ID I0XR73_9LEPT Unreviewed; 1095 AA.
AC I0XR73;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE SubName: Full=Heavy metal efflux pump, CzcA family {ECO:0000313|EMBL:EIE01381.1};
GN ORFNames=LEP1GSC185_3504 {ECO:0000313|EMBL:EIE01381.1};
OS Leptospira licerasiae serovar Varillal str. VAR 010.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1049972 {ECO:0000313|EMBL:EIE01381.1, ECO:0000313|Proteomes:UP000004889};
RN [1] {ECO:0000313|EMBL:EIE01381.1, ECO:0000313|Proteomes:UP000004889}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VAR 010 {ECO:0000313|EMBL:EIE01381.1};
RX PubMed=23145189; DOI=10.1371/journal.pntd.0001853;
RA Ricaldi J.N., Fouts D.E., Selengut J.D., Harkins D.M., Patra K.P.,
RA Moreno A., Lehmann J.S., Purushe J., Sanka R., Torres M., Webster N.J.,
RA Vinetz J.M., Matthias M.A.;
RT "Whole Genome Analysis of Leptospira licerasiae Provides Insight into
RT Leptospiral Evolution and Pathogenicity.";
RL PLoS Negl. Trop. Dis. 6:E1853-E1853(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIE01381.1}.
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DR EMBL; AHOO02000008; EIE01381.1; -; Genomic_DNA.
DR RefSeq; WP_008590291.1; NZ_AHOO02000008.1.
DR AlphaFoldDB; I0XR73; -.
DR PATRIC; fig|1049972.3.peg.2198; -.
DR OrthoDB; 9798415at2; -.
DR Proteomes; UP000004889; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.1430; Multidrug efflux transporter AcrB pore domain; 2.
DR Gene3D; 3.30.70.1440; Multidrug efflux transporter AcrB pore domain; 1.
DR Gene3D; 3.30.70.1320; Multidrug efflux transporter AcrB pore domain like; 1.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR027463; AcrB_DN_DC_subdom.
DR InterPro; IPR001036; Acrflvin-R.
DR InterPro; IPR004763; CusA-like.
DR NCBIfam; TIGR00914; 2A0601; 1.
DR PANTHER; PTHR32063; -; 1.
DR PANTHER; PTHR32063:SF24; CATION EFFLUX SYSTEM (ACRB_ACRD_ACRF FAMILY); 1.
DR Pfam; PF00873; ACR_tran; 1.
DR PRINTS; PR00702; ACRIFLAVINRP.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 337..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 438..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..505
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 536..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 872..891
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 898..917
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 923..945
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 978..995
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1001..1028
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 1095 AA; 120081 MW; 6302163073AA4F9A CRC64;
MIDKLIRISI KNRIFVLILT AGVTIVGFYN AYQLSIDAIP DITNVQVSVV TQSPGLSPVE
VEQFITYPIE MELTGVPHVT EIRSISRTGV SSVTVIFKDG TDIYFARQLI NERLRAAEAV
IPKGYGSPEL SPIATGLGDI YEFVLTSDRH NPEELRTYME WELAREIKST EGIIDVNIIG
GEARQYQIKI DPQRLAVHNI TLSQLCDKLE TANQNTGGGY ISKGAEQIVI RGESQFKTLD
EIRNVAVQTE RDGVPLLLGQ IATVETGPAL RFGLMTKDAK GEVVGATAMM LMGQNSLEVV
KRVKEKIEIL RARLPEGMKI VTFYDRSEFI GRTLGTIFTN LAEAAVLVII VLIFALGTVK
GALLVSLSIP IPMLAATIFM RMFGIVGNLM SLGALDFGLL VDGTIVMLES VLHGFILKQA
FYEQQNSQED RKLAAEQIIT DSCVRVARAA AFSVGIILLV YLPLMTLEGV EGRMFKPMAM
TVAISLAMAL LFSLTTFPAA ASILFQTPVF HHSKFWDRAE ELYMQLLDFG MANKKLFLRA
GLGVFAVSLI LGSTLGSEFL PRIDEGEFAI DIKRLPSTSI NYSRDTNTEM EKVIAQFPEA
TSVVSKMGRG ESAAEPIGTE EGESMVKLIP SKEWTTASSR DELMDKMKDA ILKSVPSSTI
SLSQPIENRV NALLSGSKAD VVIKIYGDDL QTLKDTASKF ADKIKKVPGA ADLRVQRVLG
LPLIQIKSDR QKMARYGVAA EEILTTVESL RIGRKAGKVF EGFKRFDLVV RLQLDVSDLD
KLENIPVMTS TGVTVPLGQV ATIEFVEGPA AIYRESLKRR IMVEANVRGR DLVGFVNEAQ
KVTADIEKNL PEGYRTDWGG QFENFQRAKN RLMLVVPIAL GIIFVMLIAA FGNIYYAAGV
FIVVPLAVAG GIIGLVLRGL PFSIPAGVGF IAVSGIAVLN GVVYASTLKE ELEKGIAVSK
AVLSAGLHSL RPVMTTEIIA AVGFIPMAIS TMAGAEVQRP LATVVIFGVI VATVLSRVLL
PIVMEFLLNI YQDQERRKEA RKRKLESEFQ ASRALERIPE TLEEVSWDSE EIQEEQEEVL
SSKSKRSKNG LKKKK
//