ID I0XWP4_9LEPT Unreviewed; 664 AA.
AC I0XWP4;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Cache domain / HAMP domain / methyl-accepting chemotaxis protein signaling domain multi-domain protein {ECO:0000313|EMBL:EIE03302.1};
GN ORFNames=LEP1GSC185_2114 {ECO:0000313|EMBL:EIE03302.1};
OS Leptospira licerasiae serovar Varillal str. VAR 010.
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=1049972 {ECO:0000313|EMBL:EIE03302.1, ECO:0000313|Proteomes:UP000004889};
RN [1] {ECO:0000313|EMBL:EIE03302.1, ECO:0000313|Proteomes:UP000004889}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=VAR 010 {ECO:0000313|EMBL:EIE03302.1};
RX PubMed=23145189; DOI=10.1371/journal.pntd.0001853;
RA Ricaldi J.N., Fouts D.E., Selengut J.D., Harkins D.M., Patra K.P.,
RA Moreno A., Lehmann J.S., Purushe J., Sanka R., Torres M., Webster N.J.,
RA Vinetz J.M., Matthias M.A.;
RT "Whole Genome Analysis of Leptospira licerasiae Provides Insight into
RT Leptospiral Evolution and Pathogenicity.";
RL PLoS Negl. Trop. Dis. 6:E1853-E1853(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the methyl-accepting chemotaxis (MCP) protein
CC family. {ECO:0000256|ARBA:ARBA00029447}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIE03302.1}.
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DR EMBL; AHOO02000005; EIE03302.1; -; Genomic_DNA.
DR RefSeq; WP_008595731.1; NZ_AHOO02000005.1.
DR AlphaFoldDB; I0XWP4; -.
DR PATRIC; fig|1049972.3.peg.1447; -.
DR OrthoDB; 9760371at2; -.
DR Proteomes; UP000004889; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:UniProtKB-KW.
DR CDD; cd06225; HAMP; 1.
DR CDD; cd18773; PDC1_HK_sensor; 1.
DR CDD; cd12912; PDC2_MCP_like; 1.
DR Gene3D; 1.10.287.950; Methyl-accepting chemotaxis protein; 2.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR033479; dCache_1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR004089; MCPsignal_dom.
DR InterPro; IPR029151; Sensor-like_sf.
DR PANTHER; PTHR32089:SF92; LYSOZYME-LIKE PROTEIN-RELATED; 1.
DR PANTHER; PTHR32089; METHYL-ACCEPTING CHEMOTAXIS PROTEIN MCPB; 1.
DR Pfam; PF02743; dCache_1; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF00015; MCPsignal; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00283; MA; 1.
DR SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR SUPFAM; SSF103190; Sensory domain-like; 1.
DR PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
DR PROSITE; PS50885; HAMP; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Chemotaxis {ECO:0000256|ARBA:ARBA00022500};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transducer {ECO:0000256|ARBA:ARBA00023224, ECO:0000256|PROSITE-
KW ProRule:PRU00284};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 283..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 307..359
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 392..628
FT /note="Methyl-accepting transducer"
FT /evidence="ECO:0000259|PROSITE:PS50111"
SQ SEQUENCE 664 AA; 71978 MW; 13295D6E59D6CC9F CRC64;
MQKSSLKFIL LGAGVLILTV LALLISGNAY YFGQKKITEN HLNQMQNVVA VVAQEFDAFL
LSHTNVAKTL AADPRAIQTA LTGKPIAGDF FKEVHQRYGI YENIFVMSLD GEKRILADSL
DGKSLGYKAQ GDELKENVAA VKEGKYYLGP PQKSPITGLP VAVISVPIRN GANIVGVLNI
ALSFEDVSEK VINKIRIGEQ GYVSVMSQAG LVIAHPKKEM IMNLDVAKEP YGKKMLELKS
GEIFEFSFRG SDRYSTVSRL DQWRMSVIAI QPKTEIREAL VELLLSIGII SLSTVGISIF
LLYILLKKRL DPLENASKLF QTMSKGDLTA DIQVVYNDEI GAMSADLNSF IASLRSSLTD
IQRIAMELAS SAEELTVSSQ SFATGAQSTA ASSEQMSATV EEMSAGMENI SSVTDRQYSN
ILEFHTKIKE LSSGVRKIGS EIKNTLQIAE SISQEAKKGE SSLTGMSNMI ENILKSSGEM
KSIIGIINDI SDQTQLLALN AAIEAARAGE AGKGFAVVAE EISKLSVKTA SSIKSIGEMI
NKNNSELDEG AKGIRSSVEI LHSIIKNVDS VGEAMNHLFE ITSAQESVNR SVDEQSDRVG
TEAEAVKLAT DEQKRAVREI AQVITQINEH TLNTASGSEQ MSSSAQNLAT TAEVLKNITE
KFKI
//
