ID I0YKS9_COCSC Unreviewed; 1095 AA.
AC I0YKS9;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=beta-galactosidase {ECO:0000256|ARBA:ARBA00012756};
DE EC=3.2.1.23 {ECO:0000256|ARBA:ARBA00012756};
DE AltName: Full=Lactase {ECO:0000256|ARBA:ARBA00032230};
GN ORFNames=COCSUDRAFT_20201 {ECO:0000313|EMBL:EIE18998.1};
OS Coccomyxa subellipsoidea (strain C-169) (Green microalga).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Trebouxiophyceae;
OC Trebouxiophyceae incertae sedis; Elliptochloris clade; Coccomyxa;
OC Coccomyxa subellipsoidea.
OX NCBI_TaxID=574566 {ECO:0000313|EMBL:EIE18998.1, ECO:0000313|Proteomes:UP000007264};
RN [1] {ECO:0000313|EMBL:EIE18998.1, ECO:0000313|Proteomes:UP000007264}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C-169 {ECO:0000313|EMBL:EIE18998.1,
RC ECO:0000313|Proteomes:UP000007264};
RX PubMed=22630137; DOI=10.1186/gb-2012-13-5-r39;
RA Blanc G., Agarkova I., Grimwood J., Kuo A., Brueggeman A., Dunigan D.,
RA Gurnon J., Ladunga I., Lindquist E., Lucas S., Pangilinan J., Proschold T.,
RA Salamov A., Schmutz J., Weeks D., Yamada T., Claverie J.M., Grigoriev I.,
RA Van Etten J., Lomsadze A., Borodovsky M.;
RT "The genome of the polar eukaryotic microalga coccomyxa subellipsoidea
RT reveals traits of cold adaptation.";
RL Genome Biol. 13:R39-R39(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal non-reducing beta-D-galactose residues
CC in beta-D-galactosides.; EC=3.2.1.23;
CC Evidence={ECO:0000256|ARBA:ARBA00001412};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family.
CC {ECO:0000256|ARBA:ARBA00007401, ECO:0000256|RuleBase:RU361154}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIE18998.1}.
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DR EMBL; AGSI01000021; EIE18998.1; -; Genomic_DNA.
DR RefSeq; XP_005643542.1; XM_005643485.1.
DR AlphaFoldDB; I0YKS9; -.
DR STRING; 574566.I0YKS9; -.
DR GeneID; 17036948; -.
DR KEGG; csl:COCSUDRAFT_20201; -.
DR eggNOG; KOG2024; Eukaryota.
DR OrthoDB; 276651at2759; -.
DR Proteomes; UP000007264; Unassembled WGS sequence.
DR GO; GO:0009341; C:beta-galactosidase complex; IEA:InterPro.
DR GO; GO:0004565; F:beta-galactosidase activity; IEA:UniProtKB-EC.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:1901575; P:organic substance catabolic process; IEA:UniProt.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR004199; B-gal_small/dom_5.
DR InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR006101; Glyco_hydro_2.
DR InterPro; IPR023232; Glyco_hydro_2_AS.
DR InterPro; IPR006103; Glyco_hydro_2_cat.
DR InterPro; IPR023230; Glyco_hydro_2_CS.
DR InterPro; IPR006102; Glyco_hydro_2_Ig-like.
DR InterPro; IPR006104; Glyco_hydro_2_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR032312; LacZ_4.
DR PANTHER; PTHR46323; BETA-GALACTOSIDASE; 1.
DR PANTHER; PTHR46323:SF2; BETA-GALACTOSIDASE; 1.
DR Pfam; PF02929; Bgal_small_N; 1.
DR Pfam; PF00703; Glyco_hydro_2; 1.
DR Pfam; PF02836; Glyco_hydro_2_C; 1.
DR Pfam; PF02837; Glyco_hydro_2_N; 1.
DR Pfam; PF16353; LacZ_4; 1.
DR PRINTS; PR00132; GLHYDRLASE2.
DR SMART; SM01038; Bgal_small_N; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 2.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR PROSITE; PS00719; GLYCOSYL_HYDROL_F2_1; 1.
DR PROSITE; PS00608; GLYCOSYL_HYDROL_F2_2; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361154};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361154};
KW Reference proteome {ECO:0000313|Proteomes:UP000007264}.
FT DOMAIN 759..1060
FT /note="Beta galactosidase small chain/"
FT /evidence="ECO:0000259|SMART:SM01038"
FT REGION 842..865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1095 AA; 121735 MW; ED98827EF72375F7 CRC64;
MAIKSLPRDW ENPSVFSRNK CRSHVPLRAH PTPESALLYF LKDPKAADTA NLLSLNSSEW
SFHLYDRPED VPDAFSTPEF DDGLWGKIEV PANWECQGHG TPIYTNFQYP WPITAPFVPA
ENPTGCYRLW FDVPSGWKDR RVFLHFEAVN NACYVWVNGQ QLGYSQDSCL PAEFEVTTVL
QPGRNLLSVQ VLRFSDGSYL EDMDHWWLSG IYRDVFLLSK PVTHITDFVV NEDQPSGFAE
AVPAVEIEIT DQDHWISVDN TIRATHAEAG VGGLAIVGTS FPPFPFDKQL ARSVDIDMAT
AGRLPALWSA EEPNLYILVL SLVTKQGEHL DSESTQVGFR EVVIEGRQLL VNKRPILVKG
VNRHEHDERR GKAVTEEGML ADIYLLKQLN FNSVRCSHYP NAPRWYELCN QYGLYLVDEA
NVETHGFDPA LNNNRVVPAN NPLWLHAIVD RGMRMLERDK NHPSIIIWSL GNEAGYGPAH
LAMAGYIRAR DSSRPVHYEG GGSRTAATDI LCPMYARINQ IEAWANEKAE TRPLIQCEYA
HAMGNSNGNY KEYWESFEKH PYLQGGFIWD WVDQGLLHKV KDVEGNDVEA WGYGGDFGDP
VHDAQFCING LIWPNRVPHP GAFECKALKE SPNGGLGGLI VRAKNKNTFS SSANLLLSWR
VLLDGVPLLV GDPAQRGLGG WYPGGSVAIA PQVFLEMRAQ LSTAMPWAPM GHVVAEQQLL
VPSDWIRDDD DAMPEHAPPP LGKPLQFTQE ERGGRKVHNV TGANDLHVEV NTQTGSLDRW
EVGGHSLLAQ GVTPCLFRAP LDNDLGGSGK TSFAARWKEA GLDCLEVVAD TVKSSVQQIS
DSAVKVPDAP SGAPQEHPLP DAPTPSVEAE VAVAVQYTVH GDGSLRVDWH IDASRALPAS
PPPPLFSSLP RIGMHLGVPA QFSRVHWYGR GPHESYPDRK YGAFLRQYSL DHVQEMHVPY
IFPSENGGRA DTRWVSLSDE DGVGLAAVTL SDPFQMNASR FSIATLMAAK HDYELSADPF
THLHLDHRHM GVGGDDSWSP SLHKEYAVEP GEYKFSVLLA PVLPNKEVTA PETAASLWRQ
QVIDHFLEIR CRTTV
//
