ID I0XNF4_9LEPT Unreviewed; 485 AA.
AC I0XNF4;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE SubName: Full=7TM diverse intracellular signaling domain / bacterial transcriptional activator domain multi-domain protein {ECO:0000313|EMBL:EIE00412.1};
GN ORFNames=LEP1GSC185_3280 {ECO:0000313|EMBL:EIE00412.1};
OS Leptospira licerasiae serovar Varillal str. VAR 010.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1049972 {ECO:0000313|EMBL:EIE00412.1, ECO:0000313|Proteomes:UP000004889};
RN [1] {ECO:0000313|EMBL:EIE00412.1, ECO:0000313|Proteomes:UP000004889}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VAR 010 {ECO:0000313|EMBL:EIE00412.1};
RX PubMed=23145189; DOI=10.1371/journal.pntd.0001853;
RA Ricaldi J.N., Fouts D.E., Selengut J.D., Harkins D.M., Patra K.P.,
RA Moreno A., Lehmann J.S., Purushe J., Sanka R., Torres M., Webster N.J.,
RA Vinetz J.M., Matthias M.A.;
RT "Whole Genome Analysis of Leptospira licerasiae Provides Insight into
RT Leptospiral Evolution and Pathogenicity.";
RL PLoS Negl. Trop. Dis. 6:E1853-E1853(2012).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIE00412.1}.
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DR EMBL; AHOO02000012; EIE00412.1; -; Genomic_DNA.
DR AlphaFoldDB; I0XNF4; -.
DR PATRIC; fig|1049972.3.peg.3102; -.
DR Proteomes; UP000004889; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15831; BTAD; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR005158; BTAD.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR35807:SF1; TRANSCRIPTIONAL REGULATOR REDD; 1.
DR PANTHER; PTHR35807; TRANSCRIPTIONAL REGULATOR REDD-RELATED; 1.
DR Pfam; PF03704; BTAD; 1.
DR SMART; SM01043; BTAD; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 33..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 56..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..124
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 136..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 334..479
FT /note="Bacterial transcriptional activator"
FT /evidence="ECO:0000259|SMART:SM01043"
FT REGION 207..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 485 AA; 56178 MW; 4D19E2FA31129452 CRC64;
MQVAYGGYLF CFIQTINVDN PEKALIWERM ENATAAIFAT FIALFVNNYK KLFSRDFILL
YVFMNLILAG ILLQDPNAYT MSVAHPKHFP SLGIVIYETD QPTIMQFIFL SGILMIVWTV
IKVMNQFRKN RFRNHFLFYG LVLFFASLIA DILVASDILG IPYTSHFSFL ILMFCVDSFL
TVNKSEREVR IEFKESVSKW LTKPETSSFG SQAKETSGEG ADSKSLKEKG RNPKKLSVRA
LGPLELDLDG KKIPAAEYSS KKKLLKLIKL LLVRFGKGVH KEELLENLWP GMSEKNALNS
LHALLFRLRK ILGNPEAVVF AEDRLFFHPE LVEADFVEFE KRYETAGKLL RNKKEEEAVQ
SYREAQELYT GDFFEFDLYF PESELKREYL RKNLIEIYRI LCEYSQKAGD ANSLLSDSES
WIRLDDLDER AWRFHFESLQ SLDRKNEALR KFEDMKKILK KELGVEPDQE TVSLIEKIRV
TSPVG
//
