ID I0LD87_9ACTN Unreviewed; 349 AA.
AC I0LD87;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Naringenin-chalcone synthase {ECO:0000313|EMBL:CCH21784.1};
DE EC=2.3.1.74 {ECO:0000313|EMBL:CCH21784.1};
GN ORFNames=MILUP08_46684 {ECO:0000313|EMBL:CCH21784.1};
OS Micromonospora lupini str. Lupac 08.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Micromonospora.
OX NCBI_TaxID=1150864 {ECO:0000313|EMBL:CCH21784.1, ECO:0000313|Proteomes:UP000003448};
RN [1] {ECO:0000313|Proteomes:UP000003448}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Lupac 08 {ECO:0000313|Proteomes:UP000003448};
RX PubMed=22815450; DOI=10.1128/jb.00628-12;
RA Alonso-Vega P., Normand P., Bacigalupe R., Pujic P., Lajus A., Vallenet D.,
RA Carro L., Coll P., Trujillo M.E.;
RT "Genome Sequence of Micromonospora lupini Lupac 08, Isolated from Root
RT Nodules of Lupinus angustifolius.";
RL J. Bacteriol. 194:4135-4135(2012).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:CCH21784.1}.
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DR EMBL; CAIE01000044; CCH21784.1; -; Genomic_DNA.
DR AlphaFoldDB; I0LD87; -.
DR STRING; 1150864.MILUP08_46684; -.
DR eggNOG; COG3424; Bacteria.
DR Proteomes; UP000003448; Unassembled WGS sequence.
DR GO; GO:0102128; F:chalcone synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0016210; F:naringenin-chalcone synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR PANTHER; PTHR11877:SF46; TYPE III POLYKETIDE SYNTHASE A; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000313|EMBL:CCH21784.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000003448};
KW Transferase {ECO:0000313|EMBL:CCH21784.1}.
FT DOMAIN 57..200
FT /note="Chalcone/stilbene synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00195"
FT DOMAIN 220..345
FT /note="Chalcone/stilbene synthase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02797"
FT ACT_SITE 140
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000451-1"
SQ SEQUENCE 349 AA; 37065 MW; 8C056070A34E404E CRC64;
MSVPVIAGLG AAQPPSASQD ELWEGFFSRH FSGTTRSLAQ RIFANSGVTR RQAAVNPLLE
DVSDWPTERR MRRYQVEALP LGKEAVGRAL TAAGLDASDI GLFIVCSCTG YATPGLDILL
ARDLGMAADT QRMFIGHMGC YAALPGLGAA SDFVTARGRP ALLLCAELTS LHIQPSTARV
DTQQIVSHAL FSDAAVAAVV VPGGRGYALR EVTSVTDTST ADHMTWDVTD AGFRMGLSPK
VPQVLSRHVR DLVDGLLARH GGVSSDVDGW AVHPGGPRIL NVVERELALP PEALAASRAT
LDEHGNCSSP TVLLILDRLS RSTPAPRRIV MLAFGPGLTL YAALLDRQD
//
