ID I0Z5Q1_COCSC Unreviewed; 806 AA.
AC I0Z5Q1;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE SubName: Full=DEAD-domain-containing protein {ECO:0000313|EMBL:EIE25970.1};
GN ORFNames=COCSUDRAFT_64920 {ECO:0000313|EMBL:EIE25970.1};
OS Coccomyxa subellipsoidea (strain C-169) (Green microalga).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Trebouxiophyceae;
OC Trebouxiophyceae incertae sedis; Elliptochloris clade; Coccomyxa;
OC Coccomyxa subellipsoidea.
OX NCBI_TaxID=574566 {ECO:0000313|EMBL:EIE25970.1, ECO:0000313|Proteomes:UP000007264};
RN [1] {ECO:0000313|EMBL:EIE25970.1, ECO:0000313|Proteomes:UP000007264}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C-169 {ECO:0000313|EMBL:EIE25970.1,
RC ECO:0000313|Proteomes:UP000007264};
RX PubMed=22630137; DOI=10.1186/gb-2012-13-5-r39;
RA Blanc G., Agarkova I., Grimwood J., Kuo A., Brueggeman A., Dunigan D.,
RA Gurnon J., Ladunga I., Lindquist E., Lucas S., Pangilinan J., Proschold T.,
RA Salamov A., Schmutz J., Weeks D., Yamada T., Claverie J.M., Grigoriev I.,
RA Van Etten J., Lomsadze A., Borodovsky M.;
RT "The genome of the polar eukaryotic microalga coccomyxa subellipsoidea
RT reveals traits of cold adaptation.";
RL Genome Biol. 13:R39-R39(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX54/DBP10
CC subfamily. {ECO:0000256|ARBA:ARBA00010379}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIE25970.1}.
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DR EMBL; AGSI01000003; EIE25970.1; -; Genomic_DNA.
DR RefSeq; XP_005650514.1; XM_005650457.1.
DR AlphaFoldDB; I0Z5Q1; -.
DR STRING; 574566.I0Z5Q1; -.
DR GeneID; 17043974; -.
DR KEGG; csl:COCSUDRAFT_64920; -.
DR eggNOG; KOG0337; Eukaryota.
DR OrthoDB; 5475716at2759; -.
DR Proteomes; UP000007264; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd18787; SF2_C_DEAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR012541; DBP10_C.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR PANTHER; PTHR47959; ATP-DEPENDENT RNA HELICASE RHLE-RELATED; 1.
DR PANTHER; PTHR47959:SF8; RNA HELICASE; 1.
DR Pfam; PF08147; DBP10CT; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR SMART; SM01123; DBP10CT; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS51195; Q_MOTIF; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007264};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 44..72
FT /note="DEAD-box RNA helicase Q"
FT /evidence="ECO:0000259|PROSITE:PS51195"
FT DOMAIN 75..248
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 275..421
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 575..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 691..713
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 748..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 44..72
FT /note="Q motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00552"
FT COMPBIAS 765..788
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 789..806
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 806 AA; 87959 MW; C8EB12C0A8D061CE CRC64;
MEDHDARQGE GTEVVEFGTA EEPQIVSGRR AKAIKDKRKK LKPGSFETLG LSPVIIRGIK
RKGYQLPTPI QRRTLPLALT GQDVVGMART GSGKTAAFVI PMLERLREHS PRAGARALIL
APTRELTLQL HKVVKELSRY TDLRTAVLVG GDSMEAQFAE LAANPDILLA TPGRLMHHLQ
EVEGMSLQTV QYCVFDEADQ LFEMGFAEQL RAVLSKMGDA RQTLLFSATL PAALAEFARA
GLKNPAFVRL DADTKLSPNL QLCFACLRQE DKTAALLWLL HEVIPEGSPT LIFTATRHHV
EFLHTLLTRE GLRSACVYGQ MDQAARRIHS GKFRAGQVNI LIVTDVAARG IDIPLLDNVI
NYDFPARPKL FVHRAGRAAR AGRSGTAYSL FTREELPYLL DLHLFLSRGV QPAPVASLAQ
AAAVAGGASS DVSLYGTFPQ AALEDNAERV RAAVANASEL QGLQRSCANA WLLYKRTRPA
ASPESVTRAR SMPAAGVHPD LAAACPQSSL AGLEAQEDMA NIAARLRAYR PSATVLEAEV
APARRGEGAG CMSGPGMTAS HGPAGFLEVM RLKRGRSKRQ QENKAAGDAV SQGSVDPAAL
RRAASEAARE GDQALEQGRF RDAECFIAST KSSRYEDEGF AVHRSGGDDL MSAAVLDLME
DDTAGMAAQQ RRFHWDKRKR CYIQLQPNEK VQAGKRKRTE SGKLGQKGSQ PSGLYKKWVR
SSKMRVPATG ELPDAGVKDT ANLSDRFKMG GRGWKNPFKS QGPTAHIRDE LKNQDQVRKE
GKLKRRKLEA VQHASKKKKS SGKRKI
//
