ID I1A5R1_9MOLU Unreviewed; 169 AA.
AC I1A5R1;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=dihydrofolate reductase {ECO:0000256|ARBA:ARBA00012856};
DE EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856};
GN ORFNames=MCANUFG4_02076 {ECO:0000313|EMBL:EIE41832.1};
OS Mycoplasmopsis canis UFG4.
OC Bacteria; Mycoplasmatota; Mollicutes; Mycoplasmataceae; Mycoplasmopsis.
OX NCBI_TaxID=1131455 {ECO:0000313|EMBL:EIE41832.1, ECO:0000313|Proteomes:UP000006229};
RN [1] {ECO:0000313|EMBL:EIE41832.1, ECO:0000313|Proteomes:UP000006229}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UFG4 {ECO:0000313|EMBL:EIE41832.1,
RC ECO:0000313|Proteomes:UP000006229};
RX PubMed=22815452; DOI=10.1128/JB.00664-12;
RA Brown D.R., May M., Michaels D.L., Barbet A.F.;
RT "Genome annotation of five Mycoplasma canis strains.";
RL J. Bacteriol. 194:4138-4139(2012).
CC -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-
CC tetrahydrofolate from 7,8-dihydrofolate: step 1/1.
CC {ECO:0000256|ARBA:ARBA00004903}.
CC -!- SIMILARITY: Belongs to the dihydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00009539}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EIE41832.1}.
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DR EMBL; AJFU01000005; EIE41832.1; -; Genomic_DNA.
DR RefSeq; WP_004797168.1; NZ_AJFU01000005.1.
DR AlphaFoldDB; I1A5R1; -.
DR PATRIC; fig|1131455.3.peg.421; -.
DR OrthoDB; 9804315at2; -.
DR UniPathway; UPA00077; UER00158.
DR Proteomes; UP000006229; Unassembled WGS sequence.
DR GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00209; DHFR; 1.
DR Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR InterPro; IPR012259; DHFR.
DR InterPro; IPR024072; DHFR-like_dom_sf.
DR InterPro; IPR001796; DHFR_dom.
DR PANTHER; PTHR48069; DIHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR48069:SF3; DIHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF00186; DHFR_1; 1.
DR PRINTS; PR00070; DHFR.
DR SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR PROSITE; PS51330; DHFR_2; 1.
PE 3: Inferred from homology;
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW Reference proteome {ECO:0000313|Proteomes:UP000006229}.
FT DOMAIN 1..169
FT /note="DHFR"
FT /evidence="ECO:0000259|PROSITE:PS51330"
SQ SEQUENCE 169 AA; 20141 MW; 9FA8887D9B0CF5F9 CRC64;
MILASTISGL IGLKDNTLPW YIPKDLNFFS EQTKNSILIF GNNTFQNLPE KMFINKKNRK
FYVLSIEKIR QNTNFIDKEF NSISELELFL TENNNKNKNI YLCGGKFIYE TFFNHASELY
LTTIKNNLDK NFKDEEKIIL DIKKIKSFFK NKEKIIYEDF QIKIEKYSK
//