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Database: UniProt
Entry: I0X6B8_9SPIO
LinkDB: I0X6B8_9SPIO
Original site: I0X6B8_9SPIO 
ID   I0X6B8_9SPIO            Unreviewed;       793 AA.
AC   I0X6B8;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   13-NOV-2019, entry version 29.
DE   RecName: Full=Ferrous iron transport protein B {ECO:0000256|RuleBase:RU362098};
GN   ORFNames=MSI_23550 {ECO:0000313|EMBL:EID84184.1};
OS   Treponema sp. JC4.
OC   Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Treponema;
OC   unclassified Treponema.
OX   NCBI_TaxID=1124982 {ECO:0000313|EMBL:EID84184.1, ECO:0000313|Proteomes:UP000002967};
RN   [1] {ECO:0000313|EMBL:EID84184.1, ECO:0000313|Proteomes:UP000002967}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JC4 {ECO:0000313|EMBL:EID84184.1,
RC   ECO:0000313|Proteomes:UP000002967};
RX   PubMed=22815447; DOI=10.1128/JB.00754-12;
RA   Rosewarne C.P., Cheung J.L., Smith W.J., Evans P.N., Tomkins N.W.,
RA   Denman S.E., O Cuiv P., Morrison M.;
RT   "Draft genome sequence of Treponema sp. strain JC4, a novel spirochete
RT   isolated from the bovine rumen.";
RL   J. Bacteriol. 194:4130-4130(2012).
CC   -!- FUNCTION: Probable transporter of a GTP-driven Fe(2+) uptake
CC       system. {ECO:0000256|RuleBase:RU362098}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000256|RuleBase:RU362098}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-
CC       like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.
CC       {ECO:0000256|RuleBase:RU362098}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EID84184.1}.
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DR   EMBL; AJGU01000043; EID84184.1; -; Genomic_DNA.
DR   RefSeq; WP_009107224.1; NZ_AJGU01000043.1.
DR   STRING; 1124982.MSI_23550; -.
DR   EnsemblBacteria; EID84184; EID84184; MSI_23550.
DR   PATRIC; fig|1124982.3.peg.2299; -.
DR   BioCyc; TSP1124982:G12ON-2300-MONOMER; -.
DR   Proteomes; UP000002967; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   CDD; cd01879; FeoB; 1.
DR   InterPro; IPR003373; Fe2_transport_prot-B.
DR   InterPro; IPR011640; Fe2_transport_prot_B_C.
DR   InterPro; IPR041069; FeoB_Cyto.
DR   InterPro; IPR030389; G_FEOB_dom.
DR   InterPro; IPR011642; Gate_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF07664; FeoB_C; 1.
DR   Pfam; PF17910; FeoB_Cyto; 1.
DR   Pfam; PF02421; FeoB_N; 1.
DR   Pfam; PF07670; Gate; 2.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00437; feoB; 1.
DR   PROSITE; PS51711; G_FEOB; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002967};
KW   GTP-binding {ECO:0000256|RuleBase:RU362098};
KW   Ion transport {ECO:0000256|RuleBase:RU362098};
KW   Iron {ECO:0000256|RuleBase:RU362098};
KW   Iron transport {ECO:0000256|RuleBase:RU362098};
KW   Membrane {ECO:0000256|RuleBase:RU362098};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002967};
KW   Transmembrane {ECO:0000256|RuleBase:RU362098};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU362098};
KW   Transport {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    283    308       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    446    465       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    477    495       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    507    531       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    537    557       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    600    620       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    698    717       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    729    748       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   TRANSMEM    754    779       Helical. {ECO:0000256|RuleBase:RU362098}.
FT   DOMAIN        4    165       FeoB-type G. {ECO:0000259|PROSITE:
FT                                PS51711}.
FT   COILED      216    243       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   793 AA;  86752 MW;  2D7BFE70163238B0 CRC64;
     MAEKIIIALA GNPNCGKTTL FNALTGSNQF VGNWPGVTVE KKEGKLKKHD DVVITDLPGI
     YSLSPYTLEE VVARNYLIGE RPEAILNIVD GTNLERNLYL TTQLVELGIP VVIALNMMDL
     VKKNGDKIDV AELSRQLGCK IVEISALKGD GVMQAAEEAI KAAKNVKTVP QHTFSGAVEH
     ALAHIEEAVV HNMPEEQQRW YAIKIFERDD KVYEQLSLKK ETLSHIEEDI KAAEKELDDD
     AESIITNERY VYIAGILKSS YKKHNAGALT NSDKIDRIVT NRWLGLPIFA AIMFLVYWIS
     MVGVGAMATD WANDGLFGDG YHLFGIGTGA YEEAAEEYGD TPLILEAVEN GETTYVVEDE
     ETLELSDPIE ITDEMVEEAQ AMAEKYGEEG PAPEDYGIWV PGVPVLIGNL LESIGCAEWL
     SGLILDGIVA GCGAVLGFVP QMLVLFLLLA FLEACGYMAR IAFVLDRIFR KFGLSGKSFI
     PMLVGTGCGV PGIMASRTIE NERDRRMTIM TTTFIPCGAK VPFIAMIAGA IFSGSAWVAT
     SAYFIGMAAI IISGVMLKKT KMFAGQPAPF VMELPAYHMP TLGNVLRSMW ERGWSFIKKA
     GTIIMLSTIV VWFTSFFGWA DDGFRMLAED ELDASILAKI GGAIAWIFSP LGWGNWQATV
     ASITGLVAKE NIVGTMGILY GGGELSTYQT LAQTFTNVTG FSFLVFNLLC APCFAAIGAI
     KREMNNTKWT WFAIAYQCGF AYAIALMVNQ FGKLFTGSVN VIGTIFALAV LCGMIYMLFF
     KKYSEATKLG DLR
//
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