ID   I0LDU0_9ACTN            Unreviewed;      1200 AA.
AC   I0LDU0;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   SubName: Full=Adenylate/guanylate cyclase {ECO:0000313|EMBL:CCH21987.1};
GN   ORFNames=MILUP08_46772 {ECO:0000313|EMBL:CCH21987.1};
OS   Micromonospora lupini str. Lupac 08.
OC   Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC   Micromonosporaceae; Micromonospora.
OX   NCBI_TaxID=1150864 {ECO:0000313|EMBL:CCH21987.1, ECO:0000313|Proteomes:UP000003448};
RN   [1] {ECO:0000313|Proteomes:UP000003448}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lupac 08 {ECO:0000313|Proteomes:UP000003448};
RX   PubMed=22815450; DOI=10.1128/jb.00628-12;
RA   Alonso-Vega P., Normand P., Bacigalupe R., Pujic P., Lajus A., Vallenet D.,
RA   Carro L., Coll P., Trujillo M.E.;
RT   "Genome Sequence of Micromonospora lupini Lupac 08, Isolated from Root
RT   Nodules of Lupinus angustifolius.";
RL   J. Bacteriol. 194:4135-4135(2012).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:CCH21987.1}.
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DR   EMBL; CAIE01000046; CCH21987.1; -; Genomic_DNA.
DR   RefSeq; WP_007466192.1; NZ_HF570108.1.
DR   AlphaFoldDB; I0LDU0; -.
DR   STRING; 1150864.MILUP08_46772; -.
DR   eggNOG; COG0457; Bacteria.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG3899; Bacteria.
DR   OrthoDB; 5476461at2; -.
DR   Proteomes; UP000003448; Unassembled WGS sequence.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR16305:SF28; ADENYLATE CYCLASE 10; 1.
DR   PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF17874; TPR_MalT; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000003448}.
FT   DOMAIN          39..167
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   1200 AA;  125410 MW;  3AD1C4BFB273A3B4 CRC64;
     MTCPVCGTVA VPGARFCHNC GSALPAAATL PAAERRVVTV LFGDLSEFTS WSEDLDPERV
     GAVTDRVLAA LAGAVKTFGG HVDKLTGDGI MAVFGAPVAH EDDAERAVRA ALSMQRAVRR
     VLDDERGGGA PLGLRVGLNT GDVIAGIQAA IEYTVIGDTV NTAARFSDAA AVGAIYAGAR
     TAAATRHVAS WRALRPLRLK GKREPVEAYE LLGLLDAPGT RSGLGDEAPY VGRETEIGRV
     AGRLAEVIDQ GDPRVLLMTA EAGIGKSRFA AEVERLAAGY DVGAGRYAAH TGARVLSVRC
     AAFGERRRLA PLADLVRAAV GLPSDAATAL TRPAVDERLR RLGQRLARSA GETPPIATDQ
     LLALLGYAEL PVHAGPDNGE WGSAAAPPAD AEAVPNAVAD LLSGLASEAP LVIVVDDLHD
     ATPETIRALG LTLSRLTGPV LVLLLGRPEL VRTAGTLTRV ADAEVHSLPP LRGADAARLL
     TSYLGGGKLP AADADRLLAT AQGNPFYLAE LVTLLIERGA LTAERQASAD RDPGTPAGWR
     LVPGSLGSRL LSRDLAAVLA ARIDALPPDA RSVLRDAAVV GDTVPTGALE ALREQRAGRD
     GRPSAVVAVE FDRAVEELLQ RRMLHRTRAG YAFATPLMRE AAYAGVSKAE LAERHAALAR
     WAAPVDGATA VAVGGFTEEA RDDFVATHVQ RAATLADAVK LRPDAPARAV VPLGIAALGR
     AARRSLSAGE PTLAIEYAER ASELARDGIP AIDRVVHARA LLQIGRVVDA LAFAEKIAAN
     AGDDTTRASA LLLAGQAQQT LGDQGRAEAA WQEALQVAKA GGLPTLRASA MRRLGMGDFV
     AGRLSQASSR LAAAYQVSLS AQDRRGQAWS LQNLAWVTTT RGDFAGTDAV LGRAARLFAE
     LKDPYGRAWL RGTTAFARLL AGRLREACRM AQVFLPFGER VGEAWAVGTL RAVAAFATAE
     LGELAEADRE ARRAYREFAA ASDDWGRGFA LVVRAVVARG LGEPEHAADL LTDALVYAEQ
     TSHPLLTGMA GTLRGFVALD MGDHETAERA ARAVLTTVEP HNPQAPAQVA PRVLLATARL
     AAGDPATAVG LLAPVATAAA HAPSLLFSRR QTMARYASAL LAHGQREQAL DWARRAVTAP
     AEDVRSQVIA ASVLAEALAA CGHSAEARSC ADEAVRLAYA TEQRSERAAA KALQTRLTPS
//