GenomeNet

Database: UniProt
Entry: I0WK44_9FLAO
LinkDB: I0WK44_9FLAO
Original site: I0WK44_9FLAO 
ID   I0WK44_9FLAO            Unreviewed;       945 AA.
AC   I0WK44;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   24-JAN-2024, entry version 62.
DE   RecName: Full=Leucine--tRNA ligase {ECO:0000256|HAMAP-Rule:MF_00049};
DE            EC=6.1.1.4 {ECO:0000256|HAMAP-Rule:MF_00049};
DE   AltName: Full=Leucyl-tRNA synthetase {ECO:0000256|HAMAP-Rule:MF_00049};
DE            Short=LeuRS {ECO:0000256|HAMAP-Rule:MF_00049};
GN   Name=leuS {ECO:0000256|HAMAP-Rule:MF_00049,
GN   ECO:0000313|EMBL:EID76760.1};
GN   ORFNames=W5A_02015 {ECO:0000313|EMBL:EID76760.1};
OS   Imtechella halotolerans K1.
OC   Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC   Flavobacteriaceae; Imtechella.
OX   NCBI_TaxID=946077 {ECO:0000313|EMBL:EID76760.1, ECO:0000313|Proteomes:UP000005938};
RN   [1] {ECO:0000313|EMBL:EID76760.1, ECO:0000313|Proteomes:UP000005938}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K1 {ECO:0000313|EMBL:EID76760.1,
RC   ECO:0000313|Proteomes:UP000005938};
RX   PubMed=22740661; DOI=10.1128/JB.00506-12;
RA   Kumar S., Vikram S., Subramanian S., Raghava G.P., Pinnaka A.K.;
RT   "Genome Sequence of the Halotolerant Bacterium Imtechella halotolerans
RT   K1T.";
RL   J. Bacteriol. 194:3731-3731(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-
CC         tRNA(Leu); Xref=Rhea:RHEA:11688, Rhea:RHEA-COMP:9613, Rhea:RHEA-
CC         COMP:9622, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57427,
CC         ChEBI:CHEBI:78442, ChEBI:CHEBI:78494, ChEBI:CHEBI:456215; EC=6.1.1.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00001372, ECO:0000256|HAMAP-
CC         Rule:MF_00049};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00049}.
CC   -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC       {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|HAMAP-Rule:MF_00049,
CC       ECO:0000256|RuleBase:RU363035}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|HAMAP-Rule:MF_00049}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EID76760.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJJU01000002; EID76760.1; -; Genomic_DNA.
DR   RefSeq; WP_008236867.1; NZ_AJJU01000002.1.
DR   AlphaFoldDB; I0WK44; -.
DR   STRING; 946077.W5A_02015; -.
DR   PATRIC; fig|946077.3.peg.412; -.
DR   eggNOG; COG0495; Bacteria.
DR   OrthoDB; 9810365at2; -.
DR   Proteomes; UP000005938; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004823; F:leucine-tRNA ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006429; P:leucyl-tRNA aminoacylation; IEA:UniProtKB-UniRule.
DR   CDD; cd07958; Anticodon_Ia_Leu_BEm; 1.
DR   CDD; cd00812; LeuRS_core; 1.
DR   Gene3D; 3.40.50.620; HUPs; 3.
DR   Gene3D; 3.90.740.10; Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain; 1.
DR   HAMAP; MF_00049_B; Leu_tRNA_synth_B; 1.
DR   InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR   InterPro; IPR002300; aa-tRNA-synth_Ia.
DR   InterPro; IPR002302; Leu-tRNA-ligase.
DR   InterPro; IPR025709; Leu_tRNA-synth_edit.
DR   InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR   InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR   InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR   NCBIfam; TIGR00396; leuS_bact; 1.
DR   PANTHER; PTHR43740:SF2; LEUCINE--TRNA LIGASE, MITOCHONDRIAL-RELATED; 1.
DR   PANTHER; PTHR43740; LEUCYL-TRNA SYNTHETASE; 1.
DR   Pfam; PF08264; Anticodon_1; 1.
DR   Pfam; PF00133; tRNA-synt_1; 1.
DR   Pfam; PF13603; tRNA-synt_1_2; 1.
DR   Pfam; PF09334; tRNA-synt_1g; 1.
DR   PRINTS; PR00985; TRNASYNTHLEU.
DR   SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR   SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR   SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR   PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE   3: Inferred from homology;
KW   Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW   ECO:0000256|HAMAP-Rule:MF_00049};
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW   Rule:MF_00049};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00049};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|HAMAP-Rule:MF_00049};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW   Rule:MF_00049};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW   Rule:MF_00049}; Reference proteome {ECO:0000313|Proteomes:UP000005938}.
FT   DOMAIN          38..145
FT                   /note="Methionyl/Leucyl tRNA synthetase"
FT                   /evidence="ECO:0000259|Pfam:PF09334"
FT   DOMAIN          277..464
FT                   /note="Leucyl-tRNA synthetase editing"
FT                   /evidence="ECO:0000259|Pfam:PF13603"
FT   DOMAIN          713..746
FT                   /note="Aminoacyl-tRNA synthetase class Ia"
FT                   /evidence="ECO:0000259|Pfam:PF00133"
FT   DOMAIN          793..907
FT                   /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT                   anticodon-binding"
FT                   /evidence="ECO:0000259|Pfam:PF08264"
FT   MOTIF           720..724
FT                   /note="'KMSKS' region"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00049"
FT   BINDING         723
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00049"
SQ   SEQUENCE   945 AA;  108719 MW;  1E5F19DA38126992 CRC64;
     MRYDHRKIEA DWQAYWAKNK TFKADNAFDK PKYYVLDMFP YPSGAGLHVG HPLGYIASDI
     YARYKRHQGF NVLHPMGYDS FGLPAEQYAI QTGQHPAITT QTNINRYREQ LDKIGFSFDW
     EREVRTSNPE YYKYTQWIFI QLFDSWYDKR EDKAKSIETL IEEFEKNGNS LVQAACDEGT
     PAFTAQHWKE YTAEEQQKML LKYRLTYLAE TEVNWCPALG TVLANDEIIN GVSERGGHPV
     IRKKMTQWSM RISAYAQRLL DGLDTIDWSE SLKESQRNWI GRSQGAMVVF KVIPKNESRD
     SMDSIQVFTT RPDTIFGVSF MTLAPEHELV SKITTNEQRA EVEAYIEATA KRSERDRMSD
     VKTISGVFTG AYAEHPFTKQ PIPVWIGDYV LAGYGTGAVM AVPCGDDRDY AFAKHFGIEI
     LNIFDQDISK AAFTAKEGFS LVNSDFLNGL DYKEGTRLVI DKLEKLGAGT SKINYRLRDA
     VFSRQRYWGE PFPVYYVNGL PRMIEKKYLP VRLPEVEKYL PTEDGQPPLG NATVWAWDTE
     THTVVSNEYI NHTTVFPLEL NTMPGWAGSS WYWMRYMDAH NEEDFASEKA LRYWQNVDLY
     IGGSEHATGH LLYSRFWNKF LRDRGYINIE EPFKKLINQG MILGMSAFVY RTEDAKKLIS
     KNKIGNTKVF PIHVDLSVIN DITNELDIEA FKNHPLYADY KNVEFVLEDG KYIVGREVEK
     MSKSKYNVVN PDDICDEYGA DTLRLYEMFL GPLEQAKPWN TAGITGVSGF LKKLWRLYFD
     EEGFIVTKEE PSKEMYKSLH KTIKKVTEDI ESFSFNTSVS QFMICVNELS QQKCHHQAIL
     EPLAVLVSPY APHIAEALWE ALGHNESISN EPFPVCQESY LIESSKEYPV SFNGKMRFKI
     ELPLDMTAED IEKLIVADSR TIEQLQGRTP KKIIVVPGKI INIVG
//
DBGET integrated database retrieval system