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Database: UniProt
Entry: I0Z0J1_COCSC
LinkDB: I0Z0J1_COCSC
Original site: I0Z0J1_COCSC 
ID   I0Z0J1_COCSC            Unreviewed;       486 AA.
AC   I0Z0J1;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   08-MAY-2019, entry version 27.
DE   RecName: Full=UDP-glucose 6-dehydrogenase {ECO:0000256|PIRNR:PIRNR000124};
DE            EC=1.1.1.22 {ECO:0000256|PIRNR:PIRNR000124};
GN   ORFNames=COCSUDRAFT_23305 {ECO:0000313|EMBL:EIE24160.1};
OS   Coccomyxa subellipsoidea (strain C-169) (Green microalga).
OC   Eukaryota; Viridiplantae; Chlorophyta; Trebouxiophyceae;
OC   Elliptochloris clade; Coccomyxa.
OX   NCBI_TaxID=574566 {ECO:0000313|EMBL:EIE24160.1, ECO:0000313|Proteomes:UP000007264};
RN   [1] {ECO:0000313|EMBL:EIE24160.1, ECO:0000313|Proteomes:UP000007264}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C-169 {ECO:0000313|EMBL:EIE24160.1,
RC   ECO:0000313|Proteomes:UP000007264};
RX   PubMed=22630137; DOI=10.1186/gb-2012-13-5-r39;
RA   Blanc G., Agarkova I., Grimwood J., Kuo A., Brueggeman A., Dunigan D.,
RA   Gurnon J., Ladunga I., Lindquist E., Lucas S., Pangilinan J.,
RA   Proschold T., Salamov A., Schmutz J., Weeks D., Yamada T.,
RA   Claverie J.M., Grigoriev I., Van Etten J., Lomsadze A., Borodovsky M.;
RT   "The genome of the polar eukaryotic microalga coccomyxa subellipsoidea
RT   reveals traits of cold adaptation.";
RL   Genome Biol. 13:R39-R39(2012).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH +
CC         UDP-alpha-D-glucuronate; Xref=Rhea:RHEA:23596,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:58052, ChEBI:CHEBI:58885;
CC         EC=1.1.1.22; Evidence={ECO:0000256|PIRNR:PIRNR000124};
CC   -!- SIMILARITY: Belongs to the UDP-glucose/GDP-mannose dehydrogenase
CC       family. {ECO:0000256|PIRNR:PIRNR000124}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EIE24160.1}.
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DR   EMBL; AGSI01000006; EIE24160.1; -; Genomic_DNA.
DR   RefSeq; XP_005648704.1; XM_005648647.1.
DR   STRING; 248742.XP_005648704.1; -.
DR   GeneID; 17042158; -.
DR   KEGG; csl:COCSUDRAFT_23305; -.
DR   KO; K00012; -.
DR   OrthoDB; 915490at2759; -.
DR   Proteomes; UP000007264; Unassembled WGS sequence.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0003979; F:UDP-glucose 6-dehydrogenase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR017476; UDP-Glc/GDP-Man.
DR   InterPro; IPR014027; UDP-Glc/GDP-Man_DH_C.
DR   InterPro; IPR036220; UDP-Glc/GDP-Man_DH_C_sf.
DR   InterPro; IPR014026; UDP-Glc/GDP-Man_DH_dimer.
DR   InterPro; IPR001732; UDP-Glc/GDP-Man_DH_N.
DR   InterPro; IPR028356; UDPglc_DH_euk.
DR   PANTHER; PTHR11374; PTHR11374; 1.
DR   Pfam; PF00984; UDPG_MGDP_dh; 1.
DR   Pfam; PF03720; UDPG_MGDP_dh_C; 1.
DR   Pfam; PF03721; UDPG_MGDP_dh_N; 1.
DR   PIRSF; PIRSF500133; UDPglc_DH_euk; 1.
DR   PIRSF; PIRSF000124; UDPglc_GDPman_dh; 1.
DR   SMART; SM00984; UDPG_MGDP_dh_C; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   SUPFAM; SSF52413; SSF52413; 1.
DR   TIGRFAMs; TIGR03026; NDP-sugDHase; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007264};
KW   NAD {ECO:0000256|PIRNR:PIRNR000124, ECO:0000256|PIRSR:PIRSR500133-3};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000124};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007264}.
FT   DOMAIN      333    462       UDPG_MGDP_dh_C. {ECO:0000259|SMART:
FT                                SM00984}.
FT   NP_BIND      11     16       NAD. {ECO:0000256|PIRSR:PIRSR500133-3}.
FT   NP_BIND      89     93       NAD. {ECO:0000256|PIRSR:PIRSR500133-3}.
FT   NP_BIND     130    131       NAD. {ECO:0000256|PIRSR:PIRSR500133-3}.
FT   NP_BIND     277    280       NAD. {ECO:0000256|PIRSR:PIRSR500133-3}.
FT   ACT_SITE    277    277       Nucleophile. {ECO:0000256|PIRSR:
FT                                PIRSR500133-1}.
FT   BINDING      36     36       NAD. {ECO:0000256|PIRSR:PIRSR500133-3}.
FT   BINDING      41     41       NAD. {ECO:0000256|PIRSR:PIRSR500133-3}.
FT   BINDING     166    166       NAD. {ECO:0000256|PIRSR:PIRSR500133-3}.
FT   BINDING     347    347       NAD. {ECO:0000256|PIRSR:PIRSR500133-3}.
SQ   SEQUENCE   486 AA;  53169 MW;  9C86CE73F557FF89 CRC64;
     MAKPTRICCI GAGYVGGPTM AMIALKCPEI IVTVVDLNES RINAWNSETL PIYEPGLFEV
     VKACRGKNLF FSTDCRYHVA QADIVFVSVN TPTKMSGVGA GKAADLAYWE GAARMIASVS
     TSSKIIVEKS TVPVKTAEAI GKVLRRNCPH PDVQFEILSN PEFLAEGTAI QDLTNPDRVL
     IGGKETESGR AAVAALASVY AHWVPAERIL CANLWSAELS KLTANAMLAQ RISSVNSISA
     LCEATGADVQ QVAHALGTDS RIGPKFLNAS VGFGGSCFQK DILNLVYICE SVGLKRVADY
     WHSVIQINDY QKHRFVEMVI GSMFNTVSGK KIAILGFAFK KDTGDTRETP AIDVCHGLIA
     DDARLSIYDP QVQQDQIFRD LSMPKFQWDH PMLPNGAQVP FSSREIDRTV SVSSDPYKAC
     AGSHALCVMT EWDEFKALDF DRIFASMSKP AFVFDGRNIL DHERLRSIGF IVYALGKPLE
     PFLQKQ
//
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