ID   I1BHW2_RHIO9            Unreviewed;       615 AA.
AC   I1BHW2;
DT   13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT   13-JUN-2012, sequence version 1.
DT   24-JAN-2024, entry version 35.
DE   RecName: Full=SPX domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=RO3G_00496 {ECO:0000313|EMBL:EIE75792.1};
OS   Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS   43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC   Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC   Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX   NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE75792.1, ECO:0000313|Proteomes:UP000009138};
RN   [1] {ECO:0000313|EMBL:EIE75792.1, ECO:0000313|Proteomes:UP000009138}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC   {ECO:0000313|Proteomes:UP000009138};
RX   PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA   Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA   Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA   Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA   Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA   Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA   Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT   "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT   whole-genome duplication.";
RL   PLoS Genet. 5:E1000549-E1000549(2009).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   EMBL; CH476732; EIE75792.1; -; Genomic_DNA.
DR   AlphaFoldDB; I1BHW2; -.
DR   STRING; 246409.I1BHW2; -.
DR   VEuPathDB; FungiDB:RO3G_00496; -.
DR   eggNOG; KOG1161; Eukaryota.
DR   eggNOG; KOG4580; Eukaryota.
DR   InParanoid; I1BHW2; -.
DR   OMA; LVYEVPY; -.
DR   OrthoDB; 1420500at2759; -.
DR   Proteomes; UP000009138; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.20.100.30; VTC, catalytic tunnel domain; 1.
DR   InterPro; IPR003807; DUF202.
DR   InterPro; IPR018966; VTC_domain.
DR   InterPro; IPR042267; VTC_sf.
DR   PANTHER; PTHR46140; VACUOLAR TRANSPORTER CHAPERONE 1-RELATED; 1.
DR   PANTHER; PTHR46140:SF1; VACUOLAR TRANSPORTER CHAPERONE 4; 1.
DR   Pfam; PF02656; DUF202; 1.
DR   Pfam; PF09359; VTC; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000009138};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        461..482
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        488..506
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        526..546
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          83..318
FT                   /note="VTC"
FT                   /evidence="ECO:0000259|Pfam:PF09359"
FT   DOMAIN          454..512
FT                   /note="DUF202"
FT                   /evidence="ECO:0000259|Pfam:PF02656"
FT   REGION          595..615
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   615 AA;  72098 MW;  E75B1D26341C0C8D CRC64;
     MYFTRHKIDS EFERISQFIE TKMKQPKGLH EARLLLDFIH LNTFGFKKIL KKHDKWTEFT
     LEHRFAGWDR HIAELHQILC LKYHETSYWI HPDNLKELES ILLFHLPKEE VQNVQSVYFD
     SLNDFQLYSD VLKKKKGAEL IRMTTWHKAE NPLSIVLFEQ KEFEEFETIS ATNKSFYLKP
     HLADKYLRGE WTPNDILDDL QLYLDQNSLK TTVSVASTIS KSIQQTQPIL RCHYQSTLYS
     ANPNHILTLK TNLSFSKEIN RHPTSQGDQH LFPYAILKLK SAKNEQIPDW LSHLTDHSRL
     IYKVPYFEEY LHGMSCFFQD RLPLLPWWLN ELNKDIRKGS LASLYLDEKE QQDYLDDDIK
     ENLLSSSLTV TDQEPRRISK QGYLFTSNIV TRIKNMKSFG EDAPPPVYGP DDMNIFKWLY
     AKFTNDKEFL SPVLPNQDPR IMSKKTARLE PKLFMANERI FMSWLQFCAL LLTLSLGLIN
     FGDQTSRISG ALFIMISITV SAYSLLRYQY RAWQIRFRSN IRFDDIYGPA GLCFIFVLAA
     VINLGLRMDH PVEGLVNPFG KTLNETRFNL TEHNTTFTPL SSVDDKALNK HVSKHNTTKV
     NKYGKTKEDE DEDED
//