ID   I0XLR7_9LEPT            Unreviewed;       802 AA.
AC   I0XLR7;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   13-SEP-2023, entry version 34.
DE   SubName: Full=HDIG domain protein {ECO:0000313|EMBL:EID99824.1};
GN   ORFNames=LEP1GSC185_2591 {ECO:0000313|EMBL:EID99824.1};
OS   Leptospira licerasiae serovar Varillal str. VAR 010.
OC   Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC   Leptospira.
OX   NCBI_TaxID=1049972 {ECO:0000313|EMBL:EID99824.1, ECO:0000313|Proteomes:UP000004889};
RN   [1] {ECO:0000313|EMBL:EID99824.1, ECO:0000313|Proteomes:UP000004889}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VAR 010 {ECO:0000313|EMBL:EID99824.1};
RX   PubMed=23145189; DOI=10.1371/journal.pntd.0001853;
RA   Ricaldi J.N., Fouts D.E., Selengut J.D., Harkins D.M., Patra K.P.,
RA   Moreno A., Lehmann J.S., Purushe J., Sanka R., Torres M., Webster N.J.,
RA   Vinetz J.M., Matthias M.A.;
RT   "Whole Genome Analysis of Leptospira licerasiae Provides Insight into
RT   Leptospiral Evolution and Pathogenicity.";
RL   PLoS Negl. Trop. Dis. 6:E1853-E1853(2012).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EID99824.1}.
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DR   EMBL; AHOO02000013; EID99824.1; -; Genomic_DNA.
DR   RefSeq; WP_008592080.1; NZ_AHOO02000013.1.
DR   AlphaFoldDB; I0XLR7; -.
DR   PATRIC; fig|1049972.3.peg.3480; -.
DR   OrthoDB; 9806952at2; -.
DR   Proteomes; UP000004889; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR006674; HD_domain.
DR   InterPro; IPR006675; HDIG_dom.
DR   InterPro; IPR011624; Metal-dep_PHydrolase_7TM_extra.
DR   InterPro; IPR011621; Metal-dep_PHydrolase_7TM_intra.
DR   NCBIfam; TIGR00277; HDIG; 1.
DR   PANTHER; PTHR36442; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR   PANTHER; PTHR36442:SF1; CYCLIC-DI-AMP PHOSPHODIESTERASE PGPH; 1.
DR   Pfam; PF07698; 7TM-7TMR_HD; 1.
DR   Pfam; PF07697; 7TMR-HDED; 1.
DR   Pfam; PF01966; HD; 1.
DR   SMART; SM00471; HDc; 1.
DR   SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        31..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        330..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        363..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        395..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        442..457
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        513..535
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          564..726
FT                   /note="HD/PDEase"
FT                   /evidence="ECO:0000259|SMART:SM00471"
FT   REGION          774..802
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        775..795
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   802 AA;  90861 MW;  81A0DBD5B3FA38D1 CRC64;
     MFPLGSLLER GMAWITDTLT KIRPISFVRK FQVILTAITL IIVTWMLAIP FFGQDKINLS
     QDGPYSEGKN ALDKVVSTKD IVYEDEEKTK AKRLKAFQSA PNFFDRDYRV LIEVIRPAIQ
     EDMEKYREPK PTGEVKTSAE LLAAVPRWKN RSKEELELLL KTPGKSRVRD LVQQYSNLVF
     SNFCILRDQP ADYSAIRSAE ARIRNSGASG NKEQISSVEG TLVIPRMYLY RDSATVDALN
     RLAAEKLQAT DPQLLSVIQK LALTYLYSNP ACTFNAEETK NQKQAVMDRT EPVSSRINAG
     ETIVKAGEII TPDIYQKLLI VNRYATRANI ASIISILLIQ SIFVIIVYAF LKKYNPKRLN
     DVSSNVIVFT LIWSLVLWAY LASKAFFSFE NSYDSVFYFA LVIPTGMVCL ILSMIYDEQL
     SIAIGFFLSF FVFAASRYNP TSFILAFVMT VVAATYGRKM RKRIDFIKAG FYMALVQMLI
     SSSGYLFDSR NYWVAVPSGS HFRDLWESNI FRLYLLCLVN GFVCSTLTQL LLPIYEYVFN
     IPTRFKLLEL ADTGHPLLQD LLTKAPSTYT HTFLVAAMSE RAAQNLELDW LLTRVGVYFH
     DIGKIPNAGF FVENQHLIPK KENIDKNNPA KAAKIVIDHV LDGIEMAKKA RLPREVIDFI
     PEHHGTSTMA FFYHKALAEL SPSQKKKLKK ADFQYPGPKP QRKETAIVMI ADSLEAASRS
     LEEVTPEALD ILITKIVNGK LAENQLDECG LTLGDLEVVK HSFKEVLLSS LHSRPKYPKP
     EDTKALEEKN KNILGKHTPK SH
//