ID I1BMV1_RHIO9 Unreviewed; 1415 AA.
AC I1BMV1;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Reverse transcriptase {ECO:0008006|Google:ProtNLM};
GN ORFNames=RO3G_02235 {ECO:0000313|EMBL:EIE77531.1};
OS Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE77531.1, ECO:0000313|Proteomes:UP000009138};
RN [1] {ECO:0000313|EMBL:EIE77531.1, ECO:0000313|Proteomes:UP000009138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC {ECO:0000313|Proteomes:UP000009138};
RX PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT whole-genome duplication.";
RL PLoS Genet. 5:E1000549-E1000549(2009).
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DR EMBL; CH476733; EIE77531.1; -; Genomic_DNA.
DR STRING; 246409.I1BMV1; -.
DR VEuPathDB; FungiDB:RO3G_02235; -.
DR eggNOG; KOG0017; Eukaryota.
DR InParanoid; I1BMV1; -.
DR OMA; DARTHVQ; -.
DR OrthoDB; 1367639at2759; -.
DR Proteomes; UP000009138; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0015074; P:DNA integration; IEA:InterPro.
DR CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR CDD; cd01647; RT_LTR; 1.
DR Gene3D; 1.10.340.70; -; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR Gene3D; 3.30.70.270; -; 2.
DR Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR001584; Integrase_cat-core.
DR InterPro; IPR041588; Integrase_H2C2.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR041577; RT_RNaseH_2.
DR PANTHER; PTHR37984:SF7; INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR37984; PROTEIN CBG26694; 1.
DR Pfam; PF00385; Chromo; 1.
DR Pfam; PF17921; Integrase_H2C2; 1.
DR Pfam; PF17919; RT_RNaseH_2; 1.
DR Pfam; PF00665; rve; 1.
DR Pfam; PF00078; RVT_1; 1.
DR SMART; SM00298; CHROMO; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50013; CHROMO_2; 1.
DR PROSITE; PS50994; INTEGRASE; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000009138};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Transposable element {ECO:0000256|ARBA:ARBA00022464}.
FT DOMAIN 494..680
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT DOMAIN 1034..1192
FT /note="Integrase catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50994"
FT DOMAIN 1331..1390
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT REGION 118..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 170..309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1385..1415
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1415 AA; 158530 MW; C0B1C0FFDEC6AB17 CRC64;
MYIQQFKKAF TGHYGVGSAE EKATSTTELL RISMTAAETV DQYVERFNNL RRLAQIQDRC
VLTRCFLIGL QADIYKKVIV SLANCTDAQK ESVDYVVKLA KTLYHSLYKV RRVANASHTS
AGPSMVNDSS SSGRKKSSAF ISGSAVRAAP YPKASRKYCS FHKTTTHSND ECRAMKKSSS
LSPSSGSTQV DVSSGSAASQ WNPRNQPSGL GRPCRSCGAD NWRPGHRCKG KGRSTGSSAD
DSDLAGPSHL FRGMSRSPAS SLSSVASSGN DVSASVGSSA TPTTSSSDAS SGRKTDAAGP
VVSVPDSSDD MDIDVAETLT VAEAAQAFPT PNPGSIKLGH NSSSTVSRLG IINLTVYYNQ
IRLSYEFEVF DFSSDVPICL GLDILPKLRI GLTGLATSWL NSNIPKIPDP VNPDDYKPNE
TPVGTKQERQ QLMSTIQPLL DANTSIPMSS HCNLPGAIIT LDTEPNAFAY RRQPDIAIAN
RKIMEDQIQT WLDDCVIEPA PSNTRFNNPI FLVGKKDVNG LYTKKRAVID PRMLNQLVKN
VDRMPLPLIS DLHQRMGSAT IFTTFDIRAC FHRFLIQESD RPKTAFTHPF TGMQYQFRHC
PFGLTSTGNI VQRVLTNLFA DLPYTALYID DLCVFSSGDM NQHIEYVREV LKRLTAANLI
INVEKTHFAQ SCVNILGWTI GNNGSLIPDQ RKLTNIHSWP TPKTGRQVMS FLGFANYFRN
SLPMFSRLTA PLDRLRSLNS LKGIWNETHE CSFRNIKDAL VNAPVIPIPN LKYPFYVATD
ASAYGIGGVV YQVIDQVIQY NAFAARSLSP TERRYHTNKR ELLAIVFMFE RYNKWLYNRH
FTLTTDHKAL IYIKKQVVPN AAMLVWFETI FEYSFDIVHC PGIKNIIPDA LSRLFPDDNK
LEGGNNVNNV AIYSIRGKEK EKRKPTFKEK SKSYETQTYA VTSATSSSSS KPLLHRALQY
EDYITPPPEE RKDIILKAHL LGHYGIKAIE QTIHGDKLHW TNLRQDIQDV ISKCHECKMF
NIAKTGYHPP RSILPDGPLD HWVMDLGTFN ITSTSGNNFL LVMVDLFSRF TILKAIPDKQ
ALTIAKQLVD IFCTFGWPKV IASDNGKEFT ATIVTELINN SGIDKRVSNP FNPLGNSVNE
AFVGIAKKTI VKQLQGRKEN WDLYVPATQY AMNLKYSRLH KSRPYTVIFN KVPNDMKDYS
HIKPTLRSEA VDSKAIENRL KYATEVVIPA LAKRIKETQD VDNAYFMKTN KIVHTPFPLH
SEVMIKNVNK ENKTDPYYEG PFYISGMTTN GSYILVDKQN NLLSRDVPTS HLKLIALPSN
KSAESIDDQH YEIQAVIQHK GTPGNYQYLV HWKGYDDPMD YTWEPTSSFD DRSSIETYWA
RRQAGNNTAV SKKARLPKCT VPTRDHHSRS KRSRR
//
