ID I1BUG7_RHIO9 Unreviewed; 546 AA.
AC I1BUG7;
DT 13-JUN-2012, integrated into UniProtKB/TrEMBL.
DT 13-JUN-2012, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0000259|PROSITE:PS50009};
GN ORFNames=RO3G_04552 {ECO:0000313|EMBL:EIE79847.1};
OS Rhizopus delemar (strain RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL
OS 43880) (Mucormycosis agent) (Rhizopus arrhizus var. delemar).
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Mucoromycotina;
OC Mucoromycetes; Mucorales; Mucorineae; Rhizopodaceae; Rhizopus.
OX NCBI_TaxID=246409 {ECO:0000313|EMBL:EIE79847.1, ECO:0000313|Proteomes:UP000009138};
RN [1] {ECO:0000313|EMBL:EIE79847.1, ECO:0000313|Proteomes:UP000009138}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RA 99-880 / ATCC MYA-4621 / FGSC 9543 / NRRL 43880
RC {ECO:0000313|Proteomes:UP000009138};
RX PubMed=19578406; DOI=10.1371/journal.pgen.1000549;
RA Ma L.-J., Ibrahim A.S., Skory C., Grabherr M.G., Burger G., Butler M.,
RA Elias M., Idnurm A., Lang B.F., Sone T., Abe A., Calvo S.E.,
RA Corrochano L.M., Engels R., Fu J., Hansberg W., Kim J.-M., Kodira C.D.,
RA Koehrsen M.J., Liu B., Miranda-Saavedra D., O'Leary S.,
RA Ortiz-Castellanos L., Poulter R., Rodriguez-Romero J., Ruiz-Herrera J.,
RA Shen Y.-Q., Zeng Q., Galagan J., Birren B.W., Cuomo C.A., Wickes B.L.;
RT "Genomic analysis of the basal lineage fungus Rhizopus oryzae reveals a
RT whole-genome duplication.";
RL PLoS Genet. 5:E1000549-E1000549(2009).
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DR EMBL; CH476734; EIE79847.1; -; Genomic_DNA.
DR AlphaFoldDB; I1BUG7; -.
DR STRING; 246409.I1BUG7; -.
DR VEuPathDB; FungiDB:RO3G_04552; -.
DR eggNOG; KOG3629; Eukaryota.
DR InParanoid; I1BUG7; -.
DR OMA; GEINACH; -.
DR OrthoDB; 1387014at2759; -.
DR Proteomes; UP000009138; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000009138}.
FT DOMAIN 242..482
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 77..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..108
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 546 AA; 61093 MW; 66613E3BC92090D8 CRC64;
MEDPLSSLNT ASHHFDNGQI KDAYYLFLNT AQNAIQPFFD VKFVHCSIVS KPQKYDTLLC
ILRTCLDEIE KIVENHSIST NKAPPPLPPK PSTSSKPVLP PKPTRPLPVA PAIKQDSEVA
LPRVPNGEID PSHLVPAQTN NNDTLTPSAN SKNIPHIPAP PLLTTHRVLQ TKLDSLESLL
NDYRTQKRLV QQGTDNGQMT ESELNDAIAR YTPCVAEAKH TLNKIRTVYM TAATIPSILH
FQPGIIAYQI TRIESAIFSV IPAQALLTHS PKNPHPRIIA STDFFNFITR LIEHSILLPQ
EASSRAQHIH HWIKIATKCQ DLNNYQTLKA IVSALGTPPV QRLKRTWAYI PKKSMVKLEA
LNELMSESNN YGKYREHMGI ASTSVLNGKS VTKIQSDHCK RPTVPFLGTF IHDMTYLLAA
VQQQQGTSSD ALQKDARVQK LLKTLSLFQS CPPYDKKPNA MYAKALQKNP IRPAFTQAIH
RSKSSFGRLG GAIGFGGNNE SEAWGCAKQQ CRKSICKFTD KQQYKFVHEN ECKWTQHNNK
CFPKHA
//
