0K6N9_9BACT 
ID   I0K6N9_9BACT            Unreviewed;       437 AA.
AC   I0K6N9;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   08-MAY-2019, entry version 36.
DE   RecName: Full=UDP-glucose 6-dehydrogenase {ECO:0000256|PIRNR:PIRNR000124};
DE            EC=1.1.1.22 {ECO:0000256|PIRNR:PIRNR000124};
GN   ORFNames=FAES_1782 {ECO:0000313|EMBL:CCG99792.1};
OS   Fibrella aestuarina BUZ 2.
OC   Bacteria; Bacteroidetes; Cytophagia; Cytophagales; Cytophagaceae;
OC   Fibrella.
OX   NCBI_TaxID=1166018 {ECO:0000313|EMBL:CCG99792.1, ECO:0000313|Proteomes:UP000011058};
RN   [1] {ECO:0000313|EMBL:CCG99792.1, ECO:0000313|Proteomes:UP000011058}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BUZ 2 {ECO:0000313|EMBL:CCG99792.1};
RX   PubMed=22689241; DOI=10.1128/JB.00550-12;
RA   Filippini M., Qi W., Blom J., Goesmann A., Smits T.H., Bagheri H.C.;
RT   "Genome Sequence of Fibrella aestuarina BUZ 2T, a Filamentous Marine
RT   Bacterium.";
RL   J. Bacteriol. 194:3555-3555(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH +
CC         UDP-alpha-D-glucuronate; Xref=Rhea:RHEA:23596,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58052, ChEBI:CHEBI:58885;
CC         EC=1.1.1.22; Evidence={ECO:0000256|PIRNR:PIRNR000124};
CC   -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC       family. {ECO:0000256|PIRNR:PIRNR000124}.
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DR   EMBL; HE796683; CCG99792.1; -; Genomic_DNA.
DR   RefSeq; WP_015330891.1; NC_020054.1.
DR   STRING; 1166018.FAES_1782; -.
DR   EnsemblBacteria; CCG99792; CCG99792; FAES_1782.
DR   KEGG; fae:FAES_1782; -.
DR   PATRIC; fig|1166018.3.peg.3519; -.
DR   KO; K00012; -.
DR   OrthoDB; 647136at2; -.
DR   BioCyc; FAES1166018:G1365-1802-MONOMER; -.
DR   Proteomes; UP000011058; Chromosome.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0003979; F:UDP-glucose 6-dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR017476; UDP-Glc/GDP-Man.
DR   InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR   InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR   InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR   InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR   InterPro; IPR028357; UDPglc_DH_bac.
DR   Pfam; PF00984; UDPG_MGDP_dh; 1.
DR   Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR   Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR   PIRSF; PIRSF500134; UDPglc_DH_bac; 1.
DR   PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR   SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52413; SSF52413; 1.
DR   TIGRFAMs; TIGR03026; NDP-sugDHase; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011058};
KW   NAD {ECO:0000256|PIRNR:PIRNR000124, ECO:0000256|PIRSR:PIRSR500134-3};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000124,
KW   ECO:0000313|EMBL:CCG99792.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011058}.
FT   DOMAIN      315    417       UDPG_MGDP_dh_C. {ECO:0000259|SMART:
FT                                SM00984}.
FT   ACT_SITE    261    261       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR500134-1}.
FT   BINDING      30     30       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      35     35       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING      86     86       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     121    121       NAD; via amide nitrogen.
FT                                {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     153    153       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     264    264       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
FT   BINDING     329    329       NAD. {ECO:0000256|PIRSR:PIRSR500134-3}.
SQ   SEQUENCE   437 AA;  48295 MW;  50AEC3C2B1E56726 CRC64;
     MKIAVVGTGY VGLVTGTCFA ETGNQVTCVD IDERKVEKLN NRIIPIYEPG LDVLFYRNVE
     EGRLKFTTNL AEGIKGAEVI FLALPTPPGE DGSADLKYIL GVANDLGPIL EQYAVIVDKS
     TVPVGTAEKV HAGIAKNAKV DFDVVSNPEF LREGVAVEDF MKPDRVVIGT KSDKAKAVMN
     RLYAPLVRQG NPVIFMDERS AEMTKYAANA FLATKITFMN EIANLCEKVG ANVDDIRKGI
     GTDSRIGKRF LFAGIGYGGS CFPKDVQALA KTAQEYDYDF RVLKSVMDVN AGQKKRLLPV
     IKQHFGGDLK GKTIAIWGLA FKPYTDDIRE APALDNIRDL LAEGAKITAY DPEAMENVRN
     ILGNQVTFAH TSYAALDDAD ALVIMTEWPM FRTPEFEKMN LLLKNKVIFD GRNVYELDQM
     RELGYTYYSI GREAVTH
//
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