ID I0XLT4_9LEPT Unreviewed; 1097 AA.
AC I0XLT4;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Heavy metal efflux pump, CzcA family {ECO:0000313|EMBL:EID99841.1};
GN ORFNames=LEP1GSC185_2751 {ECO:0000313|EMBL:EID99841.1};
OS Leptospira licerasiae serovar Varillal str. VAR 010.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1049972 {ECO:0000313|EMBL:EID99841.1, ECO:0000313|Proteomes:UP000004889};
RN [1] {ECO:0000313|EMBL:EID99841.1, ECO:0000313|Proteomes:UP000004889}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VAR 010 {ECO:0000313|EMBL:EID99841.1};
RX PubMed=23145189; DOI=10.1371/journal.pntd.0001853;
RA Ricaldi J.N., Fouts D.E., Selengut J.D., Harkins D.M., Patra K.P.,
RA Moreno A., Lehmann J.S., Purushe J., Sanka R., Torres M., Webster N.J.,
RA Vinetz J.M., Matthias M.A.;
RT "Whole Genome Analysis of Leptospira licerasiae Provides Insight into
RT Leptospiral Evolution and Pathogenicity.";
RL PLoS Negl. Trop. Dis. 6:E1853-E1853(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EID99841.1}.
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DR EMBL; AHOO02000013; EID99841.1; -; Genomic_DNA.
DR RefSeq; WP_008592447.1; NZ_AHOO02000013.1.
DR AlphaFoldDB; I0XLT4; -.
DR PATRIC; fig|1049972.3.peg.3640; -.
DR OrthoDB; 9757876at2; -.
DR Proteomes; UP000004889; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004763; CusA-like.
DR NCBIfam; TIGR00914; 2A0601; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF17; CATION EFFLUX SYSTEM PROTEIN; 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 368..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 393..414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..465
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 477..503
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 543..560
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 887..906
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 912..931
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 943..961
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 990..1011
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1018..1044
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1074..1097
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1083..1097
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1097 AA; 122326 MW; 05CAA7E934611DC1 CRC64;
MINKLIESVL KYRIPTIISS IFVSILGIWA WTDIRKEAYS DIADTQVRLI AKFPGKAAVE
VEERVTLPIE RVLNAIPKVA VRRSRTINGL VVFQFVFEDG TDDYFARMRL MERVADADIP
EEVQPALGPM SSPVGEIFRY VVESSGNHTP MELRTIQDWI VMPKMLSIPG IADVVTFGGL
PKQFHIVTSP DKLVRYKLTI NDVIQAVQEN NLNTGGNLLL QGEQGFPIRS LGAIREAQHI
ENIVVKTVNG VPVFIRDLAT VEISHPIPSG VLGYTVRIDD QIMDVDSSVQ GLVAMRRWGD
PNEMGDRIRA KVKEINENYL PDGVQLRTTY DRSDLVNYTL RTIGRTLLEG VMVVSLVLIF
FIGSAKASLV VVATIPFALL FAFLLMDMTG IPASLLSLGA IDFGIVVDGA VIMVENIIRR
YRDATPADKS KGIIKLTAES AGEVGTEILF SILIIILAYL PIFSFERIEG RLFKPMAFTI
SFAILGALIF SMTVVPVLMT YMFRKYFESE RPGPIAWHNP FYAWVEERYK KLIDYLVERS
KKVVIYTFAA VTLFLGIGGY KLGTEFLPEM DEGGFNLRIF FPVGISLPEA RKFMPKIRET
IYKNEQVSVV LSQLGRNDDG TDPLPPNRLE VLVSLKDYDD WKERITKQEL LLRMKNDLEA
TLPGARISFS QPIMDNLSEA IMGTIADLAV FVSGQDLKVM RKLAEEILEI VKDMHGASEF
GIEQEADSPQ LTVRIDREAA ARYGINVSDI QQMVEAAIGM QRISTLYEGP SDIPPKTPAR
FGIVVRFSKD YRASKRAIEA MPIISPKGER VPLSQLAKIT LEDGPTMIFR QEGRRTITVR
TNVRGRDQGG FVNELRKKIQ AKIKLPEGYE VRYGGQYENL ARVGKKLAIV IPVTIAIIFG
VLFLLYRNLK YVYVALACLP LSLVGGMYAL LFRGYYFNVS SGVGFISLFG IATMSGVLFV
SRTNHLLQDE PTLTTKEAVT QAAVIQLRPM LMTMLLALLG LIPATLASGV GSDVQRPLAT
VIVGGLFSAL FLVLSVLPSL YLVVVGDRKH PVEEETFELH PEAYVSLYDE EEIEDATPSH
RNGSKKSKKK VTVKKKR
//
