ID I1BLE9_RHIO9 Unreviewed; 1526 AA.
AC I1BLE9;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Reverse transcriptase {ECO:0008006|Google:ProtNLM};
GN ORFNames=RO3G_01733 {ECO:0000313|EMBL:EIE77029.1};
OS Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE77029.1, ECO:0000313|Proteomes:UP000009138};
RN [1] {ECO:0000313|EMBL:EIE77029.1, ECO:0000313|Proteomes:UP000009138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC {ECO:0000313|Proteomes:UP000009138};
RX PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT whole-genome duplication.";
RL PLoS Genet. 5:E1000549-E1000549(2009).
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DR EMBL; CH476732; EIE77029.1; -; Genomic_DNA.
DR STRING; 246409.I1BLE9; -.
DR VEuPathDB; FungiDB:RO3G_01733; -.
DR eggNOG; KOG0017; Eukaryota.
DR InParanoid; I1BLE9; -.
DR OrthoDB; 1367639at2759; -.
DR Proteomes; UP000009138; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR CDD; cd00024; CD_CSD; 1.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041577; RT_RNaseH_2.
DR PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR Pfam; PF00385; Chromo; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF17919; RT_RNaseH_2; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SMART; SM00298; CHROMO; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50013; CHROMO_2; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009138};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Transposable element {ECO:0000256|ARBA:ARBA00022464}.
FT DOMAIN 652..835
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 1160..1318
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT DOMAIN 1447..1505
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT REGION 336..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 562..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1499..1526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1526 AA; 172993 MW; 66EEB5D5DBE1E283 CRC64;
MAAQNNLPME INTINNAQDV SPLVPADIRS TSSQEATEPV LPYQNDADMM ETADDIPLVT
GNTDALSILR QQLQEVSQRF ARGVSNHLPM DQLESLRNEA SHIASCIKYL LEVQTYCEPP
KVETTQQSVN QSSNRFDHFI PNDLPTWQWV GNVWRMDVEV HDSVEDLLDT FALIVSSNGL
AIDQHWMRLV PIKMNRDQRS WFNEVLKGRS LNWDEARSII VNTYATQDVA QTLNNIDQLL
TIKMQQNESI EAFTDRFQRI RRAAKWQDDI RTAALFKRAL PVALYKEVSR SLLNLPLNQQ
DSVCKVSAKA RTVISSNICN DEAMAAGVTK RNITTQSSSN PISFVSGAEK SMHNPKNASG
PSKQGQPQFK PKSRCLVHGN GNHTTEQCKV LKRIATANTA TTATTATNVT PQASNTKKNC
YKCSANVPWS PDHAATCSKD KVKRFNGPTK AFRSARFSGS HNRTCLQTMT ILHSLIKITF
NINNNVSGSI VFATNDNKSK RFGTTSKALS LIYGDNDDTL IHTSPIFEVL PLSFDTDAVI
GLDLMPKLNI LITNLAVKHP NKKPAAKEEI DDTPEPNNSP YGTTDQQINF MAAVKSDLDQ
NAQIPKNSFC TVPESIIHLD TEKNKTAYRS PYRIPLKLMP VMRECVDTWL KDEVIEYAPP
SSEWNSPLTL APKKDLQGNL TGYRPCLDPR LLNSILISND KQPIPKIDEI FDQLQGSTIF
TTLDLRQAFH RFQIYKPDRV KTTFTFQGQQ YMFKGCPFGL KHIASRYQRV INSILADVPH
ALAFVDDIII FSKSYEEHIT HVQNVIKKLT NVNLILNVDK CHFAQTSVYL LGFCVDAKGS
RLDPRKVTNA LSWEKPSTGK DIQRFLGLVN YFRKYLPNLS EVTAPLDKLR FEGKLTSKVW
GQEQDDAFTK IKQLLASAPV LYHPDLSEPF YVATDASNYS IGAVLYQIID KQIRHLGFMA
RALSTSEKNY STTKRELLAI VFALKKFHPF LWGNPFTLYT DHKALTYIHT QPVANSMMIQ
WLDTILDYDF KIIHRPGIQN VLPDMLSRLF ESERTLVGDK NQHKTWITPQ VANSKNTNMT
TRMMMPDDLV TPAPEERQEL LLKTHLEGHR GSQAMVTTLH SEGIHWTNLK QDALDCINSC
PDCQKFNVAK HGYHPLSSIY ADAPWDHICI DTAGPMTTSI QGNNYILVVV DVFTRFCVLK
AMPDKSSHTI ALALRSILPL FGRPKIIQSD NGTEYVNDII RKYTEVSGID HRLITAYHPR
SNGIAERWVG KTKNIIYKRL QGKNDDWDLY LDSTQEALNN TPTALHDTRP FSLMFARRPN
QFKDYSDVSI PTNYNETRKQ FNGHITKFNN TVLPAIREKI KTSQTAAENK FNKSHRIIKE
IPSGSQVTIK NINRTAKTDP LYIGNYTIVR KNQGGSYILV DGTGALLPRN IPPSHIKVIS
EEQSEVYDVE AVIDHKGTPG NWLYLVRWKG YDAKDDTWEP EKHFHDNRPI LKYWNRRNGQ
HNVEPNSSEK RPRKNHDNSS RKRARN
//
