ID   I0XPD6_9LEPT            Unreviewed;       707 AA.
AC   I0XPD6;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=7TM diverse intracellular signaling domain / stage II sporulation protein E multi-domain protein {ECO:0000313|EMBL:EIE00744.1};
GN   ORFNames=LEP1GSC185_0129 {ECO:0000313|EMBL:EIE00744.1};
OS   Leptospira licerasiae serovar Varillal str. VAR 010.
OC   Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC   Leptospira.
OX   NCBI_TaxID=1049972 {ECO:0000313|EMBL:EIE00744.1, ECO:0000313|Proteomes:UP000004889};
RN   [1] {ECO:0000313|EMBL:EIE00744.1, ECO:0000313|Proteomes:UP000004889}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VAR 010 {ECO:0000313|EMBL:EIE00744.1};
RX   PubMed=23145189; DOI=10.1371/journal.pntd.0001853;
RA   Ricaldi J.N., Fouts D.E., Selengut J.D., Harkins D.M., Patra K.P.,
RA   Moreno A., Lehmann J.S., Purushe J., Sanka R., Torres M., Webster N.J.,
RA   Vinetz J.M., Matthias M.A.;
RT   "Whole Genome Analysis of Leptospira licerasiae Provides Insight into
RT   Leptospiral Evolution and Pathogenicity.";
RL   PLoS Negl. Trop. Dis. 6:E1853-E1853(2012).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EIE00744.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AHOO02000011; EIE00744.1; -; Genomic_DNA.
DR   RefSeq; WP_008590819.1; NZ_AHOO02000011.1.
DR   AlphaFoldDB; I0XPD6; -.
DR   PATRIC; fig|1049972.3.peg.2612; -.
DR   OrthoDB; 311727at2; -.
DR   Proteomes; UP000004889; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.60.40.10; PPM-type phosphatase domain; 1.
DR   InterPro; IPR011623; 7TMR_DISM_rcpt_extracell_dom1.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR036457; PPM-type-like_dom_sf.
DR   InterPro; IPR001932; PPM-type_phosphatase-like_dom.
DR   PANTHER; PTHR43156:SF2; MULTIDOMAIN REGULATORY PROTEIN RV1364C; 1.
DR   PANTHER; PTHR43156; STAGE II SPORULATION PROTEIN E-RELATED; 1.
DR   Pfam; PF07695; 7TMR-DISM_7TM; 1.
DR   Pfam; PF07228; SpoIIE; 1.
DR   SMART; SM00331; PP2C_SIG; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        231..253
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        260..279
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        299..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        329..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        354..375
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        382..404
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        410..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          488..704
FT                   /note="PPM-type phosphatase"
FT                   /evidence="ECO:0000259|SMART:SM00331"
FT   COILED          435..466
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   707 AA;  79837 MW;  C5EE6985FF42A8D4 CRC64;
     MEHFFPILNA FLILSFRIRL KRIFFQMKKA ITFLILIYLP FFFSGCSESS AKVEHPAIVQ
     GVLELKNYDL EEQGPILLSG LWKFRWLYWK SSGLESQNSY EVVSVPSSWN GKNGSRLGEG
     YGTYELSLKL NRNYGELAFI LQEQSSSYFL YVNGKLLASC GEVEFPSSSD ITIFEVKPAW
     CNKLVKFTPE VEDLTIDVQI ANRDHRLGGF WAPIRFGTAS SMEKTWNAER FLDLFLAGGL
     FCIGLLHLIY AAVRKGESAS MYFGTFCLIM AARGLFSGTR IISEYIDFLK YHHYVRIEYV
     TFYLAIPVFL SYILSVFPRE LKRILVDLVW WIAVGACIVV LVFPVRIFTF TITVYYLVAF
     LAGTLGLFSL TKAALRRRKG ALIILAGFVF IYAAMIHDIL YATFYLDTGY FTNIGAFVFI
     VAQSVFLSIR SSESLDRLLD LSRNLERRVE ERTKQLRNAL RLIQNDLNVA REIQKGLLNL
     EDTAEKKIGK IKFGILHKPL AEVGGDLYDI TELPNGKIRI FLADAPGHGI QAALITILIR
     SIYEDLRLKE ESPGKLLSAI GSLFHGKFGN VSTFFSASIL EISSDGKKLT LSLAGSPPVL
     VQNKDEEHII ECENPLVGLL ENFHFEDKEV SLTPGFRILC FTDGLTESSR LPGDFYGIER
     VLASLRNGDS QSLEELLSGI QEDLFRFLGS SEPKDDILVL GIEDQRS
//