ID I0L419_9ACTN Unreviewed; 308 AA.
AC I0L419;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE SubName: Full=5'-3' exonuclease {ECO:0000313|EMBL:CCH18566.1};
DE EC=3.1.11.- {ECO:0000313|EMBL:CCH18566.1};
GN ORFNames=MILUP08_43476 {ECO:0000313|EMBL:CCH18566.1};
OS Micromonospora lupini str. Lupac 08.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=1150864 {ECO:0000313|EMBL:CCH18566.1, ECO:0000313|Proteomes:UP000003448};
RN [1] {ECO:0000313|Proteomes:UP000003448}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lupac 08 {ECO:0000313|Proteomes:UP000003448};
RX PubMed=22815450; DOI=10.1128/jb.00628-12;
RA Alonso-Vega P., Normand P., Bacigalupe R., Pujic P., Lajus A., Vallenet D.,
RA Carro L., Coll P., Trujillo M.E.;
RT "Genome Sequence of Micromonospora lupini Lupac 08, Isolated from Root
RT Nodules of Lupinus angustifolius.";
RL J. Bacteriol. 194:4135-4135(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCH18566.1}.
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DR EMBL; CAIE01000026; CCH18566.1; -; Genomic_DNA.
DR RefSeq; WP_007460042.1; NZ_HF570108.1.
DR AlphaFoldDB; I0L419; -.
DR STRING; 1150864.MILUP08_43476; -.
DR eggNOG; COG0258; Bacteria.
DR OrthoDB; 9806424at2; -.
DR Proteomes; UP000003448; Unassembled WGS sequence.
DR GO; GO:0017108; F:5'-flap endonuclease activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0033567; P:DNA replication, Okazaki fragment processing; IEA:InterPro.
DR CDD; cd09898; H3TH_53EXO; 1.
DR CDD; cd09859; PIN_53EXO; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N.
DR InterPro; IPR002421; 5-3_exonuclease.
DR InterPro; IPR036279; 5-3_exonuclease_C_sf.
DR InterPro; IPR020045; DNA_polI_H3TH.
DR InterPro; IPR038969; FEN.
DR InterPro; IPR008918; HhH2.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR PANTHER; PTHR42646:SF2; DNA-DIRECTED DNA POLYMERASE; 1.
DR PANTHER; PTHR42646; FLAP ENDONUCLEASE XNI; 1.
DR Pfam; PF01367; 5_3_exonuc; 1.
DR Pfam; PF02739; 5_3_exonuc_N; 1.
DR SMART; SM00475; 53EXOc; 1.
DR SMART; SM00279; HhH2; 1.
DR SUPFAM; SSF47807; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Exonuclease {ECO:0000313|EMBL:CCH18566.1};
KW Hydrolase {ECO:0000313|EMBL:CCH18566.1};
KW Nuclease {ECO:0000313|EMBL:CCH18566.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000003448}.
FT DOMAIN 5..274
FT /note="5'-3' exonuclease"
FT /evidence="ECO:0000259|SMART:SM00475"
SQ SEQUENCE 308 AA; 32737 MW; 722032DCD686D030 CRC64;
MAHRSPILLI DAPSLYFRAY FGIPESAART EDGQPVNAVR GFLDMLATLI RGRGADRMVC
ALDYDWRPAW RVDLLPSYKA HRVAPQGGEV VPDTLSPQVP MILEVLEAVG IPAVGATGYE
ADDVLGTLSV TQPGPVEVVS GDRDLFQLID DTRDVRLLYV GRGVAKLDDC DDAAVRARYG
VPADRYADFA ALRGDPSDGL PGVPGVGEKT AARLIERYGS IDGILAALDD SDSSFAPGLR
TKLAGARDYL AVAPTVVRVA LDVALPELPT ALPTAAADPE RLLELAGRWN LAGSARRLVD
ALAARADA
//
